Diversity of Cl- channels

Cellular and Molecular Life Sciences

Volumn 63, Issue 1, 2006, Pages 12-24

  Suzuki, M ^a   Morita, T ^a   Iwamoto, T ^b  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Bestrophin; Ca2+ activation; CFTR; ClC; Knockout mouse; Pharmacology; Tweety; Volume regulation

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; ALKANOIC ACID; AMINOBENZOIC ACID DERIVATIVE; ANTHRACENE DERIVATIVE; CHLORIDE CHANNEL; FENAMIC ACID DERIVATIVE; FLUOXETINE; GLIBENCLAMIDE; MACROLIDE; MEFLOQUINE; MEMBRANE PROTEIN; SCORPION VENOM; STILBENEDISULFONIC ACID; SULFONYLUREA; SURAMIN; TAMOXIFEN; TOLBUTAMIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

CELL GROWTH; CELL MEMBRANE POTENTIAL; CELL VOLUME; CHANNEL GATING; ENDOSOME; EXCITABLE MEMBRANE; FLUID TRANSPORT; HUMAN; MEMBRANE CHANNEL; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; BODY FLUIDS; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; CHLORIDE CHANNELS; HUMANS; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT MODULATORS;

SCORPIONES;

EID: 30844450119     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-005-5336-4     Document Type: Review

References (133)

1. Jentsch T. J., Steinmeyer K. and Schwarz G. (1990) Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature 348: 510-514
2. Jentsch T. J., Stein V., Weinreich F. and Zdebik A. A. (2002) Molecular structure and physiological function of chloride channels. Physiol. Rev. 82: 503-568
3. Nilius B. (2001) Chloride channels go cell cycling. J. Physiol. 532: 581
4. Nilius B. and Droogmans G. (2003) Amazing chloride channels: an overview. Acta Physiol. Scand. 177: 119-147
5. Nilius B. and Droogmans G. (2002) Calcium activated chloride channels in vascular endothelial cells. In: Ca2+-activated Cl channels, pp. 327-344, Fuller K. (ed.), Academic Press, New York
6. Nilius B., Eggermont J., Voets T. and Droogmans G. (1996) Volume-activated Cl channels. Gen. Pharmacol. 27: 1131-1140
7. Fahlke C., Rhodes T. H., Desai R. R. and George A. L. Jr. (1998) Pore stoichiometry of a voltage-gated chloride channel. Nature 394: 687-690
8. Lin C. W. and Chen T. Y. (2000) Cysteine modification of a putative pore residue in ClC-0: implication for the pore stoichiometry of ClC chloride channels. J. Gen. Physiol. 116: 535-546
9. Chen T. Y. (2005) Structure and function of ClC channels. Annu. Rev. Physiol. 67: 809-839
10. Schwiebert E. M., Egan M. E., Hwang T. H., Fulmer S. B., Alien S. S., Cutting G. R. et al. (1995) CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 81: 1063-1073
11. Jentsch T. J. (2002) Chloride channels are different. Nature 415: 276-277
12. Gandhi R., Elble R. C., Gruber A. D., Schreur K. D., Ji H. L., Fuller C. M. et al. (1998) Molecular and functional characterization of a calcium-sensitive chloride channel from mouse lung. J. Biol. Chem. 273: 32096-32101
13. 2+-activated Cl channel proteins. Genomics 54: 200-214
14. Sun H., Tsunenari T., Yau K. W. and Nathans J. (2000) The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc. Natl. Acad. Sci. USA 99: 4008-4013
15. Suzuki M. and Mizuno A. (2004) A novel Cl channel related to Drosophila flightless locus. J. Biol. Chem 279: 22461-22468
16. - channels. Nature 365: 850-852
17. Wadiche J. I. and Kavanaugh M. P. (1998) Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J. Neurosci. 18: 7650-7661
18. Yasui M., Hazama A., Kwon T. H., Nielsen S., Guggino W. B. and Agre P. (1999) Rapid gating and anion permeability of an intracellular aquaporin. Nature 402: 184-187
19. Dutzler R., Campbell E. B., Cadene M., Chait B. T. and MacKinnon R. (2002) X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415: 287-294
20. - channels. Nature 427, 803-807
21. Grove A., Iwamoto T., Montal M. S., Tomich J. M. and Montal M. (1992) Synthetic peptides and proteins as models for pore-forming structure of channel proteins. Methods Enzymol. 207: 510-525
