Defensins of vertebrate animals

Current Opinion in Immunology

Volumn 14, Issue 1, 2002, Pages 96-102

  Lehrer, Robert I ^a,b   Ganz, Tomas ^a,b  

^a Department of Medicine ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN; CHEMOKINE; GAMMA INTERFERON; MATRILYSIN;

ANTIMICROBIAL ACTIVITY; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOSTIMULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

EID: 0036467390     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(01)00303-X     Document Type: Review

References (52)

1. Cationic proteins of polymorphonuclear leukocyte lysosomes. II. Composition, properties, and mechanism of antibacterial action
2. Cationic proteins of polymorphonuclear leukocyte lysosomes. I. Resolution of antibacterial and enzymatic activities
3. Paneth cell defensins and innate immunity of the small bowel
4. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins
5. Antibacterial peptides isolated from insects
6. Plant defense peptides
7. Human β-defensin-2
8. The NMR structure of human β-defensin-2 reveals a novel α-helical segment
9. The structure of human β-defensin-2 shows evidence of higher order oligomerization
10. Solution structure of bovine neutrophil β-defensin-12: The peptide fold of the β-defensins is identical to that of the classical defensins
11. The structure of human β defensin-1. New insights into structural properties of β-defensins
12. Defensin-like peptide-2 from platypus venom: Member of a class of peptides with a distinct structural fold
13. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic
14. Human β-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity
15. Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes
16. Discovery of new human β-defensins using a genomics-based approach
17. An antimicrobial peptide gene found in the male reproductive system of rats
18. A novel mouse β-defensin, mBD-6, predominantly expressed in skeletal muscle
19. A novel mouse β defensin, Defb2, which is upregulated in the airways by lipopolysaccharide
20. Mouse β defensin-1 is a functional homolog of human β defensin-1
21. Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs
22. A novel murine β-defensin expressed in tongue, esophagus, and trachea
23. Porcine epithelial β-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations
24. An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides
25. Circular minidefensins and posttranslational generation of molecular diversity
26. Posttranslational processing of defensins in immature human myeloid cells
27. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells
28. Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense
29. Germ-free and colonized mice generate the same products from enteric prodefensins
30. β-defensin expression in human mammary gland epithelia
31. Abundant human β-defensin-1 expression in milk and mammary gland epithelium
32. Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids
33. CD14-dependent lipopolysaccharide-induced β-defensin-2 expression in human tracheobronchial epithelium
34. An essential amino acid induces epithelial β-defensin expression
35. Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens
36. Mouse neutrophils lack defensins
37. The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations
38. Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
39. β-Defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
40. Neutrophil α-defensin human neutrophil peptide modulates cytokine production in human monocytes and adhesion molecule expression in endothelial cells
41. Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
42. Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with L-lysine
43. Dermatan sulphate is released by proteinases of common pathogenic bacteria and inactivates antibacterial α-defensin
44. IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity
45. NMR solution structure of murine CCL20/MIP-3α, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the β-chemokine receptor CCR6
46. Three-dimensional structure of RK-1: A novel α-defensin peptide
47. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3
48. Structural analysis of human β-defensin-1 and its significance in urinary tract infection
49. Gallinacin-3, an inducible epithelial β-defensin in the chicken
50. Protein splicing and autoproteolysis mechanisms
51. Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
52. Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds