-
1
-
-
0031587276
-
The effects of artificial calcium buffers on calcium responses and glutamate-mediated excitotoxicity in cultured hippocampal neurons
-
K.M. Abdel-Hamid, and K.G. Baimbridge The effects of artificial calcium buffers on calcium responses and glutamate-mediated excitotoxicity in cultured hippocampal neurons Neuroscience 81 1997 673 687
-
(1997)
Neuroscience
, vol.81
, pp. 673-687
-
-
Abdel-Hamid, K.M.1
Baimbridge, K.G.2
-
2
-
-
0036488223
-
Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation
-
C.C. Alano, G. Beutner, R.T. Dirksen, R.A. Gross, and S.S. Sheu Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation J. Neurochem. 80 2002 531 538
-
(2002)
J. Neurochem.
, vol.80
, pp. 531-538
-
-
Alano, C.C.1
Beutner, G.2
Dirksen, R.T.3
Gross, R.A.4
Sheu, S.S.5
-
3
-
-
0026609559
-
Alternative excitotoxic hypotheses
-
R.L. Albin, and J.T. Greenamyre Alternative excitotoxic hypotheses Neurology 42 1992 733 738
-
(1992)
Neurology
, vol.42
, pp. 733-738
-
-
Albin, R.L.1
Greenamyre, J.T.2
-
4
-
-
0025322132
-
Abnormalities of striatal projection neurons and N-methyl-d-aspartate receptors in presymptomatic Huntington's disease [see comments]
-
R.L. Albin, A.B. Young, J.B. Penney, B. Handelin, R. Balfour, K.D. Anderson, D.S. Markel, W.W. Tourtellotte, and A. Reiner Abnormalities of striatal projection neurons and N-methyl-d-aspartate receptors in presymptomatic Huntington's disease [see comments] N. Engl. J. Med. 322 1990 1293 1298
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1293-1298
-
-
Albin, R.L.1
Young, A.B.2
Penney, J.B.3
Handelin, B.4
Balfour, R.5
Anderson, K.D.6
Markel, D.S.7
Tourtellotte, W.W.8
Reiner, A.9
-
5
-
-
0026584524
-
Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
-
M.F. Beal Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31 1992 119 130
-
(1992)
Ann. Neurol.
, vol.31
, pp. 119-130
-
-
Beal, M.F.1
-
6
-
-
0022446150
-
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
-
M.F. Beal, N.W. Kowall, D.W. Ellison, M.F. Mazurek, K.J. Swartz, and J.B. Martin Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid Nature 321 1986 168 171
-
(1986)
Nature
, vol.321
, pp. 168-171
-
-
Beal, M.F.1
Kowall, N.W.2
Ellison, D.W.3
Mazurek, M.F.4
Swartz, K.J.5
Martin, J.B.6
-
7
-
-
0028360309
-
Induction of a common pathway of apoptosis by staurosporine
-
R. Bertrand, E. Solary, P. O'Connor, K.W. Kohn, and Y. Pommier Induction of a common pathway of apoptosis by staurosporine Exp. Cell Res. 211 1994 314 321
-
(1994)
Exp. Cell Res.
, vol.211
, pp. 314-321
-
-
Bertrand, R.1
Solary, E.2
O'Connor, P.3
Kohn, K.W.4
Pommier, Y.5
-
8
-
-
0030919567
-
Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
-
S.E. Browne, A.C. Bowling, U. MacGarvey, M.J. Baik, S.C. Berger, M.M. Muqit, E.D. Bird, and M.F. Beal Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia Ann. Neurol. 41 1997 646 653
-
(1997)
Ann. Neurol.
, vol.41
, pp. 646-653
-
-
Browne, S.E.1
Bowling, A.C.2
MacGarvey, U.3
Baik, M.J.4
Berger, S.C.5
Muqit, M.M.6
Bird, E.D.7
Beal, M.F.8
-
9
-
-
0034705057
-
Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons
-
S.L. Budd, L. Tenneti, T. Lishnak, and S.A. Lipton Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons Proc. Natl. Acad. Sci. U. S. A. 97 2000 6161 6166
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 6161-6166
-
-
Budd, S.L.1
Tenneti, L.2
Lishnak, T.3
Lipton, S.A.4
-
10
-
-
0035282594
-
Loss of normal huntingtin function: New developments in Huntington's disease research
-
E. Cattaneo, D. Rigamonti, D. Goffredo, C. Zuccato, F. Squitieri, and S. Sipione Loss of normal huntingtin function: new developments in Huntington's disease research Trends Neurosci. 24 2001 182 188
-
(2001)
Trends Neurosci.
, vol.24
, pp. 182-188
-
-
Cattaneo, E.1
Rigamonti, D.2
Goffredo, D.3
Zuccato, C.4
Squitieri, F.5
Sipione, S.6
-
11
-
-
0035889535
-
NMDA receptor function in mouse models of Huntington disease
-
C. Cepeda, M.A. Ariano, C.R. Calvert, J. Flores-Hernandez, S.H. Chandler, B.R. Leavitt, M.R. Hayden, and M.S. Levine NMDA receptor function in mouse models of Huntington disease J. Neurosci. Res. 66 2001 525 539
-
(2001)
J. Neurosci. Res.
, vol.66
, pp. 525-539
-
-
Cepeda, C.1
Ariano, M.A.2
Calvert, C.R.3
Flores-Hernandez, J.4
Chandler, S.H.5
Leavitt, B.R.6
Hayden, M.R.7
Levine, M.S.8
-
12
-
-
0034283877
-
Transcriptional dysregulation in Huntington's disease
-
J.H. Cha Transcriptional dysregulation in Huntington's disease Trends Neurosci. 23 2000 387 392
-
(2000)
Trends Neurosci.
, vol.23
, pp. 387-392
-
-
Cha, J.H.1
-
13
-
-
0032971311
-
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin
-
N. Chen, T. Luo, C. Wellington, M. Metzler, K. McCutcheon, M.R. Hayden, and L.A. Raymond Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin J. Neurochem. 72 1999 1890 1898
-
(1999)
J. Neurochem.
, vol.72
, pp. 1890-1898
-
-
Chen, N.1
Luo, T.2
Wellington, C.3
Metzler, M.4
McCutcheon, K.5
Hayden, M.R.6
Raymond, L.A.7
-
14
-
-
3543141113
-
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release
-
Y.S. Choo, G.V. Johnson, M. MacDonald, P.J. Detloff, and M. Lesort Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release Hum. Mol. Genet. 13 2004 1407 1420
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 1407-1420
-
-
Choo, Y.S.1
Johnson, G.V.2
MacDonald, M.3
Detloff, P.J.4
Lesort, M.5
-
15
-
-
18544410106
-
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
-
S.W. Davies, M. Turmaine, B.A. Cozens, M. DiFiglia, A.H. Sharp, C.A. Ross, E. Scherzinger, E.E. Wanker, L. Mangiarini, and G.P. Bates Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation Cell 90 1997 537 548
-
(1997)
Cell
, vol.90
, pp. 537-548
-
-
Davies, S.W.1
Turmaine, M.2
Cozens, B.A.3
Difiglia, M.4
Sharp, A.H.5
Ross, C.A.6
Scherzinger, E.7
Wanker, E.E.8
Mangiarini, L.9
Bates, G.P.10
-
16
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
M. DiFiglia, E. Sapp, K.O. Chase, S.W. Davies, G.P. Bates, J.P. Vonsattel, and N. Aronin Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain Science 277 1997 1990 1993
-
(1997)
Science
, vol.277
, pp. 1990-1993
-
-
Difiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
17
-
-
0023080626
-
Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease
-
R.J. Ferrante, N.W. Kowall, M.F. Beal, J.B. Martin, E.D. Bird, and E.P. Richardson Jr. Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease J. Neuropathol. Exp. Neurol. 46 1987 12 27
-
(1987)
J. Neuropathol. Exp. Neurol.
, vol.46
, pp. 12-27
-
-
Ferrante, R.J.1
Kowall, N.W.2
Beal, M.F.3
Martin, J.B.4
Bird, E.D.5
Richardson Jr., E.P.6
-
18
-
-
0036523110
-
Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease
-
R.J. Ferrante, O.A. Andreassen, A. Dedeoglu, K.L. Ferrante, B.G. Jenkins, S.M. Hersch, and M.F. Beal Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease J. Neurosci. 22 2002 1592 1599
-
(2002)
J. Neurosci.
, vol.22
, pp. 1592-1599
-
-
Ferrante, R.J.1
Andreassen, O.A.2
Dedeoglu, A.3
Ferrante, K.L.4
Jenkins, B.G.5
Hersch, S.M.6
Beal, M.F.7
-
19
-
-
0036898557
-
Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: Role of D1 receptors and DARPP-32
-
J. Flores-Hernandez, C. Cepeda, E. Hernandez-Echeagaray, C.R. Calvert, E.S. Jokel, A.A. Fienberg, P. Greengard, and M.S. Levine Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32 J. Neurophysiol. 88 2002 3010 3020
-
(2002)
