Gene-encoded peptide antibiotics and the concept of innate immunity: An update review

Scandinavian Journal of Immunology

Volumn 48, Issue 1, 1998, Pages 15-25

  Boman, H G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPEPTIDE ANTIBIOTIC AGENT;

ARTICLE; GENE EXPRESSION; IMMUNITY; INSECT; MAMMAL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, NATURAL; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 0031821708     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00343.x     Document Type: Article

References (97)

1. Boman HG. Peptide antibiotics and their role in innate immunity. Annu Rev Immun 1995;13:61-92.
2. Boman H. Peptide antibiotics: holy or heretic grails of innate immunity? Scand J Immunol 1996;43:475-82.
3. Fernandez de Caleya R, Gonzales-Pasqual B, Garcia-Olmedo F, Carbonero P. Susceptibility of phytopathogenic bacteria to wheat purothionins in vitro. Appl. Microbiol 1972;23:998-1000.
4. Broekaert WF, Cammue BPA, DeBolle MFC, Thevissen K, DeSamblanx GW, Osborn RW. Antimicrobial peptides from plants. Crit Rev Plant Sci 1997;16:297-323.
5. Boman HG, Broekaert W. Peptide antibiotics come of age. The Immunologist 1998; in press.
6. Steiner H, Hultmark D, Engström Å, Bennich H, Boman H.G. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 1981;292:246-248.
7. Selsted M.E, Brown DM, DeLange R, Lehrer RI. Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J Biol Chem 1983;258:14485-9.
8. Tossi A. A data base with more than 400 entries (Jan 1998): http://www.bbcm.univ.trieste.it/~tossi/search.html .
9. Boman HG, March J, Goode, J. eds. Antimicrobial Peptides. Ciba Symposium No. 186. Chichester, PO19 IUD, UK: John Wiley & Sons Ltd, 1994.
10. Selsted ME, Ouellette AJ. Defensins in granules and non-phagocytic cells. Trends Cell Biol 1995;5:114-9.
11. Ganz T, Weiss J. Antimicrobial peptides of phagocytes and epithelia. Semin Hematol 1997;34:343-54.
12. Lehrer RI, Bevins CL, Ganz T, In: Ogra PL, Mestecky J, Lamm ME, Strober WM Jr, Bienenstock J, eds. Mucosal Immunology. 2nd edn. New York: Academic Press (in press).
13. Shafer WM, ed. Antibacterial peptide protocols. In: Methods in Molecular Biology, Vol. 78. New Jersey: Humana Press. 1997:259 pp.
14. Boman HG. Antibacterial peptides: key components needed in immunity. Cell 1991;65:205-7.
15. Zasloff M. Antibiotic peptides as mediators of innate immunity. Curr Opin Immun 1992;4:3-7.
16. Fang FC. NO contest: nitroc oxide plays complex roles in infections. ASM News 1997;63:668-73.
17. Andersson M, Gunne H, Agerberth B et al. K-lysin, a novel effector peptide of cytotoxic T and NK cells. structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity. EMBO J 1995;14:1615-25.
18. Russell JP, Diamond G, Tarver AP, Scanlin TF, Bevins CL. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor-∝. Infect Immun 1996;64:565-8.
19. Barra D, Simmaco M. Amphibian skin: a promising resource for antimicrobial peptides. TIBTECH 1995;13:205-9.
20. Hoffmann JA, Reichhart JM, Hetru C. Innate immunity in higher insects. Curr Opin Immunol 1996;8:8-13.
21. Hoffmann JA, Reichhart JM. Drosophila immunity. Tr Cell Biol 1997;7:309-16.
22. Cole AM, Weis P, Diamond G. Isolation and characterizalion of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder. J Biol Chem 1997;272:12008-13.
23. Muta T, Iwanaga S. Tachyplesin and anti-lipopolysaccaride factor. In: Antibacterial peptide protocols: Methods in Molecular Biology. Vol. 78. New Jersey: Humana Press; 1997: 63-71.
