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Volumn 1, Issue 1, 2000, Pages

Epithelial antimicrobial peptides in host defense against infection

Author keywords

cathelicidin; chronic bronchitis; defensin; host defense; infection

Indexed keywords

ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; CAP18 LIPOPOLYSACCHARIDE BINDING PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; DEFENSIN; HISTIDINE RICH PROTEINS; HISTIDINE-RICH PROTEINS; IMMUNOLOGIC FACTOR; PROTEIN;

EID: 0001216086     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/rr25     Document Type: Review
Times cited : (414)

References (63)
  • 1
    • 0029987839 scopus 로고    scopus 로고
    • The instructive role of innate immunity in the aquired immune response.
    • Fearon D, Locksley R. The instructive role of innate immunity in the aquired immune response. Science 1996, 272:50-54.
    • (1996) Science , vol.272 , pp. 50-54
    • Fearon, D.1    Locksley, R.2
  • 2
    • 0034601309 scopus 로고    scopus 로고
    • Advances in immunology: innate immunity.
    • Medzhitov R, Janeway CJ. Advances in immunology: innate immunity. N Engl JMed 2000, 343:338-344.
    • (2000) N Engl JMed , vol.343 , pp. 338-344
    • Medzhitov, R.1    Janeway, C.J.2
  • 4
    • 0033067894 scopus 로고    scopus 로고
    • The Toll-receptor family and control of innate immunity.
    • 10047546
    • Kopp E, Medzhitov R. The Toll-receptor family and control of innate immunity. Curr Opin Immunol 1999, 11:13-18. 10.1016/S0952-7915(99)80003-X, 10047546.
    • (1999) Curr Opin Immunol , vol.11 , pp. 13-18
    • Kopp, E.1    Medzhitov, R.2
  • 5
    • 0033542396 scopus 로고    scopus 로고
    • The Toll of innate immunity on microbial pathogenesis.
    • Modlin R, Brightbill H, Godowski P. The Toll of innate immunity on microbial pathogenesis. New Engl JMed 1999, 340:1834-1835.
    • (1999) New Engl JMed , vol.340 , pp. 1834-1835
    • Modlin, R.1    Brightbill, H.2    Godowski, P.3
  • 6
    • 0032783033 scopus 로고    scopus 로고
    • Differences in the concentrations of small, anionic, antimicrobial peptides in bronchoalveolar lavage fluid and in respiratory epithelia of patients with and without cystic fibrosis.
    • 96733, 10417200
    • Brogden KA, Ackermann MR, McCray PB, Huttner KM. Differences in the concentrations of small, anionic, antimicrobial peptides in bronchoalveolar lavage fluid and in respiratory epithelia of patients with and without cystic fibrosis. Infect Immun 1999, 67:4256-4259. 96733, 10417200.
    • (1999) Infect Immun , vol.67 , pp. 4256-4259
    • Brogden, K.A.1    Ackermann, M.R.2    McCray, P.B.3    Huttner, K.M.4
  • 7
    • 0025959114 scopus 로고
    • Defesins: endogenous antibiotic peptides of animal cells.
    • Lehrer R, Ganz T, Selsted M. Defesins: endogenous antibiotic peptides of animal cells. Cell 1991, 64:229-230.
    • (1991) Cell , vol.64 , pp. 229-230
    • Lehrer, R.1    Ganz, T.2    Selsted, M.3
  • 10
    • 0031898688 scopus 로고    scopus 로고
    • Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.
    • Quayle AJ, Porter EM, Nussbaum AA, Wang YM, Brabec C, Yip KP, Mok SC. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 1998, 152:1247-1258.
    • (1998) Am J Pathol , vol.152 , pp. 1247-1258
    • Quayle, A.J.1    Porter, E.M.2    Nussbaum, A.A.3    Wang, Y.M.4    Brabec, C.5    Yip, K.P.6    Mok, S.C.7
  • 11
    • 0032815762 scopus 로고    scopus 로고
    • A 450-kb contig of defensin genes on human chromosome 8p23.
    • 10375637
    • Linzmeier R, Ho CH, Hoang BV, Ganz T. A 450-kb contig of defensin genes on human chromosome 8p23. Gene 1999, 233:205-211. 10.1016/S0378-1119(99)00136-5, 10375637.