J. Neurophysiol.
, vol.88
, pp. 3010-3020
-
-
Flores-Hernandez, J.1
Cepeda, C.2
Hernandez-Echeagaray, E.3
Calvert, C.R.4
Jokel, E.S.5
Fienberg, A.A.6
Greengard, P.7
Levine, M.S.8
-
20
-
-
0033557661
-
Cellular localization of huntingtin in striatal and cortical neurons in rats: Lack of correlation with neuronal vulnerability in Huntington's disease
-
F.R. Fusco, Q. Chen, W.J. Lamoreaux, G. Figueredo-Cardenas, Y. Jiao, J.A. Coffman, D.J. Surmeier, M.G. Honig, L.R. Carlock, and A. Reiner Cellular localization of huntingtin in striatal and cortical neurons in rats: lack of correlation with neuronal vulnerability in Huntington's disease J. Neurosci. 19 1999 1189 1202
-
(1999)
J. Neurosci.
, vol.19
, pp. 1189-1202
-
-
Fusco, F.R.1
Chen, Q.2
Lamoreaux, W.J.3
Figueredo-Cardenas, G.4
Jiao, Y.5
Coffman, J.A.6
Surmeier, D.J.7
Honig, M.G.8
Carlock, L.R.9
Reiner, A.10
-
21
-
-
0037096376
-
Calpain activation in Huntington's disease
-
J. Gafni, and L.M. Ellerby Calpain activation in Huntington's disease J. Neurosci. 22 2002 4842 4849
-
(2002)
J. Neurosci.
, vol.22
, pp. 4842-4849
-
-
Gafni, J.1
Ellerby, L.M.2
-
22
-
-
0037401277
-
Are Huntington's and polyglutamine-based ataxias proteasome storage diseases?
-
G.M. Goellner, and M. Rechsteiner Are Huntington's and polyglutamine-based ataxias proteasome storage diseases? Int. J. Biochem. Cell Biol. 35 2003 562 571
-
(2003)
Int. J. Biochem. Cell Biol.
, vol.35
, pp. 562-571
-
-
Goellner, G.M.1
Rechsteiner, M.2
-
23
-
-
0037131263
-
Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons
-
D. Goffredo, D. Rigamonti, M. Tartari, A. De Micheli, C. Verderio, M. Matteoli, C. Zuccato, and E. Cattaneo Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons J. Biol. Chem. 277 2002 39594 39598
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39594-39598
-
-
Goffredo, D.1
Rigamonti, D.2
Tartari, M.3
De Micheli, A.4
Verderio, C.5
Matteoli, M.6
Zuccato, C.7
Cattaneo, E.8
-
24
-
-
0027198567
-
Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum
-
J.G. Greene, R.H. Porter, R.V. Eller, and J.T. Greenamyre Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum J. Neurochem. 61 1993 1151 1154
-
(1993)
J. Neurochem.
, vol.61
, pp. 1151-1154
-
-
Greene, J.G.1
Porter, R.H.2
Eller, R.V.3
Greenamyre, J.T.4
-
25
-
-
0029875381
-
Mitochondrial defect in Huntington's disease caudate nucleus
-
M. Gu, M.T. Gash, V.M. Mann, F. Javoy-Agid, J.M. Cooper, and A.H. Schapira Mitochondrial defect in Huntington's disease caudate nucleus Ann. Neurol. 39 1996 385 389
-
(1996)
Ann. Neurol.
, vol.39
, pp. 385-389
-
-
Gu, M.1
Gash, M.T.2
Mann, V.M.3
Javoy-Agid, F.4
Cooper, J.M.5
Schapira, A.H.6
-
26
-
-
0141750470
-
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila
-
S. Gunawardena, L.S. Her, R.G. Brusch, R.A. Laymon, I.R. Niesman, B. Gordesky-Gold, L. Sintasath, N.M. Bonini, and L.S. Goldstein Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila Neuron 40 2003 25 40
-
(2003)
Neuron
, vol.40
, pp. 25-40
-
-
Gunawardena, S.1
Her, L.S.2
Brusch, R.G.3
Laymon, R.A.4
Niesman, I.R.5
Gordesky-Gold, B.6
Sintasath, L.7
Bonini, N.M.8
Goldstein, L.S.9
-
27
-
-
0032101287
-
The influence of huntingtin protein size on nuclear localization and cellular toxicity
-
A.S. Hackam, R. Singaraja, C.L. Wellington, M. Metzler, K. McCutcheon, T. Zhang, M. Kalchman, and M.R. Hayden The influence of huntingtin protein size on nuclear localization and cellular toxicity J. Cell Biol. 141 1998 1097 1105
-
(1998)