24. Zhao CQ, Liaw L, Lee I.H, Lehrer RI. cDNA cloning of three cecropin-like antimicrobial peptides (Styelins) from the tunicate. Styela clava. FEBS Lett 1997;412:144-8.
25. Zhao CQ. Liaw L, Lee IH, Lehrer RI. cDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes. FEBS Lett 1997;410:490-2.
26. Hubert F, Noel T, Roch P. A member of the arthropod defensin family from edible Mediterranean mussels (Mytilus galloprovincialis). Eur J Biochem 1996;240:302-6.
27. Levy O. Antibiotic proteins of polymorphonuclear leukocytes. Eur J Haematol 1996;56:263-77.
28. Boman HG. Cecropins: antibacterial peptides from insects and pigs. In: Hoffmann J, Natori S, Janeway C, eds. Phylogenetic Perspectives in Immunity: The Insect-Host Defense. Austin: RG Landes Biomedical Publisher. 1994:24-37.
29. Kreil G. D-amino acids in animal peptides. Annu Rev Biochem 1997;66:337-45.
30. Tossi A, Tarantino C, Romeo D. Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity. Eur J Biochem 1997;250:549-58.
31. Shin SY, Lee MK, Kim KL, Hahm KS. Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 2 and cecropin A-melittin hybrid peptides. J Pept Res 1997;50:279-85.
32. Lee J-Y, Boman A, Sun C et al. H.G. Antibacterial peptides from pig intestine: Isolation of a mammalian cecropin. Proc Natl Acad Sci USA 1989;86:9159-62.
33. Lockey TD, Ourth DD. Formation of pores in Escherichia coli cell membranes by a cecropin isolated from hemolymph of Heliothis virescens larvae. Eur J Biochem 1996;236:263-71.
34. Fehlbaum P, Bulet P, Chernysh S et al. Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc Nail Acad Sci USA 1996;93:1221-5.
35. Miyasaki KT, Iofel R, Lehrer RI. Sensitivity of periodontal pathogens to the bactericidal activity of synthetic protegrins, antibiotic peptides derived from porcine leukocytes. J Dent Res 1997;76:1453-9.
36. Valore EV, Martin E, Harwig SSL, Ganz T. Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest 1996;97:1624-9.
37. Herwig S, Su Q, Zhang W, Ma Y, Tempst P. Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells. Blood 1996;87:350-64.
38. Mallow EB, Harris A, Salzman N et al. Human enteric defensinsgene structure and developmental expression. J Biol Chem 1996;271:4038-45.
39. Zimmermann GR, Legault P, Selsted ME, Pardi A. Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins. Bio-chemistry 1995;34:13663-71.
40. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997;88:553-60.
41. Bevins CL, Jones DE, Dutra A, Schaffzin J, Muenke M. Human enteric defensin genes: chromosomal map position and a model for possible evolutionary relationships. Genomics 1996;31:95-106.
42. Liu LD, Zhao CQ, Heng HHQ, Ganz T. The human beta-defensin-I and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 1997;43:316-20.
43. Ouellette AJ, Selsted ME. Paneth cell defensins: endogenous peplide components of intestinal host defense. FASEB J 1996;10:1280-9.
44. Porter EM, van Dam E, Valore EV, Ganz T. Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect Immun 1997;65:2396-401.
45. Cornet B, Bonmatin J-M, Hetru C et al. Refined three-dimentional solution structure of insect defensin. Curr Biol 1995;3:435-48.
46. Liepinsh E, Andersson M, Ruysschaert J.M. Otting G. Saposin fold revealed by the NMR structure of NK-lysin. Nature Struct Biology 1997;4:793-95.
47. Scocchi M, Romeo D, Zanetti M. Molecular cloning of Bac 7, a proline- and arginine-rich antimicrobial peptide from bovine neutrophils. FEBS Lett 1994;352:197-200.
48. Gallo RL, Kim KJ, Bernfield M et al. Identification of, a cathelinrelated antimicrobial peptide expressed in the embryonic and adult mouse. J Biol Chem 1997;272:13088-93.