22. Montal M. O., Iwamoto T., Tomich J. M. and Montal M. (1993) Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor. FEBS Lett. 320: 261-266
23. Montal O. M., Buhler L. K., Iwamoto T., Tomich J. M. and Montal M. (1993) Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. I. Transmembrane segment M2 of the nicotinic cholinergic receptor channel is a key pore-lining structure. J. Biol. Chem. 268: 14601-14607
24. A. In: Ion Channel Factsbook vol. 1, pp. 293-365, Conley E. and Brammer W. (eds.), Academic Press, London
25. Farrant M. and Cull-Candy S. (1993) GABA receptors, granule cells and genes. Nature 361: 302-303
26. Conley E. (1996) Cl glycine. In: Ion Channel Factsbook, vol. 1, pp. 367-399, Academic Press, London
27. Pusch M., Ludewig U., Rehfeldt A. and Jentsch T. J. (1995) Gating of the voltage-dependent chloride channel ClC-0 by the permeant anion. Nature 373: 527-531
28. Jentsch T. J. and Gunther W.(1997) Chloride channels: an emerging molecular picture. Bioessays 119:117-126
29. Rychkov G. Y., Pusch M., Astill D. S., Roberts M. L., Jentsch T. J. and Bretag A. H. (1996) Concentration and pH dependence of skeletal muscle chloride channel ClC-1. J. Physiol. 497: 423-435
30. Kubisch C., Schmidt-Rose T., Fontaine B., Bretag A. H. and Jentsch T. J. (1998) ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence. Hum. Mol. Genet. 7: 1753-1760
31. Thiemann A., Grunder S., Pusch M. and Jentsch T. J. (1992) A chloride channel widely expressed in epithelial and non-epithelial cells. Nature. 356: 57-60
32. Grunder S., Thiemann A., Pusch M. and Jentsch T. J. (1992) Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume. Nature 360: 759-762
33. Stanley K. The role of an inwardly rectifying chloride conductance in postsynaptic inhibition. (1994) J. Neurophysiol. 72: 273-284
34. - concentration in the intralobular duct cells of mouse mandibular glands. J. Membr. Biol. 135: 289-295
35. Smith R. L., Clayton G. H., Wilcox C. L., Escudero K. W. and Staley K. J. (1995) Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition. J. Neurosci. 15: 4057-4067
36. A receptor function following gene transfer of the CLC-2 chloride channel. Neuron 17: 543-551
37. Bösl M. R., Stein V., Hübner C., Zdebik A. A., Jordt S. E., Mukhophadhyay A. K. et al. (2001) Male germ cells and photoreceptors, both depending on close cell-cell interactions, degenerate upon ClC-2 Cl-channel disruption. EMBO J. 20: 1289-1299
38. Conley E. C. and Brammar W. J. (1996) CaCC. In: The Ion Channel Facts Book, vol. 2, pp. 524-571. Academic Press, London
39. - current in rat vascular smooth muscle cells in short-term primary culture. Pflugers Arch. 419: 553-558
40. Saleh S. N. and Greenwood I. A. (2005) Activation of chloride currents in murine portal vein smooth muscle cells by membrane depolarization involves intracellular calcium release. Am. J. Physiol. Cell. Physiol. 288: C122-131
41. Brenner R., Perez G. J., Bonev A. D., Eckman D. M., Kosek J. C., Wiler S. W. et al. (2000) Vasoregulation by the b subunit of the calcium-activated potassium channel. Nature 407: 870-876
42. Evans S. R., Thoreson W. B. and Beck C. L. (2004) Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine. J. Biol. Chem. 279: 41792-41800
43. Ritzka M., Stanke F., Jansen S., Gruber A. D,. Pusch L., Woelfl S. et al. (2004) The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. Hum. Genet. 115: 483-491
44. Britton F. C., Ohya S., Horowitz B. and Greenwood I. A. (2002) Comparison of the properties of CLCA1 generated currents and I[Cl(Ca)] in murine portal vein smooth muscle cells. J Physiol. 539: 107-117
45. 2+ activated chloride channel CLCA2. Cancer Res. 59: 5488-5491
46. Pauli B. U., Abdel-Ghany M., Cheng H. C., Gruber A. D., Archibald H. A. and Elble, R. C. (2000) Molecular characteristics and functional diversity of CLCA family members. Clin. Exp. Pharmacol. Physiol. 27: 901-905
47. Ghany A., Cheng H. C., Elble R. C. and Pauli B. U. (2001) The breast cancer beta(4) integrin and endothelial human CLCA2 mediate lung metastasis. J. Biol. Chem. 276: 25438-25446
48. Petrukhin K., Koisti M. J., Bakall B., Li W., Xie G., Marknell T. et al. (1998) Identification of the gene responsible for Best macular dystrophy. Nat. Genet. 19: 241-224
49. Marquardt A., Stohr H., Passmore L. A., Kramer F., Rivera A. and Weber B. H. (1998) Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease). Hum. Mol. Genet. 7: 1517-1525
50. Gallemore R. P., Hughes B. A. and Miller S. S. (1998) Light-induced responses of the retinal pigment epithelium. In: The Retinal Pigment Epithelium, Marmor M. F. and Wolfensberger T. J. (eds.), pp. 175-198, Oxford University Press, New York
51. Marmorstein L. Y., McLaughlin P. J., Brett Stanton J. B., Yan L., Crabb J. W. and Marmorstein A. D. (2002) Bestrophin interacts physically and functionally with protein phosphatase 2A. J. Biol. Chem. 277: 30591-30597
52. Fischmeister R. and Hartzell H. C. (2005) Volume-sensitivity of the bestrophin family of chloride channels. J. Physiol. 562: 477-491
53. Nilius B., Voets T., Eggermont J. and Droogmans G. (1999) VRAC: a multifunctional volume regulated anion channel in vascular endothelium. In: Chloride Channels, Kozlowski R. (ed.), pp. 47-63. Isis Medical Media Limited, Oxford
54. Okada Y. (1997) Volume expansion-sensing outward-rectifier Cl channel: fresh start to the molecular identity and volume sensor. Am. J. Physiol. 273: C755-C789
55. Clapham D. E. (1998) The list of potential volume-sensitive chloride currents continues to swell (and shrink). J. Physiol. Lond. 111: 623-624
56. 2+/calmodulin- dependent protein kinase. J. Biol. Chem. 276: 20093-20100
57. Lepple-Wienhues A., Szabo I., Laun T., Kaba N. K., Gulbins E. and Lang F. (1998) The tyrosine kinase p56(lck) mediates activation of swelling-induced chloride channels in lymphocytes. J. Cell. Biol. 141: 281-286
58. Nilius B., Voets T., Prenen J. Barth H., Aktories K., Kaibuchi K. et al.(1999) Role of RhoA and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. J. Physiol. 516: 67-74
59. Valverde M. A., Diaz M., Sepulveda F. V., Gill D. R., Hyde S. C. and Higgins C. F. (1992) Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Nature 355: 830-833
60. Paulmichl M., Li Y., Wickman K., Ackerman M., Peralta E. and Clapham D. (1992) New mammalian chloride channel identified by expression cloning. Nature 356: 238-241
61. Valverde M. A., Diaz M., Sepulveda F. V., Gill D. R., Hyde S. C. and Higgins C. F. (1992) Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Nature 355: 830-833
62. Valverde M. A., Bond T. D., Hardy S. P. Taylor J. C., Higgins C. F., Altamirano J. et al. (1996) The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease. EMBO J. 15: 4460-4468
63. Krapivinsky G., Pu W., Wickman K., Krapivinsky L. and Clapham D. E. (1998) pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J. Biol. Chem. 273: 10811-10814
64. Pu W. T., Wickman K. and Clapham D. E. (2000) ICln is essential for cellular and early embryonic viability. J. Biol. Chem. 275: 12363-12366
65. Kawasaki M., Fukuma T., Yamauchi K., Sakamoto H., Marumo F. and Sasaki S. (1999) Identification of an acid-activated Cl channel from human skeletal muscles. Am. J. Physiol. Cell. Physiol. 277: C948-C954
66. Li X., Shimada K., Showalter L. A. and Weinman S. A. (2000) Biophysical properties of ClC-3 differentiate it from swelling-activated chloride channels in Chinese hamster ovary-K1 cells. J. Biol. Chem. 275: 35994-35998
67. Weylandt K. H., Valverde M. A., Nobles M., Raguz S., Amey J. S., Diaz M. et al. (2001) Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation. J. Biol. Chem. 276: 17461-17467
68. Stobrawa S. M., Breiderhoff T., Takamori S., Engel D., Schweizer M., Zdebik A. A. et al. (2001) Disruption of CIC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron 29: 185-196