J. Cell Biol.
, vol.141
, pp. 1097-1105
-
-
Hackam, A.S.1
Singaraja, R.2
Wellington, C.L.3
Metzler, M.4
McCutcheon, K.5
Zhang, T.6
Kalchman, M.7
Hayden, M.R.8
-
28
-
-
0033587760
-
Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity
-
O. Hansson, A. Peters n, M. Leist, P. Nicotera, R.F. Castilho, and P. Brundin Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity Proc. Natl. Acad. Sci. U. S. A. 96 1999 8727 8732
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 8727-8732
-
-
Hansson, O.1
Peters, N.A.2
Leist, M.3
Nicotera, P.4
Castilho, R.F.5
Brundin, P.6
-
29
-
-
0033119156
-
Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels
-
G.E. Hardingham, S. Chawla, F.H. Cruzalegui, and H. Bading Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels Neuron 22 1999 789 798
-
(1999)
Neuron
, vol.22
, pp. 789-798
-
-
Hardingham, G.E.1
Chawla, S.2
Cruzalegui, F.H.3
Bading, H.4
-
30
-
-
10544222019
-
Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype
-
J.G. Hodgson, D.J. Smith, K. McCutcheon, H.B. Koide, K. Nishiyama, M.B. Dinulos, M.E. Stevens, N. Bissada, J. Nasir, I. Kanazawa, C.M. Disteche, E.M. Rubin, and M.R. Hayden Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype Hum. Mol. Genet. 5 1996 1875 1885
-
(1996)
Hum. Mol. Genet.
, vol.5
, pp. 1875-1885
-
-
Hodgson, J.G.1
Smith, D.J.2
McCutcheon, K.3
Koide, H.B.4
Nishiyama, K.5
Dinulos, M.B.6
Stevens, M.E.7
Bissada, N.8
Nasir, J.9
Kanazawa, I.10
Disteche, C.M.11
Rubin, E.M.12
Hayden, M.R.13
-
31
-
-
0033136692
-
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
-
J.G. Hodgson, N. Agopyan, C.A. Gutekunst, B.R. Leavitt, F. LePiane, R. Singaraja, D.J. Smith, N. Bissada, K. McCutcheon, J. Nasir, L. Jamot, X.J. Li, M.E. Stevens, E. Rosemond, J.C. Roder, A.G. Phillips, E.M. Rubin, S.M. Hersch, and M.R. Hayden A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration Neuron 23 1999 181 192
-
(1999)
Neuron
, vol.23
, pp. 181-192
-
-
Hodgson, J.G.1
Agopyan, N.2
Gutekunst, C.A.3
Leavitt, B.R.4
Lepiane, F.5
Singaraja, R.6
Smith, D.J.7
Bissada, N.8
McCutcheon, K.9
Nasir, J.10
Jamot, L.11
Li, X.J.12
Stevens, M.E.13
Rosemond, E.14
Roder, J.C.15
Phillips, A.G.16
Rubin, E.M.17
Hersch, S.M.18
Hayden, M.R.19
-
32
-
-
85009226418
-
A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
-
Huntington Study Group
-
Huntington Study Group A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease Neurology 57 2001 397 404
-
(2001)
Neurology
, vol.57
, pp. 397-404
-
-
-
33
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
Huntington's Disease Collaborative Research Group
-
Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 72 1993 971 983
-
(1993)
Cell
, vol.72
, pp. 971-983
-
-
-
34
-
-
0035940412
-
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
-
Y.J. Kim, Y. Yi, E. Sapp, Y. Wang, B. Cuiffo, K.B. Kegel, Z.H. Qin, N. Aronin, and M. DiFiglia Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis Proc. Natl. Acad. Sci. U. S. A. 98 2001 12784 12789
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 12784-12789
-
-
Kim, Y.J.1
Yi, Y.2
Sapp, E.3
Wang, Y.4
Cuiffo, B.5
Kegel, K.B.6
Qin, Z.H.7
Aronin, N.8
Difiglia, M.9
-
35
-
-
0028824798
-
Staurosporine-induced neuronal apoptosis
-
J.Y. Koh, M.B. Wie, B.J. Gwag, S.L. Sensi, L.M. Canzoniero, J. Demaro, C. Csernansky, and D.W. Choi Staurosporine-induced neuronal apoptosis Exp. Neurol. 135 1995 153 159
-
(1995)
Exp. Neurol.
, vol.135
, pp. 153-159
-
-
Koh, J.Y.1
Wie, M.B.2
Gwag, B.J.3
Sensi, S.L.4
Canzoniero, L.M.5
Demaro, J.6
Csernansky, C.7
Choi, D.W.8
-
36
-
-
0035123249
-
Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity
-
A.D. Kovacs, G. Cebers, A. Cebere, T. Moreira, and S. Liljequist Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity Exp. Neurol. 168 2001 47 62
-
(2001)
Exp. Neurol.
