The effectiveness of the O6-alkylguanine-DNA alkyltransferase encoded by the ogtST gene from S. typhimurium in protection against alkylating drugs, resistance to O6-benzylguanine and sensitisation to dibromoalkane genotoxicity

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 497, Issue 1-2, 2001, Pages 111-121

  Abril, Nieves ^a   Luque Romero, Franscisco L ^a   Yamada, Masami ^b   Nohmi, Takehiko ^b   Pueyo, Carmen ^a  

^a Departamento de Bioquimica y Biologia Molecular   (Spain)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Chloroethylnitrosoureas; Dibromoethane; Mutagenicity; O6 alkylguanine DNA alkyltransferase; Salmonella Arar assay

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; ALKYLATING AGENT; CARMUSTINE; LOMUSTINE;

ARTICLE; CHEMOPROPHYLAXIS; GENE THERAPY; GENOTOXICITY; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

ALKANES; ALKYLATING AGENTS; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; DNA DAMAGE; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ETHYLENE DIBROMIDE; GENES, BACTERIAL; GUANINE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENICITY TESTS; MUTAGENS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035909497     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00235-2     Document Type: Article

References (36)

1. Mechanisms of carcinogenesis induced by alkylating agents
2. 6-methylguanine-DNA methyltransferase
3. 6-benzylguanine for patients undergoing surgery for malignant glioma
4. 6-alkylguanine by alkyltransferases
5. Chemoprotection of normal tissues by transfer of drug resistance genes
6. Effect of ogt expression on mutation induction by methyl-, ethyl- and propyl-methanesulphonate in Escherichia coli K-12 strains
7. Expression of the ogt gene in wild-type and ada mutants of E. coli
8. Mutagenesis and DNA repair for alkylation damages in Escherichia coli K-12
9. Contribution of ogt-encoded alkyltransferase to resistance to chloroethylnitrosoureas in nucleotide excision repair-deficient E. coli
10. 6-methylguanine
11. 6-benzylguanine
12. 6-benzylguanine
13. ogt alkyltransferase enhances dibromoalkane mutagenicity in excision repair-deficient E. coli K-12
14. Bacterial and mammalian DNA alkyltransferases sensitize E. coli to the lethal and mutagenic effects of dibromoalkanes
15. 6-methylguanine-DNA methyltransferase
16. A weak adaptive response to alkylation damage in Salmonella typhimurium
17. 6-methylguanine
18. 6-methylguanine-DNA methyltransferases and highly sensitive to mutagenic alkylating agents
19. 6-benzylguanine
20. Comparison of a forward and a reverse mutation assay in Salmonella typhimurium measuring L-arabinose resistance and histidine prototrophy
21. The L-arabinose resistance test with Salmonella typhimurium
22. 6-alkylguanine-DNA alkyltransferase: Protection against alkylating agents and sensitization to dibromoalkanes
23. Mutagenesis in Escherichia coli lacking catalase
24. Differential mutagenicities of 6 N-nitroso-N-alkylurea derivatives in Escherichia coli strains with different DNA-repair capacities
25. Structural requirement for the induction of the adaptive response in E. coli among N-(substituted alkyl)-N-nitrosoureas
26. 6-alkylguanine-DNA alkyltransferase
27. 6-alkylguanine-DNA alkyltransferases from rat liver and E. coli
28. 4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria
29. 4-methylthymine in dodecadeoxyribonucleotides
30. 6-benzylguanine
31. 6-benzylguanine
32. 6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes
33. 6-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in E. coli
34. DNA alkylation repair limits spontaneous base substitution mutations in E. coli
35. Metabolic activation of N-alkylnitrosamines in genetically engineered Salmonella typhimurium expressing CYP2E1 or CYP2A6 together with human NADPH-cytochrome P450 reductase
36. Development of a Salmonella tester strain sensitive to promutagenic N-nitrosamines: Expression of recombinant CYP2A6 and human NADPH-cytochrome P450 reductase in S. typhimurium YG7108