69. Vessey J. P., Shi C., Jollimore C. A., Stevens K. T., Coca-Prados M., Barnes S. et al. (2004) Hyposmotic activation of ICl, swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. Biochem. Cell Biol. 82: 708-718
70. - concentration through volume-regulated ClC-3 chloride channels in A10 vascular smooth muscle cells. J. Biol. Chem. 280: 7301-7308
71. Salazar G., Love R., Styers M. L., Werner E., Peden A., Rodriguez S. et al. (2004) AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells. J. Biol. Chem. 279: 25430-25439
72. Hermoso M., Satterwhite C. M. andrade Y., Hidalgo J., Wilson S. M., Horowitz B. et al. (2002) ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl channel and volume regulation in HeLa cells and Xenopus laevis oocytes. J. Biol. Chem. 205: 132-200
73. Mitchell C. H., Wang L. and Jacob T. J. C. (1997) A large-conductance chloride channel in pigmented ciliary epithelial cells activated by GTP gamma S. J. Membr. Biol. 158: 167-175
74. Diaz M., Bahamonde M. I., Lock H., Munoz F. J., Hardy S. P., Posas F. et al. (2001) Okadaic acid-sensitive activation of Maxi Cl channels by triphenylethylene antioestrogens in C1300 mouse neuroblastoma cells. J. Physiol. 536: 79-88
75. Kokubun S., Saigusa A. and Tamura T. (1991) Blockade of Cl channels by organic and inorganic blockers in vascular smooth muscle cells. Pflugers Arch. 418: 204-213
76. Sabirov R. Z., Dutta A. K. and Okada Y. (2001) Volume-dependent ATP-conductive large-conductance anion channel as a pathway for swelling-induced ATP release. J. Gen. Physiol. 118: 251-266
77. Bell P. D., Lapointe J. Y., Sabirov R., Hayashi S., Peti-Peterdi J. Manabe K. et al. (2003) Macula densa cell signaling involves ATP release through a maxi anion channel. Proc. Natl. Acad. Sci. USA 100: 4322-4327
78. Bell P. D., Lapointe J. Y. and Peti-Peterdi J. (2003) Macula densa cell signaling. Annu. Rev. Physiol. 65: 481-500
79. Campbell H. D., Kamei M., Claudianos C., Woollatt E., Sutherland G. R., Suzuki Y. et al. (2000) Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: a novel gene family encoding predicted transmembrane proteins. Genomics 68: 89-92
80. Nagasawa M., Kanzaki M., Iino Y., Morishita Y. and Kojima I. (2001) Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus. J. Biol. Chem. 276: 20413-20418
81. Kanzaki M., Nagasawa M., Kojima I., Sato C., Naruse K., Sokabe M. et al. (1999) Molecular identification of a eukaryotic, stretch-activated nonselective cation channel. Science 285: 882-886
82. Uchida S. and Sasaki S. (2005) Function of chloride channels in the kidney. Annu. Rev. Physiol. 67: 759-778
83. Jentsch T. J. (2005) Chloride transport in the kidney: lessons from human disease and knockout mice. J. Am. Soc. Nephrol. 16: 1549-1561
84. + secretion. Nature 414: 558-561
85. Rommens J. M., Iannuzzi M. C., Kerem B., Drumm M. L., Melmer G., Dean M. et al. (1989) Identification of the cystic fibrosis gene:chromosome walking and jumping. Science 245: 1059-1065
86. Riordan J. R., Rommens J. M., Kerem B., Alon N., Rozmahel R., Grzelczak Z. et al. (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1072
87. Berger H. A., Anderson M. P., Gregoryt R. J., Thompson S., Howard P. W., Maurer R. A. et al. (1991) Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel. J. Clin. Invest. 88: 1422-1431
88. Hallows K. R., Raghuram V., Kemp B. E., Schwiebert E. M., Morales M. M., Lopes A. G. et al. (1998) Chloride channel and chloride conductance regulator domains of CFTR, the cystic fibrosis transmembrane conductance regulator. Proc. Natl. Acad. Sci. USA 95: 2674-2679
89. Schwiebert E. M., Benos D. J., Egan M. E., Stutts M. J. and Guggino W. B. (1999) CFTR is a conductance regulator as well as a chloride channel. Physiol. Rev. 79: S145-S166
90. Piwon N., Gunther W., Schwake M., Bosl M. R. and Jentsch T. J. (2000) ClC-5 Cl-channel disruption impairs endocytosis in a mouse model for Dent's disease. Nature 408: 369-373