, vol.168
, pp. 47-62
-
-
Kovacs, A.D.1
Cebers, G.2
Cebere, A.3
Moreira, T.4
Liljequist, S.5
-
37
-
-
0033198273
-
Mitochondrial depolarization is not required for neuronal apoptosis
-
A.J. Krohn, T. Wahlbrink, and J.H. Prehn Mitochondrial depolarization is not required for neuronal apoptosis J. Neurosci. 19 1999 7394 7404
-
(1999)
J. Neurosci.
, vol.19
, pp. 7394-7404
-
-
Krohn, A.J.1
Wahlbrink, T.2
Prehn, J.H.3
-
38
-
-
12744265359
-
Characterization of striatal cultures with the effect of QUIN and NMDA
-
U. Kumar Characterization of striatal cultures with the effect of QUIN and NMDA Neurosci. Res. 49 2004 29 38
-
(2004)
Neurosci. Res.
, vol.49
, pp. 29-38
-
-
Kumar, U.1
-
39
-
-
0030793341
-
Expression of NMDA receptor-1 (NR1) and huntingtin in striatal neurons which colocalize somatostatin, neuropeptide Y, and NADPH diaphorase: A double-label histochemical and immunohistochemical study
-
U. Kumar, K. Asotra, S.C. Patel, and Y.C. Patel Expression of NMDA receptor-1 (NR1) and huntingtin in striatal neurons which colocalize somatostatin, neuropeptide Y, and NADPH diaphorase: a double-label histochemical and immunohistochemical study Exp. Neurol. 145 1997 412 424
-
(1997)
Exp. Neurol.
, vol.145
, pp. 412-424
-
-
Kumar, U.1
Asotra, K.2
Patel, S.C.3
Patel, Y.C.4
-
40
-
-
0035127907
-
Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo
-
B.R. Leavitt, J.A. Guttman, J.G. Hodgson, G.H. Kimel, R. Singaraja, A.W. Vogl, and M.R. Hayden Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo Am. J. Hum. Genet. 68 2001 313 324
-
(2001)
Am. J. Hum. Genet.
, vol.68
, pp. 313-324
-
-
Leavitt, B.R.1
Guttman, J.A.2
Hodgson, J.G.3
Kimel, G.H.4
Singaraja, R.5
Vogl, A.W.6
Hayden, M.R.7
-
41
-
-
14844314896
-
Enhanced striatal NR2B-containing N-methyl-d-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease
-
L. Li, T.H. Murphy, M.R. Hayden, and L.A. Raymond Enhanced striatal NR2B-containing N-methyl-d-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease J. Neurophysiol. 92 2004 2738 2746
-
(2004)
J. Neurophysiol.
, vol.92
, pp. 2738-2746
-
-
Li, L.1
Murphy, T.H.2
Hayden, M.R.3
Raymond, L.A.4
-
42
-
-
17344363559
-
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates
-
D. Martindale, A. Hackam, A. Wieczorek, L. Ellerby, C. Wellington, K. McCutcheon, R. Singaraja, P. Kazemi-Esfarjani, R. Devon, S.U. Kim, D.E. Bredesen, F. Tufaro, and M.R. Hayden Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates Nat. Genet. 18 1998 150 154
-
(1998)
Nat. Genet.
, vol.18
, pp. 150-154
-
-
Martindale, D.1
Hackam, A.2
Wieczorek, A.3
Ellerby, L.4
Wellington, C.5
McCutcheon, K.6
Singaraja, R.7
Kazemi-Esfarjani, P.8
Devon, R.9
Kim, S.U.10
Bredesen, D.E.11
Tufaro, F.12
Hayden, M.R.13
-
43
-
-
0036327065
-
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
-
A.V. Panov, C.A. Gutekunst, B.R. Leavitt, M.R. Hayden, J.R. Burke, W.J. Strittmatter, and J.T. Greenamyre Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines Nat. Neurosci. 5 2002 731 736
-
(2002)
Nat. Neurosci.
, vol.5
, pp. 731-736
-
-
Panov, A.V.1
Gutekunst, C.A.2
Leavitt, B.R.3
Hayden, M.R.4
Burke, J.R.5
Strittmatter, W.J.6
Greenamyre, J.T.7
-
44
-
-
0031839233
-
Privileged access to mitochondria of calcium influx through N-methyl-d-aspartate receptors
-
T.I. Peng, and J.T. Greenamyre Privileged access to mitochondria of calcium influx through N-methyl-d-aspartate receptors Mol. Pharmacol. 53 1998 974 980
-
(1998)
Mol. Pharmacol.
