PI3-kinase p85α is a target molecule of proline-rich antimicrobial peptide to suppress proliferation of ras-transformed cells

Japanese Journal of Cancer Research

Volumn 92, Issue 9, 2001, Pages 959-967

  Tanaka, K ^a   Fujimoto, Y ^a   Suzuki, M ^a   Suzuki, Y ^a   Ohtake, T ^a   Saito, H ^a   Kohgo, Y ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Actin; Antimicrobial peptide; PI3 kinase; PR 39; Ras

Indexed keywords

ACTIN; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE; PROTEIN P85; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; ANTIMICROBIAL CATIONIC PEPTIDE; HYBRID PROTEIN; PR 39; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOSKELETON; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVITY; ENZYME REPRESSION; GENE ACTIVATION; GENETIC ORGANIZATION; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOGENESIS; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTEIN TARGETING; ANIMAL; BIOSYNTHESIS; CELL DIVISION; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; ENZYME INDUCTION; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MICROFILAMENT; ONCOGENE RAS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MOTIF; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; SWINE; ULTRASTRUCTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; AMINO ACID MOTIFS; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL DIVISION; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; CYTOSKELETON; ENZYME INDUCTION; GENES, RAS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MICROFILAMENTS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECOMBINANT FUSION PROTEINS; SRC HOMOLOGY DOMAINS; SWINE; TRANSFECTION;

EID: 0034740811     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01187.x     Document Type: Article

References (37)

1. Amino acid sequence of PR-39: Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides
2. A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39
3. Peptide antibiotics and their role in innate immunity
4. Syndecan, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds
5. PR-39, a peptide regulator of angiogenesis
6. Proline-rich antimicrobial peptide, PR-39 gene transduction altered invasive activity and actin structure in human hepatocellular carcinoma cells
7. phox
8. Cas
9. Inhibition of ubiquitin-proteasome pathway-mediated IκBα degradation by a naturally occurring antibacterial peptide
10. Reduced expression of syndecan-1 in human hepatocellular carcinoma with high metastatic potential
11. Structural basis for the binding of proline-rich peptides to SH3 domains
12. The GTPase dynamin binds to and is activated by a subset of SH3 domains
13. Ras pathways to cell cycle control and cell transformation
14. Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and ki-ras-transformed fibroblast
15. A cDNA derived from pig bone marrow cells predicts a sequence identical to the intestinal antibacterial peptide PR-39
16. Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
17. Complexes of Ras.GTP with Raf-1 mitogen-activated protein kinase kinase
18. Raf-1 activates MAP kinase kinase
19. Cycline D1 expressin is regulated positively by the p42/p44 MAPK and negatively by the p38/HOG MAPK pathway
20. Regulation of the cell cycle machinery by oncogenic ras
21. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes
22. Ras oncogenes in human cancer
23. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
24. Specific activation of p85-p110 phosphatidylinositol 3-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways
25. Selective activation of the JNK signaling cascade and c-Jun transcription activity by the small GTPases Rac and Cdc42Hs
26. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
27. Rho GTPases and actin cytoskeleton
28. Rho-family GTPases bind to phosphoinositide kinases
29. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
30. Differentiation stage-specific inhibition of the Raf-EK-ERK pathway by Akt
31. Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers
32. Increased connexin-43 and gap junctional communication correlate with altered phenotypic characteristics of cells overexpressing the receptor for hyaluronic acid-mediated motility
33. Targeting signal transduction for disease therapy
34. A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity
35. Mitogen-activated protein kinase antisense oligonucleotide inhibits the growth of human lung cancer cells
36. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
37. In vitro and in vivo ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)