    • (1999) Gene , vol.233 , pp. 205-211
    • Linzmeier, R.1    Ho, C.H.2    Hoang, B.V.3    Ganz, T.4
  • 13
    • 0030942221 scopus 로고    scopus 로고
    • Purification and characterization of defensins from cystic fibrosis sputum.
    • 9098722
    • Soong L, Ganz T, Ellison A, Caughey G. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res 1997, 46:98-102. 10.1007/s000110050114, 9098722.
    • (1997) Inflamm Res , vol.46 , pp. 98-102
    • Soong, L.1    Ganz, T.2    Ellison, A.3    Caughey, G.4
  • 14
    • 0025811874 scopus 로고
    • Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.
    • 51571, 2023943
    • Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL. Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 1991, 88:3952-3956. 51571, 2023943.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3952-3956
    • Diamond, G.1    Zasloff, M.2    Eck, H.3    Brasseur, M.4    Maloy, W.L.5    Bevins, C.L.6
  • 16
    • 0031093274 scopus 로고    scopus 로고
    • Human airway epithelia express a β-defensin.
    • McCray P, Bentley L. Human airway epithelia express a β-defensin. Am JRespir Cell Mol Biol 1997, 16:343-349.
    • (1997) Am JRespir Cell Mol Biol , vol.16 , pp. 343-349
    • McCray, P.1    Bentley, L.2
  • 17
    • 0030949875 scopus 로고    scopus 로고
    • Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis.
    • Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997, 88:553-560.
    • (1997) Cell , vol.88 , pp. 553-560
    • Goldman, M.J.1    Anderson, G.M.2    Stolzenberg, E.D.3    Kari, U.P.4    Zasloff, M.5    Wilson, J.M.6
  • 21
    • 0032169557 scopus 로고    scopus 로고
    • Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.
    • Bals R, Wang X, Wu Z, Freeman, Banfa V, Zasloff M, Wilson J. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 1998, 102:874-880.
    • (1998) J Clin Invest , vol.102 , pp. 874-880
    • Bals, R.1    Wang, X.2    Wu, Z.3    Freeman, B.V.4    Zasloff, M.5    Wilson, J.6
  • 22
    • 0033569410 scopus 로고    scopus 로고
    • A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins.
    • 10521339
    • Tang Y-Q, Yaun J, Osapay G, Osapay C, Tran D, Miller C, Quellette A, Selsted M. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins. Science 1999, 286:498-502. 10.1126/science.286.5439.498, 10521339.
    • (1999) Science , vol.286 , pp. 498-502
    • Tang, Y.-Q.1    Yaun, J.2    Osapay, G.3    Osapay, C.4    Tran, D.5    Miller, C.6    Quellette, A.7    Selsted, M.8
  • 23
    • 0028844134 scopus 로고
    • Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain.
    • 7589491
    • Zanetti M, Gennaro R, Romeo D. Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett 1995, 374:1-5. 10.1016/0014-5793(95)01050-O, 7589491.
    • (1995) FEBS Lett , vol.374 , pp. 1-5
    • Zanetti, M.1    Gennaro, R.2    Romeo, D.3
  • 24
    • 0029893253 scopus 로고    scopus 로고
    • The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.
    • Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem 1996, 238:325-332.
    • (1996) Eur J Biochem , vol.238 , pp. 325-332
    • Gudmundsson, G.H.1    Agerberth, B.2    Odeberg, J.3    Bergman, T.4    Olsson, B.5    Salcedo, R.6
  • 25
    • 0029007198 scopus 로고
    • HCAP-18, a cathelin/probactenecin-like protein of human neutrophil specific granules.
    • 7615076
    • Cowland J, Johnsen A, Borregaard N. hCAP-18, a cathelin/probactenecin-like protein of human neutrophil specific granules. FEBS Lett 1995, 368:173-176. 10.1016/0014-5793(95)00634-L, 7615076.
    • (1995) FEBS Lett , vol.368 , pp. 173-176
    • Cowland, J.1    Johnsen, A.2    Borregaard, N.3
  • 26
    • 0028942078 scopus 로고
    • FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.
    • 42844, 7529412
    • Agerberth B, Gunne H, Odeberg J, Kogner P, Boman HG, Gudmundsson GH. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc Natl Acad Sci USA 1995, 92:195-199. 42844, 7529412.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 195-199
    • Agerberth, B.1    Gunne, H.2    Odeberg, J.3    Kogner, P.4    Boman, H.G.5    Gudmundsson, G.H.6
  • 27
    • 0030956070 scopus 로고    scopus 로고
    • The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders.
    • 9182550
    • Frohm M, Agerberth B, Ahangari G, Stahle-Backdahl M, Liden S, Wigzell H, Gudmundsson GH. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 1997, 272:15258-15263. 10.1074/jbc.272.24.15258, 9182550.
    • (1997) J Biol Chem , vol.272 , pp. 15258-15263
    • Frohm, M.1    Agerberth, B.2    Ahangari, G.3    Stahle-Backdahl, M.4    Liden, S.5    Wigzell, H.6    Gudmundsson, G.H.7
  • 28
    • 0032482980 scopus 로고    scopus 로고
    • The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface.
    • Bals R, Wang X, Zasloff M, Wilson JM. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci US A 1998, 95:9541-9546.
    • (1998) Proc Natl Acad Sci US A , vol.95 , pp. 9541-9546
    • Bals, R.1    Wang, X.2    Zasloff, M.3    Wilson, J.M.4
  • 30
    • 0032708355 scopus 로고    scopus 로고
    • Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide.
    • 96996, 10531270
    • Bals R, Weiner D, Moscioni A, Meegalla R, Wilson J. Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. Infect Immun 1999, 67:6084-6089. 96996, 10531270.
    • (1999) Infect Immun , vol.67 , pp. 6084-6089
    • Bals, R.1    Weiner, D.2    Moscioni, A.3    Meegalla, R.4    Wilson, J.5
  • 31
    • 0023888810 scopus 로고
    • Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.
    • Oppenheim FG, Xu T, McMillian FM, Levitz SM, Diamond RD, Offner GD, Troxler RF. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J Biol Chem 1988, 263:7472-7477.
    • (1988) J Biol Chem , vol.263 , pp. 7472-7477
    • Oppenheim, F.G.1    Xu, T.2    McMillian, F.M.3    Levitz, S.M.4    Diamond, R.D.5    Offner, G.D.6    Troxler, R.F.7
  • 35
    • 0032575664 scopus 로고    scopus 로고
    • Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia.
    • 9731241
    • Hiratsuka T, Nakazato M, Date Y, Ashitani J, Minematsu T, Chino N, Matsukura S. Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun 1998, 249:943-947. 10.1006/bbrc.1998.9239, 9731241.
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 943-947
    • Hiratsuka, T.1    Nakazato, M.2    Date, Y.3    Ashitani, J.4    Minematsu, T.5    Chino, N.6    Matsukura, S.7
  • 37
    • 0032903987 scopus 로고    scopus 로고
    • The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6.
    • 116004, 10225921
    • Frohm Nilsson M, Sandstedt B, Sorensen O, Weber G, Borregaard N, Stahle-Backdahl M. The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6. Infect Immun 1999, 67:2561-2566. 116004, 10225921.
    • (1999) Infect Immun , vol.67 , pp. 2561-2566
    • Frohm Nilsson, M.1    Sandstedt, B.2    Sorensen, O.3    Weber, G.4    Borregaard, N.5    Stahle-Backdahl, M.6
  • 38
    • 0006422025 scopus 로고    scopus 로고
    • The innate immune response of the respiratory epithelium.
    • 10719665
    • Diamond G, Legarda D, Ryan LK. The innate immune response of the respiratory epithelium. Immunol Rev 2000, 173:27-38. 10.1034/j.1600-065X.2000.917304.x, 10719665.
    • (2000) Immunol Rev , vol.173 , pp. 27-38
    • Diamond, G.1    Legarda, D.2    Ryan, L.K.3
  • 39
    • 0034703072 scopus 로고    scopus 로고
    • CD14-dependent LPS-induced β-defensin-2 expression in human tracheobronchial epithelium.
    • 10882713
    • Becker MN, Diamond G, Verghese MW, Randell SH. CD14-dependent LPS-induced β-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem 2000, 275:29731-29736. 10.1074/jbc.M000184200, 10882713.
    • (2000) J Biol Chem , vol.275 , pp. 29731-29736
    • Becker, M.N.1    Diamond, G.2    Verghese, M.W.3    Randell, S.H.4
  • 40
    • 0031446642 scopus 로고    scopus 로고
    • Drosophilahost defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.
    • 25070, 9405661
    • Lemaitre B, Reichhart JM, Hoffmann JA. Drosophilahost defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci U S A 1997, 94:14614-14619. 25070, 9405661, 10.1073/pnas.94.26.14614.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 14614-14619
    • Lemaitre, B.1    Reichhart, J.M.2    Hoffmann, J.A.3
  • 41
    • 0024391711 scopus 로고
    • Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.
    • Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest 1989, 84:553-561.
    • (1989) J Clin Invest , vol.84 , pp. 553-561
    • Lehrer, R.I.1    Barton, A.2    Daher, K.A.3    Harwig, S.S.4    Ganz, T.5    Selsted, M.E.6
  • 45
    • 0033584935 scopus 로고    scopus 로고
    • Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa.
    • 10567263
    • Ernst RK, Yi EC, Guo L, Lim KB, Burns JL, Hackett M, Miller SI. Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science 1999, 286:1561-1565. 10.1126/science.286.5444.1561, 10567263.
    • (1999) Science , vol.286 , pp. 1561-1565
    • Ernst, R.K.1    Yi, E.C.2    Guo, L.3    Lim, K.B.4    Burns, J.L.5    Hackett, M.6    Miller, S.I.7
  • 46
    • 0033605557 scopus 로고    scopus 로고
    • Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides.
    • 10085071
    • Peschel A, Otto M, Jack R, Kalbacher H, Jung G, Götz F. Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. J Biol Chem 1999, 274:8405-8410. 10.1074/jbc.274.13.8405, 10085071.
    • (1999) J Biol Chem , vol.274 , pp. 8405-8410
    • Peschel, A.1    Otto, M.2    Jack, R.3    Kalbacher, H.4    Jung, G.5    Götz, F.6
  • 47
    • 0033976515 scopus 로고    scopus 로고
    • Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract.
    • 97327, 10678986
    • Lysenko ES, Gould J, Bals R, Wilson JM, Weiser JN. Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract. Infect Immun 2000, 68:1664-1671. 97327, 10678986, 10.1128/IAI.68.3.1664-1671.2000.
    • (2000) Infect Immun , vol.68 , pp. 1664-1671
    • Lysenko, E.S.1    Gould, J.2    Bals, R.3    Wilson, J.M.4    Weiser, J.N.5
  • 48
    • 0032539553 scopus 로고    scopus 로고
    • Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.
    • 19198, 9465102
    • Shafer WM, Qu X, Waring AJ, Lehrer RI. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family. Proc Natl Acad Sci USA 1998, 95:1829-1833. 19198, 9465102, 10.1073/pnas.95.4.1829.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1829-1833
    • Shafer, W.M.1    Qu, X.2    Waring, A.J.3    Lehrer, R.I.4
  • 49
    • 0030775610 scopus 로고    scopus 로고
    • Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production.
    • Van Wetering S, Mannesse-Lazeroms SP, Dijkman JH, Hiemstra PS. Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production. J Leukoc Biol 1997, 62:217-226.
    • (1997) J Leukoc Biol , vol.62 , pp. 217-226
    • Van Wetering, S.1    Mannesse-Lazeroms, S.P.2    Dijkman, J.H.3    Hiemstra, P.S.4
  • 51
    • 0024797674 scopus 로고
    • Monocyte-chemotactic activity of defensins from human neutrophils.
    • Territo MC, Ganz T, Selsted ME, Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest 1989, 84:2017-2020.
    • (1989) J Clin Invest , vol.84 , pp. 2017-2020
    • Territo, M.C.1    Ganz, T.2    Selsted, M.E.3    Lehrer, R.4
  • 52
    • 0030038197 scopus 로고    scopus 로고
    • Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils.
    • 8621683
    • Chertov O, Michiel DF, Xu L, Wang JM, Tani K, Murphy WJ, Longo DL, Taub DD, Oppenheim JJ. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem 1996, 271:2935-2940. 10.1074/jbc.271.6.2935, 8621683.