, vol.53
, pp. 974-980
-
-
Peng, T.I.1
Greenamyre, J.T.2
-
45
-
-
0031890041
-
Visualization of NMDA receptor-induced mitochondrial calcium accumulation in striatal neurons
-
T.I. Peng, M.J. Jou, S.S. Sheu, and J.T. Greenamyre Visualization of NMDA receptor-induced mitochondrial calcium accumulation in striatal neurons Exp. Neurol. 149 1998 1 12
-
(1998)
Exp. Neurol.
, vol.149
, pp. 1-12
-
-
Peng, T.I.1
Jou, M.J.2
Sheu, S.S.3
Greenamyre, J.T.4
-
46
-
-
0030610192
-
Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis
-
J.H. Prehn, J. Jordan, G.D. Ghadge, E. Preis, M.F. Galindo, R.P. Roos, J. Krieglstein, and R.J. Miller Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis J. Neurochem. 68 1997 1679 1685
-
(1997)
J. Neurochem.
, vol.68
, pp. 1679-1685
-
-
Prehn, J.H.1
Jordan, J.2
Ghadge, G.D.3
Preis, E.4
Galindo, M.F.5
Roos, R.P.6
Krieglstein, J.7
Miller, R.J.8
-
47
-
-
0141705360
-
Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: Implications for the pathogenesis of neurodegenerative diseases
-
A.C. Rego, and C.R. Oliveira Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases Neurochem. Res. 28 2003 1563 1574
-
(2003)
Neurochem. Res.
, vol.28
, pp. 1563-1574
-
-
Rego, A.C.1
Oliveira, C.R.2
-
48
-
-
0001589776
-
Differential loss of striatal projection neurons in Huntington disease
-
A. Reiner, R.L. Albin, K.D. Anderson, C.J. D'Amato, J.B. Penney, and A.B. Young Differential loss of striatal projection neurons in Huntington disease Proc. Natl. Acad. Sci. U. S. A. 85 1988 5733 5737
-
(1988)
Proc. Natl. Acad. Sci. U. S. A.
, vol.85
, pp. 5733-5737
-
-
Reiner, A.1
Albin, R.L.2
Anderson, K.D.3
D'Amato, C.J.4
Penney, J.B.5
Young, A.B.6
-
49
-
-
0031740641
-
Neuronal cell death: An updated view
-
L.L. Rubin Neuronal cell death: an updated view Prog. Brain Res. 117 1998 3 8
-
(1998)
Prog. Brain Res.
, vol.117
, pp. 3-8
-
-
Rubin, L.L.1
-
50
-
-
0024400046
-
The quinolinic acid model of Huntington's disease: Locomotor abnormalities
-
P.R. Sanberg, S.F. Calderon, M. Giordano, J.M. Tew, and A.B. Norman The quinolinic acid model of Huntington's disease: locomotor abnormalities Exp. Neurol. 105 1989 45 53
-
(1989)
Exp. Neurol.
, vol.105
, pp. 45-53
-
-
Sanberg, P.R.1
Calderon, S.F.2
Giordano, M.3
Tew, J.M.4
Norman, A.B.5
-
51
-
-
0032987513
-
Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease
-
E. Sapp, J. Penney, A. Young, N. Aronin, J.P. Vonsattel, and M. DiFiglia Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease J. Neuropathol. Exp. Neurol. 58 1999 165 173
-
(1999)
J. Neuropathol. Exp. Neurol.
, vol.58
, pp. 165-173
-
-
Sapp, E.1
Penney, J.2
Young, A.3
Aronin, N.4
Vonsattel, J.P.5
Difiglia, M.6
-
52
-
-
0031792791
-
Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
-
R. Sattler, M.P. Charlton, M. Hafner, and M. Tymianski Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity J. Neurochem. 71 1998 2349 2364
-
(1998)
J. Neurochem.
, vol.71
, pp. 2349-2364
-
-
Sattler, R.1
Charlton, M.P.2
Hafner, M.3
Tymianski, M.4
-
53
-
-
0032851595
-
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
-
A. Sawa, G.W. Wiegand, J. Cooper, R.L. Margolis, A.H. Sharp, J.F. Lawler Jr., J.T. Greenamyre, S.H. Snyder, and C.A. Ross Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization Nat. Med. 5 1999 1194 1198
-
(1999)
Nat. Med.