49. Zanetti M, Gennaro R, Romeo D. Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett 1995;374:1 -5.
50. Gudmundsson GH, Magnusson KP, Chowdhary BP, Johansson M, Andersson L, Boman HG. Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39. Proc Natl Acad Sci USA 1995;92:7085-9.
51. Zhao CQ, Ganz T, Lehrer RI. The structure of porcine protegrin genes. FEBS Lett 1995;368:197-202.
52. Zhao C, Ganz T, Lehrer RI. Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39. FEBS Lett 1995;376:130-4.
53. Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem 1996;238:325-32.
54. Sorensen O, Arnljots K, Cowland JB, Bainton DF, Borregaard N. The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood 1997;90:2796-803.
55. Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 1997;89:3503-21.
56. Frohm M, Gunne H, Bergman AC et al. Biochemical and antibacterial analysis of human wound and blister fluid. Eur J Biochem 1996;237:86-92.
57. Sun SC, Faye I. Cecropia immunoresponsive factor, an insect immunoresponsive factor with DNA-binding properties similar to nuclear-factor kappaB. Eur J Biochem 1992;204:885-92.
58. Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequence. Cell 1986;46:705-16.
59. Baldwin S Jr. The NF-kB and IkB proteins: new discoveries and insight. Annu Rev Immunol 1996;14:649-83.
60. Engström Y. Insect immune gene regulation. In: Bray PT, Hultmark D, eds. Molecular Mechanisms of Immune Response in Insects. London: Chapman & Hall; 1997; 211-44.
61. Diamond G, Russell J.P. Bevins CL. Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci USA 1996;93:5156-60.
62. Medzhitov RM. Preston-Hurlburt P. Janeway CAJ. A human homologue of the drosophila toll protein signals activation of adaptive immunity. Nature 1997;388:394-7.
63. Lemaitre B, Kromermetzger E, Michaut L et al. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the drosophila host defense. Proc Natl Acad Sci USA 1995;92:9465-9.
64. Kadalayil L, Petersen UM, Engström Y. Adjacent GATA and kB-like motifs regulate the expression of a Drosophila immune gene. Nucl Acids Res l997;6:1233-9.
65. Roos E, Björklund G, Engström Y. In vivo regulation of tissue specific and LPS inducible expression of Drosophila cecropin genes. Insect Mol Biol 1998;7:1-13.
66. Samakovlis C, Kylsten P, Kimbrell DA, Engström Å, Hultmark D. The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster. EMBO J 1991;10:163-9.
67. Agerberth B, Gunne H, Odeberg J, Kogner P, Boman HG, Gudmundsson GH, FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc Natl Acad Sci USA 1995;92:195-9.
68. Rosetto M, Manetti AGO, Giordano PC et al. Molecular characterization of ceratotoxin c, a novel antibacterial female-specific peptide of the ceratotoxin family from the medfly ceratitis capitata. Eur J Biochem 1996;241:330-7.
69. Bensch KW, Raida M, Magert HJ, Schulzknappe P, Forssmann WG. hBD-1: a novel beta-defensin from human plasma. FEBS Lett 1995;368:331-5.
70. Simmaco M, Boman A, Mangoni ML et al. Inhibition by glucocorticoids of the synthesis of antimicrobial peptides from amphibian skin. FEBS Lett 1997;416:273-5.
71. Merrifield RB, Juvvadi P, Andreu D, Ubach J, Boman A, Boman HG. Retro and retroenantio analogs of cecropin-melittin hybrids. Proc Natl Acad Sci USA 1995;92:3449-53.
72. Merrifield EL, Mitchell SA, Ubach J, Boman HG, Andreu D, Merrilield RB. D-Enantiomers of 15 residue cecropin A -mellitin hybrids. Int J Pept Protein Res 1995;46:214-20.
73. Gazit E, Miller IR, Biggin PC, Sansom MSP, Shai Y. Structure and orientation of the mammalian antibacterial peptide cecropin pi within phospholipid membranes. J Mol Biol 1996;258:860-70.
74. Lohner K, Latal A, Lehrer RI, Ganz T. Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems. Biochemistry 1997;36:1525-31.
