Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 281, Issue 1 25-1, 2001, Pages

  Gao, Lin ^a   Broughman, James R ^b   Iwamoto, Takeo ^b   Tomich, John M ^b   Venglarik, Charles J ^a   Forman, Henry Jay ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Antioxidant; Channel forming peptide; Chlorzoxazone; Glutathione transport

Indexed keywords

CHLORIDE CHANNEL; CHLORZOXAZONE; GLUTATHIONE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

APICAL MEMBRANE; ARTICLE; CHANNEL GATING; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION; RESPIRATORY EPITHELIUM; SHORT CIRCUIT CURRENT;

EID: 0034810698     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.281.1.l24     Document Type: Article

References (34)

1. + channels: Subunit-subunit interactions and inhibition by the cystic fibrosis transmembrane conductance regulator
2. 2-terminal modification of a channel-forming peptide increases capacity for epithelial anion secretion
3. Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress
4. Normal alveolar epithelial lining fluid contains high levels of glutathione
5. Molecular pathophysiology of cystic fibrosis based on the rescued knockout mouse model
6. + channel
7. High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives
8. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes
9. Kinetics and mechanisms of hypochlorous acid reactions
10. Abnormal glutathione transport in cystic fibrosis airway epithelia
11. Direct evidence for the role of the membrane potential in glutathione transport by renal brushborder membranes
12. + conductance by the cystic fibrosis transmembrane conductance regulator
13. CFTR modulates lung secretory cell proliferation and differentiation
14. Renal glutathione transport: Characteristics of the sodium-dependent system in the basal-lateral membrane
15. - channels expressed in a mammalian cell line and its regulation by a critical pore residue
16. Glutathione permeability of CFTR
17. A synthetic peptide based on a glycine-gated chloride channel induces a novel chloride conductance in isolated epithelial cells
18. Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer
19. Sinusoidal efflux of glutathione in the perfused rat liver. Evidence for a carrier-mediated process
20. Purinoceptor activation of chloride transport in cystic fibrosis and CFTR-transfected pancreatic cell lines
21. Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins
22. Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. II. Transmembrane segment M2 of the brain glycine receptor is a plausible candidate for the pore-lining structure
23. Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis
24. Systemic deficiency of glutathione in cystic fibrosis
25. In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR
26. - secretion by chlorzoxazone
27. Oxygen toxicity: Loss of lung macrophage function without metabolite depletion
28. Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function
29. Oxidative stress in cystic fibrosis: Does it occur and does it matter?
30. Cholinergic regulation of Na absorption by turtle colon: Role of basolateral K conductance
31. + channels
32. - and fluid secretion
33. Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype
34. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein