Formation and Mass Spectrometric Analysis of DNA and Nucleoside Adducts by S-(1-Acetoxymethyl)glutathione and by Glutathione S-Transferase-Mediated Activation of Dihalomethanes

Chemical Research in Toxicology

Volumn 17, Issue 1, 2004, Pages 45-54

  Marsch, Glenn A ^a,b   Botta, Sisir ^a   Martin, Martha V ^a   McCormick, W Andrew ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNION UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETOXYMETHYLGLUTATHIONE; ACETIC ACID; ACID PHOSPHATASE; ADENINE; BUFFER; CYTOSINE; DEOXYRIBONUCLEASE II; DIHALOMETHANE DERIVATIVE; DNA; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; GUANINE; METHANE; METHYL CHLORIDE; NUCLEOSIDE DERIVATIVE; PHOSPHODIESTERASE; REAGENT; SOLVENT; SPLEEN EXONUCLEASE; THYMINE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL MUTATION; CARCINOGENICITY; CATALYST; CHEMICAL ANALYSIS; CHEMICAL REACTION; DNA ADDUCT; DNA DAMAGE; DNA DEGRADATION; DNA DETERMINATION; DNA MODIFICATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME MECHANISM; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MOLECULAR MODEL; NONHUMAN; PH; REACTION ANALYSIS; SYNTHESIS; TECHNIQUE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; ENDODEOXYRIBONUCLEASES; ESCHERICHIA COLI; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; HYDROCARBONS, BROMINATED; ISOENZYMES; METHYLENE CHLORIDE; MOLECULAR STRUCTURE; PHOSPHORIC DIESTER HYDROLASES; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRANSFECTION;

BACTERIA (MICROORGANISMS);

EID: 1642539123     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx034156z     Document Type: Article

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