75. Silvestro L, Gupta K, Weiser JN, Axelsen PH. The concentration-dependent membrane activity of cecropin A. Biochemistry 1997;36:11452-60.
76. Latal A, Degovics G, Epand RF, Epand RM, Lohner K. Structural aspects of the interaction of peptidyl-glycylleucine-carboxyamide, a highly potent antimicrobial peptide from frog skin, with lipids. Eur J Biochem 1997;248:938-46.
77. de Samblanx GW, Goderis IJ, Thevissen K et al. Mutational analysis of a plant defensin from radish (Raphanus sativus L.) reveals two adjecent sites important for antifungal activity. J Biol Chem 1997;272:1171-9.
78. Fujii G, Selsted ME, Eisenberg D. Defensin promotes fusion and lysis of negatively charged membranes. Protein Sci 1993;2:1301-12.
79. Casteels P, Tempst P. Apidaecin-type peptide antibiotics function through a non-poreforming mechanism involving stereospecificity. Biochem Biophys Res Comm 1994;189:339-45.
80. Boman HG, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of cecropin-PI and PR-39, 2 antibacterial peptides from pig intestine. Infect Immun 1993;61:2978-84.
81. Gallo RL, Ono M, Povsic T et al. Syndecans, cell surface heparin sulfate proteoglycans. are induced by a prolin-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 1994;91:11035-9.
82. Shi JH, Ross CR, Leto TL, Sylte MJ, Mcvey D.S, Blecha F. PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to src homology 3 domains of p47(phox). Proc Natl Acad Sci USA 1996;93:6014-8.
83. Vaara M. Agents that increase permeability of the outer membrane. Microbiol Rev 1992;56:395-411.
84. Groisman EA. How bacteria resist killing by host-defense peptides. Trends Microbiol 1994;2:444-9.
85. Hultmark D, Engström A, Andersson K, Steiner H, Bennich H, Boman HG, Inseet immunity. Attacins, a family of antibacterial proteins from Hyalophora cecropia. EMBO Journal 1983;2:571-6.
86. Carlsson A, Engström P, Palva ET, Bennich H, Attacin, an antibacterial protein from Hyalophora-cecropia, inhibits synthesis of outer membrane proteins in Escherichia-coli by interfering with omp gene transcription. Infect Immun 1991;59:3040-5.
87. Yarus S, Rosen JM, Cole AM, Diamond G. Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice. Proc Natl Acad Sci USA 1996;93:14118-21.
88. Reed WA, Elzer PH, Enright FM, Jaynes JM, Morrey JD, White KL. Interleukin 2 promoter/enhancer controlled expression of a synthetic cecropin-class lytic peptide in transgenic mice and subsequent resistance to Brucella abortus. Transgenic Res 1997;6:337-47.
89. Rosquist R, Magnusson KE, Wolf-Watz H. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J 1994;13:964-72.
90. Klein J. Homology between Immune responses in vertebrates and invertebrates: does it exist? Scand J Immunol 1997;46:558-64.
91. Boman HG, Nilsson I, Rasmuson B. Inducible antibacterial defence system in Drosophila. Nature 1972;237:232-5.
92. Velasco M, Diaz-Guerra M, Diaz-Achirica P, Andreu D, Rivas L, Bosca L. Macrophage triggering with cecropin A and melittinderived peptides induces type II nitric oxide synthase expression. J Immunol 1997;158:4437-43.
93. Richman AM, Dimopoulos G, Seelay D, Kafatos FC, Psamodium activates the innate immune response of Anopheles gambiae mosquitos. EMBO J 1997;16:6114-9.
94. Min KT, Benzer S, Wolbachia, normally a symbiont of Drosophila. can be virulent, causing degeneration and early death. Proc Natl Acad Sci USA 1997;94:10792-6.
95. Gupta R, Golding G. The origin of the eukaryotic cell. TIBS 1996;21:166-71.
96. Sahl HG, Bierbaum G. Lanthabiotics: biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria. Annu Rev Microbiol 1998;67:41-79.
97. Falkow S. What is a pathogen? ASM News 1997;63:359-366.