    • (1996) J Biol Chem , vol.271 , pp. 2935-2940
    • Chertov, O.1    Michiel, D.F.2    Xu, L.3    Wang, J.M.4    Tani, K.5    Murphy, W.J.6    Longo, D.L.7    Taub, D.D.8    Oppenheim, J.J.9
  • 54
    • 4243236679 scopus 로고    scopus 로고
    • Role of intra-cellular glutathione in neutrophil defensin-induced IL-8 synthesis and cytotoxicity in airway epithelial cells.
    • Van Wetering S, Rahman I, Hiemstra PS, MacNee W. Role of intra-cellular glutathione in neutrophil defensin-induced IL-8 synthesis and cytotoxicity in airway epithelial cells. Eur Respir J 1998, 12:420s.
    • (1998) Eur Respir J , vol.12 , pp. 420s
    • Van Wetering, S.1    Rahman, I.2    Hiemstra, P.S.3    MacNee, W.4
  • 55
    • 0031662738 scopus 로고    scopus 로고
    • Stimulation of the adherence of Haemophilus influenzae to human lung epithelial cells by antimicrobial neutrophil defensins.
    • Gorter AD, Eijk PP, van Wetering S, Hiemstra PS, Dankert J, van Alphen L. Stimulation of the adherence of Haemophilus influenzae to human lung epithelial cells by antimicrobial neutrophil defensins. J Infect Dis 1998, 178:1067-1074.
    • (1998) J Infect Dis , vol.178 , pp. 1067-1074
    • Gorter, A.D.1    Eijk, P.P.2    van Wetering, S.3    Hiemstra, P.S.4    Dankert, J.5    van Alphen, L.6
  • 56
    • 0033844287 scopus 로고    scopus 로고
    • Human neutrophil defensins selectively chemoattract naive T and immature den-dritic cells.
    • Yang D, Chen Q, Chertov O, Oppenheim JJ. Human neutrophil defensins selectively chemoattract naive T and immature den-dritic cells. J Leukoc Biol 2000, 68:9-14.
    • (2000) J Leukoc Biol , vol.68 , pp. 9-14
    • Yang, D.1    Chen, Q.2    Chertov, O.3    Oppenheim, J.J.4
  • 57
    • 0033452745 scopus 로고    scopus 로고
    • Defensins: key players or bystanders in infection, injury, and repair in the lung?
    • van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS. Defensins: key players or bystanders in infection, injury, and repair in the lung? . J Allergy Clin Immunol 1999, 104:1131-1138.
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 1131-1138
    • van Wetering, S.1    Sterk, P.J.2    Rabe, K.F.3    Hiemstra, P.S.4
  • 59
    • 0029870085 scopus 로고    scopus 로고
    • Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid.
    • Smith J, Travis S, Greenberg E, Welsh M. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 1996, 85:229-236.
    • (1996) Cell , vol.85 , pp. 229-236
    • Smith, J.1    Travis, S.2    Greenberg, E.3    Welsh, M.4
  • 60
    • 0032906408 scopus 로고    scopus 로고
    • The innate immune system in cystic fibrosis lung disease.
    • Bals R, Weiner D, Wilson J. The innate immune system in cystic fibrosis lung disease. J Clin Invest 1999, 103:303-307.
    • (1999) J Clin Invest , vol.103 , pp. 303-307
    • Bals, R.1    Weiner, D.2    Wilson, J.3
  • 61
    • 0033582276 scopus 로고    scopus 로고
    • Mechanisms for induction of acquired host immunity by neutrophil peptide defensins.
    • 15191, 9892688
    • Lillard JW, Boyaka PN, Chertov O, Oppenheim JJ, McGhee JR. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc Natl Acad Sci USA 1999, 96:651-656. 15191, 9892688, 10.1073/pnas.96.2.651.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 651-656
    • Lillard, J.W.1    Boyaka, P.N.2    Chertov, O.3    Oppenheim, J.J.4    McGhee, J.R.5
  • 63
    • 0028933794 scopus 로고
    • Peptide antibiotics and their role in innate immunity.
    • 7612236
    • Boman HG. Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 1995, 13:61-92. 10.1146/annurev.iy.13.040195.000425, 7612236.
    • (1995) Annu Rev Immunol , vol.13 , pp. 61-92
    • Boman, H.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.