, vol.5
, pp. 1194-1198
-
-
Sawa, A.1
Wiegand, G.W.2
Cooper, J.3
Margolis, R.L.4
Sharp, A.H.5
Lawler Jr., J.F.6
Greenamyre, J.T.7
Snyder, S.H.8
Ross, C.A.9
-
54
-
-
18544400323
-
Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
-
E. Scherzinger, R. Lurz, M. Turmaine, L. Mangiarini, B. Hollenbach, R. Hasenbank, G.P. Bates, S.W. Davies, H. Lehrach, and E.E. Wanker Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo Cell 90 1997 549 558
-
(1997)
Cell
, vol.90
, pp. 549-558
-
-
Scherzinger, E.1
Lurz, R.2
Turmaine, M.3
Mangiarini, L.4
Hollenbach, B.5
Hasenbank, R.6
Bates, G.P.7
Davies, S.W.8
Lehrach, H.9
Wanker, E.E.10
-
55
-
-
0028292804
-
GABA synapses formed in vitro by local axon collaterals of nucleus accumbens neurons
-
W.X. Shi, and S. Rayport GABA synapses formed in vitro by local axon collaterals of nucleus accumbens neurons J. Neurosci. 14 1994 4548 4560
-
(1994)
J. Neurosci.
, vol.14
, pp. 4548-4560
-
-
Shi, W.X.1
Rayport, S.2
-
56
-
-
10744227174
-
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
-
E.J. Slow, J. van Raamsdonk, D. Rogers, S.H. Coleman, R.K. Graham, Y. Deng, R. Oh, N. Bissada, S.M. Hossain, Y.Z. Yang, X.J. Li, E.M. Simpson, C.A. Gutekunst, B.R. Leavitt, and M.R. Hayden Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease Hum. Mol. Genet. 12 2003 1555 1567
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1555-1567
-
-
Slow, E.J.1
Van Raamsdonk, J.2
Rogers, D.3
Coleman, S.H.4
Graham, R.K.5
Deng, Y.6
Oh, R.7
Bissada, N.8
Hossain, S.M.9
Yang, Y.Z.10
Li, X.J.11
Simpson, E.M.12
Gutekunst, C.A.13
Leavitt, B.R.14
Hayden, M.R.15
-
57
-
-
10744224530
-
Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport
-
G. Szebenyi, G.A. Morfini, A. Babcock, M. Gould, K. Selkoe, D.L. Stenoien, M. Young, P.W. Faber, M.E. MacDonald, M.J. McPhaul, and S.T. Brady Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport Neuron 40 2003 41 52
-
(2003)
Neuron
, vol.40
, pp. 41-52
-
-
Szebenyi, G.1
Morfini, G.A.2
Babcock, A.3
Gould, M.4
Selkoe, K.5
Stenoien, D.L.6
Young, M.7
Faber, P.W.8
MacDonald, M.E.9
McPhaul, M.J.10
Brady, S.T.11
-
58
-
-
0041963057
-
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1
-
T.S. Tang, H. Tu, E.Y. Chan, A. Maximov, Z. Wang, C.L. Wellington, M.R. Hayden, and I. Bezprozvanny Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1 Neuron 39 2003 227 239
-
(2003)
Neuron
, vol.39
, pp. 227-239
-
-
Tang, T.S.1
Tu, H.2
Chan, E.Y.3
Maximov, A.4
Wang, Z.5
Wellington, C.L.6
Hayden, M.R.7
Bezprozvanny, I.8
-
59
-
-
14044264256
-
Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease
-
T.S. Tang, E. Slow, V. Lupu, I.G. Stavrovskaya, M. Sugimori, R. Llinas, B.S. Kristal, M.R. Hayden, and I. Bezprozvanny Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease Proc. Natl. Acad. Sci. U. S. A. 102 2005 2602 2607
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 2602-2607
-
-
Tang, T.S.1
Slow, E.2
Lupu, V.3
Stavrovskaya, I.G.4
Sugimori, M.5
Llinas, R.6
Kristal, B.S.7
Hayden, M.R.8
Bezprozvanny, I.9
-
60
-
-
17644368893
-
Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease
-
J.M. Van Raamsdonk, J. Pearson, E.J. Slow, S.M. Hossain, B.R. Leavitt, and M.R. Hayden Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease J. Neurosci. 25 2005 4169 4180
-
(2005)
J. Neurosci.
, vol.25
, pp. 4169-4180
-
-
Van Raamsdonk, J.M.1
Pearson, J.2
Slow, E.J.3
Hossain, S.M.4
Leavitt, B.R.5
Hayden, M.R.6
-
62
-
-
0022395922
-
Neuropathological classification of Huntington's disease
-
J.P. Vonsattel, R.H. Myers, T.J. Stevens, R.J. Ferrante, E.D. Bird, and E.P. Richardson Jr. Neuropathological classification of Huntington's disease J. Neuropathol. Exp. Neurol. 44 1985 559 577
-
(1985)
