Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga

Biochemical Journal

Volumn 366, Issue 2, 2002, Pages 405-413

  Li, Shi Sheng ^a   Gullbo, Joachim ^a   Lindholm, Petra ^a   Larsson, Rolf ^a   Thunberg, Eva ^a   Samuelsson, Gunnar ^a   Bohlin, Lars ^a   Claeson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Anticancer; Homology modelling; Mass spectrometry; Polypeptide; Thionin

Indexed keywords

AMINO ACIDS; CELLS; DNA; PHYSIOLOGY; PLANTS (BOTANY);

CYTOTOXIC ACTIVITIES;

PROTEINS;

CYTOTOXIC FACTOR; DNA; DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; THIONINE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; IC 50; KIDNEY CARCINOMA; LYMPHOMA CELL LINE; MASS SPECTROMETRY; NONHUMAN; PHYSIOLOGY; PLANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN ISOLATION; PROTEIN STRUCTURE; VISCUM ALBUM;

AMINO ACID SEQUENCE; BINDING SITES; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOTOXINS; DNA; DNA-BINDING PROTEINS; HELIX-TURN-HELIX MOTIFS; HUMANS; LYMPHOMA; MASS SPECTROMETRY; MISTLETOE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

PHORADENDRON; PHORADENDRON LIGA; SANTALACEAE; VISCUM; VISCUM ALBUM;

EID: 0036712603     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020221     Document Type: Article

References (64)

1. Mistletoe toxins
2. Mistletoe in immunology and the clinic
3. Anticancer research on Loranthaceae plants
4. Potentiation of tumour necrosis factor-α-induced apoptosis by mistletoe lectin
5. Thionins from Viscum album L: Influence of the viscotoxins on the activation of granulocytes
6. Screening of plants of the families Loranthaceae and Viscaceae for toxic proteins
7. Toxic proteins from the mistletoe Dendrophtora clavata II. The amino acid sequence of denclatoxin B
8. Phoratoxin, a toxic protein from the mistletoe Phoradendron tomentosum subsp. macrophyllum (Loranthaceae). The amino acid sequence
9. Phoratoxin B, a toxic protein from the mistletoe Phoradendron tomentosum subsp. macrophyllum
10. Isolation and properties of ligatoxin A, a toxic protein from the mistletoe Phoradendron liga
11. The amino acid sequence of ligatoxin A, from the mistletoe Phoradendron liga
12. Energy minimization for tertiary structure prediction of homologous proteins: α1-purothionin and viscotoxin A3 models from crambin
13. Cytotoxicity of different viscotoxins and extracts from the European subspecies of Viscum album L.
14. In vitro effectiveness of a mistletoe preparation on cytostatic-drug-resistant human leukemia cells
15. Cancer multidrug resistance
16. A rapid fluorometric method for semi-automated determination of cytotoxicity and cellular proliferation of human tumor cell lines in microculture
17. Characterization and analysis of thionin genes
18. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
19. Protein modelling for all
20. NMR structural determination of viscotoxin A3 from Viscum album L.
21. "Ensemble" iterative relaxation matrix approach: A new NMR refinement protocol applied to the solution structure of crambin
22. Accurate protein crystallography at ultra-high resolution: Valence-electron distribution in crambin
23. Refinement of purothionins reveals solute particles important for lattice formation and toxicity. Part 1: Alpha-1-purothionin revisited
24. Refinement of purothionins reveals solute particles important for lattice formation and toxicity. Part 2: Structure of beta-purothionin at 1.7 Ångströms resolution
25. The Protein Data Bank
26. RASMOL: Biomolecular graphics for all
27. Anti-cancer drug characterization using a human cell line panel representing defined type of drug resistance
28. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
29. Proposal for a common nomenclature for sequence ions in mass spectra of peptides
30. Contributions of mass spectrometry to peptide and protein structure
31. Thionins
32. A toxic thionin from Pyrularia pubera: Purification, properties, and amino acid sequence
33. Thionins: Properties, possible biological roles and mechanisms of action
34. Protein structure prediction and structural genomics
35. Structural classification of HTH DNA-binding domains and protein-DNA interaction modes
36. Molecular evolution of helix-turn-helix proteins
37. Synergistic anti-tumor effect of ionomycin and cisplatin against renal cell carcinoma in vitro and in vivo
38. The helix-turn-helix DNA-binding motif
39. Amino acid-base interactions: A three-dimensional analysis of protein-DNA interactions at an atomic level
40. Transcription factors: Structural families and principles of DNA recognition
41. Automatic classification and analysis of αα-turn motifs in proteins
42. Interaction between DNA and viscotoxins - Cytotoxic basic polypeptides from Viscum album L.
43. Cytotoxicity of purothionin-A on various animal cells
44. The cytotoxic plant protein, β-purothionin, forms ion channels in lipid membranes
45. Interactions of thionin from Pyrularia pubera with dipalmitoylphosphatidylglycerol large unilamellar vesicles
46. Accidental cell death and generation of reactive oxygen intermediates in human lymphocytes induced by thionins from Viscum album L.
47. Expression of mitochondrial Apo2.7 molecules and caspase-3 activation in human lymphocytes treated with the ribosome-inhibiting mistletoe lectins and the cell membrane permeabilizing viscotoxins
48. Defying death after DNA damage
49. Digitoxin, in non-toxic concentrations, inhibits proliferation and induces cell death in prostate cancer cell lines
50. Generation of reactive oxygen intermediates (ROI) by the thionins from Viscum album L.
51. Abrogation mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance
52. Antimicrobial peptides from plants
53. Overexpression of an endogenous thionin enhances resistance of Arabidopsis against Fusarium oxysporum
54. Leaf-specific thionins of barley - A novel class of cell wall proteins toxic to plant-pathogenic fungi and possibly involved in the defence mechanism of plants
55. Apoptosis, programmed cell death and the hypersensitive response
56. Isolation and characterization of signal transduction mutants of Arabidopsis thaliana that constituitively activate the octadecanoid pathway and from necrotic microlesions
57. Fatty acid signaling in Arabidopsis
58. Isolation and characterization of cDNAs coding for leat-specific thionins closely related to the endosperm-specific hordothionin of barley (Hordeum vulgare L.)
59. Isolation and determination of amino acid sequence of avenothionin. A new purothionin analogue from oat
60. Investigation of thionins of wheat, barley, rye and oat
61. Polyadenylation site heterogeneity in mRNA encoding the precursor of the barley toxin α-hordothionin
62. Amino acid sequences of the two α-purothionins of hexaploid wheat
63. The classification of amino acid conservation
64. Crystal structure of globular domain of histone H5 and its implications for nucleosome binding