91. Lloyd S. E., Pearce S. H., Fisher S. E., Steinmeyer K., Schwappach B., Scheinman S. J. et al. (1996) A common molecular basis for three inherited kidney stone diseases. Nature 379: 445-449
92. GuÈnther W., LuÈchow A., Cluzeaud F., Vandewalle A. and Jentsch T. J. (1998) ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells. Proc. Natl Acad. Sci. USA 95: 8075-8080
93. Nykjaer A., Dragun D., Walther D., Vorum H., Jacobsen C., Herz J. et al. (1999) An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 96: 507-515
94. Christensen E. I., Devuyst O., Dom G., Nielsen R., Van der Smissen P., Verroust P. et al. (2003) Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proc. Natl. Acad. Sci. USA. 100: 8472-8477
95. Yoshikawa M., Uchida S., Ezaki J., Rai T., Hayama A., Kobayashi K. et al. (2002) CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells 7: 597-605
96. Kasper D., Planells-Cases R., Fuhrmann J. C., Scheel O., Zeitz O., Ruether K. et al. (2005) Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration. EMBO J. 24: 1079-1091
97. Yasui M., Kwon T. H., Knepper M. A., Nielsen S. and Agre P. (1999) Aquaporin-6: an intracellular vesicle water channel protein in renal epithelia. Proc. Natl. Acad. Sci. USA. 96: 5808-5813
98. Jiang B., Hattori N., Liu B., Nakayama Y., Kitagawa K. and Inagaki C. (2004) Suppression of cell proliferation with induction of p21 by Cl(-) channel blockers in human leukemic cells. Eur J Pharmacol. 488: 27-34
99. Shimizu T., Numata T. and Okada Y. (2004) A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel. Proc. Natl. Acad. Sci. USA. 101: 6770-6773
100. Loewen M. E., Bekar L. K., Walz W., Forsyth G. W. and Gabriel S. E. (2004) pCLCA1 lacks inherent chloride channel activity in an epithelial colon carcinoma cell line. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G33-G41
101. Gogelein H., Dahlem D., Englert H. C. and Lang H. J. (1990) Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas. FEBS Lett. 268: 79-82
102. Ma T., Thiagarajah J. R., Yang H., Sonawane N. D., Folli C., Galietta L. J. V. et al. (2002) Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion J. Clin. Invest. 110: 1651-1658
103. Fuller M. D., Zhang Z. R., Cui G., Kubanek J. and McCarty N. A. (2004) Inhibition of CFTR channels by a peptide toxin of scorpion venom. Am. J. Physiol. Cell. Physiol. 287: C1328-C1341
104. Maertens C., Wei L., Tytgat J., Droogmans G. and Nilius B. (2000) Chlorotoxin does not inhibit volume-regulated, calcium-activated and cyclic AMP-activated chloride channels. Br. J. Pharmacol. 129: 791-801
105. Pedemonte N., Sonawane N. D., Taddei A., Hu J., Zegarra-Moran O,. Suen Y. F. et al. (2005) Phenylglycine and sulfonamide correctors of defective DF508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol. Pharmacol. 67: 1797-1807
106. Maertens C., Wei L., Droogmans G. and Nilius B. (2000) Inhibition of volume-regulated and calcium-activated chloride channels by the antimalarial mefloquine. J. Pharmacol. Exp. Ther. 295: 29-36
107. Nakaya Y., Kuzu N., Nakamura Y. and Sone S. (1998) Suppressive action of erythromycin on cultured tracheal epithelial cell chloride channel activated by interferon-gamma. Jpn. J. Antibiot. 51: 152-154
108. Corry B., O'Mara M. and Chung S. H. (2004) Conduction mechanisms of chloride ions in ClC-type channels. Biophys. J. 86: 846-60
109. Estevez R., Pusch M., Ferrer-Costa C., Orozco M. and Jentsch T. J. (2004) Functional and structural conservation of CBS domains from CLC chloride channels. J. Physiol. 557: 363-378
110. Chen T. Y. (2005) Structure and function of ClC channels. Annu. Rev. Physiol. 67: 809-839
111. Babini E. and Pusch M. (2004) A two-holed story: structural secrets about ClC proteins become unraveled? Physiology. 19: 293-299