J. Neuropathol. Exp. Neurol.
, vol.44
, pp. 559-577
-
-
Vonsattel, J.P.1
Myers, R.H.2
Stevens, T.J.3
Ferrante, R.J.4
Bird, E.D.5
Richardson Jr., E.P.6
-
63
-
-
0032502715
-
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
-
C.L. Wellington, L.M. Ellerby, A.S. Hackam, R.L. Margolis, M.A. Trifiro, R. Singaraja, K. McCutcheon, G.S. Salvesen, S.S. Propp, M. Bromm, K.J. Rowland, T. Zhang, D. Rasper, S. Roy, N. Thornberry, L. Pinsky, A. Kakizuka, C.A. Ross, D.W. Nicholson, D.E. Bredesen, and M.R. Hayden Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract J. Biol. Chem. 273 1998 9158 9167
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9158-9167
-
-
Wellington, C.L.1
Ellerby, L.M.2
Hackam, A.S.3
Margolis, R.L.4
Trifiro, M.A.5
Singaraja, R.6
McCutcheon, K.7
Salvesen, G.S.8
Propp, S.S.9
Bromm, M.10
Rowland, K.J.11
Zhang, T.12
Rasper, D.13
Roy, S.14
Thornberry, N.15
Pinsky, L.16
Kakizuka, A.17
Ross, C.A.18
Nicholson, D.W.19
Bredesen, D.E.20
Hayden, M.R.21
more..
-
64
-
-
0023690166
-
NMDA receptor losses in putamen from patients with Huntington's disease
-
A.B. Young, J.T. Greenamyre, Z. Hollingsworth, R. Albin, C. D'Amato, I. Shoulson, and J.B. Penney NMDA receptor losses in putamen from patients with Huntington's disease Science 241 1988 981 983
-
(1988)
Science
, vol.241
, pp. 981-983
-
-
Young, A.B.1
Greenamyre, J.T.2
Hollingsworth, Z.3
Albin, R.4
D'Amato, C.5
Shoulson, I.6
Penney, J.B.7
-
65
-
-
0037075624
-
Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
-
M.M. Zeron, O. Hansson, N. Chen, C.L. Wellington, B.R. Leavitt, P. Brundin, M.R. Hayden, and L.A. Raymond Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease Neuron 33 2002 849 860
-
(2002)
Neuron
, vol.33
, pp. 849-860
-
-
Zeron, M.M.1
Hansson, O.2
Chen, N.3
Wellington, C.L.4
Leavitt, B.R.5
Brundin, P.6
Hayden, M.R.7
Raymond, L.A.8
-
66
-
-
1642295805
-
Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease
-
M.M. Zeron, H.B. Fernandes, C. Krebs, J. Shehadeh, C.L. Wellington, B.R. Leavitt, K.G. Baimbridge, M.R. Hayden, and L.A. Raymond Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease Mol. Cell. Neurosci. 25 2004 469 479
-
(2004)
Mol. Cell. Neurosci.
, vol.25
, pp. 469-479
-
-
Zeron, M.M.1
Fernandes, H.B.2
Krebs, C.3
Shehadeh, J.4
Wellington, C.L.5
Leavitt, B.R.6
Baimbridge, K.G.7
Hayden, M.R.8
Raymond, L.A.9
-
67
-
-
0141531987
-
Depletion of wild-type huntingtin in mouse models of neurologic diseases
-
Y. Zhang, M. Li, M. Drozda, M. Chen, S. Ren, R.O. Mejia Sanchez, B.R. Leavitt, E. Cattaneo, R.J. Ferrante, M.R. Hayden, and R.M. Friedlander Depletion of wild-type huntingtin in mouse models of neurologic diseases J. Neurochem. 87 2003 101 106
-
(2003)
J. Neurochem.
, vol.87
, pp. 101-106
-
-
Zhang, Y.1
Li, M.2
Drozda, M.3
Chen, M.4
Ren, S.5
Mejia Sanchez, R.O.6
Leavitt, B.R.7
Cattaneo, E.8
Ferrante, R.J.9
Hayden, M.R.10
Friedlander, R.M.11
-
68
-
-
0035919701
-
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
-
C. Zuccato, A. Ciammola, D. Rigamonti, B.R. Leavitt, D. Goffredo, L. Conti, M.E. MacDonald, R.M. Friedlander, V. Silani, M.R. Hayden, T. Timmusk, S. Sipione, and E. Cattaneo Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease Science 293 2001 493 498
-
(2001)
Science
, vol.293
, pp. 493-498
-
-
Zuccato, C.1
Ciammola, A.2
Rigamonti, D.3
Leavitt, B.R.4
Goffredo, D.5
Conti, L.6
MacDonald, M.E.7
Friedlander, R.M.8
Silani, V.9
Hayden, M.R.10
Timmusk, T.11
Sipione, S.12
Cattaneo, E.13
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