Inhibition of volume-regulated and calcium-activated chloride channels by the antimalarial mefloquine

Journal of Pharmacology and Experimental Therapeutics

Volumn 295, Issue 1, 2000, Pages 29-36

  Maertens, Chantal ^a   Wei, Lin ^a   Droogmans, Guy ^a   Nilius, Bernd ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CALCIUM ION; CHLORIDE CHANNEL; CHLORIDE ION; CHLOROQUINE; MEFLOQUINE; QUININE; RO 14 6858; RO 21 8812; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTERY ENDOTHELIUM; ARTICLE; CALCIUM TRANSPORT; CATTLE; CELL VOLUME; DRUG MECHANISM; DRUG POTENCY; DRUG SPECIFICITY; HUMAN; HUMAN CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PULMONARY ARTERY; SIDE EFFECT;

ANIMALS; ANTIMALARIALS; CALCIUM; CATTLE; CELLS, CULTURED; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN-ION CONCENTRATION; MEFLOQUINE;

EID: 0033810904     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea
2. Mefloquine prophylaxis: An overview of spontaneous reports of severe psychiatric reactions and convulsions
3. cAMP-activated Cl channels in CFTR-transfected cystic fibrosis pancreatic epithelial cells
4. Polyvariant mutant cystic fibrosis transmembrane conductance regulator genes. The polymorphic (Tg)m locus explains the partial penetrance of the T5 polymorphism as a disease mutation
5. 2+ entry into Plasmodium falciparum-infected blood cells
6. Quinoline antimalarials: Mechanisms of action and resistance and prospects for new agents
7. Antiprotozoal drugs
8. Inhibition of volume-activated chloride currents in endothelial cells by chromones
9. Plasma concentrations of sulfadoxine-pyrimethamine and of mefloquine during regular long term malaria prophylaxis
10. Severe psychiatric side effects observed during prophylaxis and treatment with mefloquine
11. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
12. Transport of lactate in Plasmodium falciparum-infected human erythrocytes
13. In search of a selective inhibitor of the induced transport of small solutes in Plasmodium falciparum-infected erythrocytes: Effects of arylaminobenzoates
14. Novel anion dependence of induced cation transport in malaria-infected erythrocytes
15. Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel
16. Volume-regulatory taurine release from a human lung cancer cell line - Evidence for amino acid transport via a volume-activated chloride channel
17. Functional properties and physiological roles of organic solute channels
18. Swelling-activated efflux of taurine and other organic osmolytes in endothelial cells
19. Properties of volume-regulated anion channels in mammalian cells
20. - channels
21. - current by hypotonic volume increase in human endothelial cells
22. Modulation of volume-regulated anion channels by extra- and intracellular pH
23. Calcium-activated chloride channels in bovine pulmonary artery endothelial cells
24. Kinetic and pharmacological properties of the calcium-activated chloride current in macrovascular endothelial cells
25. Ion channels in vascular endothelium
26. - channel: Fresh start to the molecular identity and volume sensor
27. Mefloquine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy
28. Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria
29. Increased choline transport in erythrocytes from mice infected with the malaria parasite Plasmodium vinckei vinckei
30. Increased permeability of the malaria-infected erythrocyte to organic cations
31. Regulation of solute and water balance and cell volume in the central nervous system
32. Cellular and molecular physiology of volume-sensitive anion channels
33. 2+ concentration
34. Drugs used in the chemotherapy of protozoal infections
35. Use of a bicistronic GFP-expression vector to characterise ion channels after transfection in mammalian cells
36. Differential effects of tamoxifen and I- on three distinguishable chloride currents activated in T84 intestinal cells
37. Membrane currents and the resting membrane potential in cultured bovine pulmonary artery endothelial cells
38. Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine
39. Drugs used in the chemotherapy of protozoal infections