112. Estevez R., Pusch M., Ferrer-Costa C., Orozco M. and Jentsch T. J. (2004) Functional and structural conservation of CBS domains from CLC chloride channels. J. Physiol. 557: 363-378
113. Scheel O., Zdebik A. A., Lourdel S. and Jentsch T. J. (2005) Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 436: 424-427
114. Riordan J. R. (2005) Assembly of functional CFTR chloride channels. Annu. Rev. Physiol. 67: 701-718
115. Montal O. M., Reddy G. L., Iwamoto T., Tomich J. M. and Montal M. (1994) Identification of an ion channel-forming motif in the primary structure of CFTR, the cystic fibrosis chloride channel. Proc. Natl. Acad. Sci. USA. 91: 1495-1499
116. Broughman J. R., Shank L. P., Takeguchi W., Schultz B. D., Iwamoto T., Mitchell K. E. et al. (2002) Distinct structural elements that direct solution aggregation and membrane assembly in the channel-forming peptide M2GlyR. Biochemistry 41: 7350-7358
117. Gao L., Broughman J. R., Iwamoto T., Tomich J. M., Venglarik C. J. and Forman H. J. (2001) Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L24-L30
118. Bormann J., Hamill O. P. and Sakmann B. (1987) Mechanism of anion permeation through channels gated by glycine and gamma-aminobutyric acid in mouse cultured spinal neurones. J. Physiol. 385: 243-286
119. Berger H. A., Anderson M. P., Gregory R. J., Thompson S., Howard P. W. Maurer R. A. et al. (1991) Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel. J. Clin. Invest. 88: 1422-1431
120. Edwards J. C., Tulk B. and Schlesinger P. H. (1998) Functional expression of p64, an intracellular chloride channel protein. J. Membr. Biol. 163: 119-127
121. Li X., Shimada, K., Lori A., Showalter L. A. and Weinman S. A. (2000) Biophysical properties of ClC-3 differentiate it from swelling activated chloride channels in Chinese hamster ovary-K1 cells. J. Biol. Chem. 275: 35994-35998
122. Zhu G., Zhang Y., Xu H. and Jiang C., (1998) Identification of endogenous outward currents in the human embryonic kidney (HEK 293) cell line. J. Neurosci. Methods 81: 73-83
123. - current in rat vascular smooth muscle cells in short-term primary culture. Pflugers Arch. 419: 553-558
124. McDonough S., Davidson N., Lester H. A. and Mccarty N. A. (1994) Novel pore-lining residues in CFTR that govern permeation and openchannel block. Neuron 13: 623-634
125. Schmieder S., Lindenthal S., Banderali U. and Ehrenfeld J. (1998) Characterization of the putative chloride channel xClC-5 expressed in Xenopus laevis oocytes and comparison with endogenous chloride currents. J. Physiol. 511: 379-393
126. Janssen L. J. and Sims S. M. (1994) Spontaneous transient inward currents and rhythmicity in canine and guinea-pig tracheal smooth muscle cells. Pflugers Arch. 427: 473-480
127. Aromataris E. C., Astill D. S., Rychkov G. Y., Bryant S. H., Bretag A. H. and Roberts M. L. (1999) Modulation of the gating of CIC-1 by S-(-)-2-(4-chlorophenoxy) propionic acid. Br. J. Pharmacol. 126: 1375-1382
128. Picollo A., Liantonio A., Didonna M. P., Elia L., Camerino D. C. and Pusch M. (2004) Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO J. 5: 584-589
129. Julien M., Verrier B., Cerutti M., Chappe V., Gole M., Devauchelle G. et al. (1999) Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells. J. Membr. Biol. 168: 229-239
130. Bachmann A., Russ U. and Quast U. (1999) Potent inhibition of the CFTR chloride channel by suramin. Naunyn-Schmiedebergs Arch. Pharmacol. 360: 473-476
131. - on three distinguishable chloride currents activated in T84 intestinal cells. Pflugers Arch. 425: 552-554
132. Maertens C., Droogmans G., Chakraborty P. and Nilius B. (2001) Inhibition of volume-regulated anion channels in cultured endothelial cells by the anti-oestrogens clomiphene and nafoxidine. Br. J. Pharmacol. 132: 135-142
133. Hogg R. C., Wang Q. and Large W. A. (1993) Time course of spontaneous calcium-activated chloride currents in smooth muscle cells from the rabbit portal vein. J. Physiol. 464: 15-31