Antisense inhibition of chondrocyte CD44 expression leading to cartilage chondrolysis

Arthritis and Rheumatism

Volumn 41, Issue 8, 1998, Pages 1411-1419

  Chow, Geraldine ^a,b   Nietfeld, J Jaap ^c   Knudson, Cheryl B ^b   Knudson, Warren ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b RUSH MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; HERMES ANTIGEN; HYALURONIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CATTLE; CELL METABOLISM; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD44; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; MALE; OLIGONUCLEOTIDES, ANTISENSE; OSTEOARTHRITIS; THIONUCLEOTIDES; TIME FACTORS;

EID: 0031876262     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199808)41:8<1411::AID-ART10>3.0.CO;2-Z     Document Type: Article

References (48)

1. Kuettner KE. Osteoarthritis: cartilage integrity and homeostasis. In: Klippel JH, Dieppe PA, editors. Rheumatology. St. Louis: Mosby-Year Book Europe Limited; 1994. p. 6.1-6.16.
2. Hascall VC, Hascall GK. Proteoglycans. In: Hay ED, editor. Cell biology of the extracellular matrix. New York: Plenem Press; 1981. p. 39-63.
3. Heinegard D, Paulsson M. Structure and metabolism of proteoglycans. In: Piez KA, Reddi AH, editors. Extracellular matrix biochemistry. New York: Elsevier; 1984. p. 277-328.
4. Broom ND. An enzymatically induced structural transformation in articular cartilage: its significance with respect to matrix breakdown. Arthritis Rheum 1988;31:210-8.
5. Williams JM, Ongchi DR, Thonar EJ-MA. Repair of articular cartilage injury following intra-articular chymopapain-induced matrix proteoglycan loss. J Orthop Res 1993;11:705-16.
6. Hering TM, Johnstone B, Huynh TD, Huang A, Kollar J. Differentially expressed chondrocyte gene products following extracellular matrix depletion by trypsin [abstract]. Orthop Trans 1996;21: 124.
7. Tyler JA. Articular cartilage cultured with catabolin (pig interleukin 1) synthesized a decreased number of normal proteoglycan molecules. Biochem J 1985;227:869-78.
8. Aydelotte MB, Raiss RX, Schleyerbach R, Kuettner KE. Effects of interleukin-1 on metabolism of proteoglycans by cultured bovine articular chondrocytes [abstract]., Orthop Trans 1988;13:247.
9. Knudson CB. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix. J Cell Biol 1993;120:825-34.
10. Chow G, Knudson CB, Homandberg G, Knudson W. Increased CD44 expression in bovine articular chondrocytes by catabolic cellular mediators. J Biol Chem 1995;270:27734-41.
11. Knudson W, Aguiar DJ, Hua Q, Knudson CB. CD44-anchored hyaluronan-rich pericellular matrices: an ultrastructural and biochemical analysis. Exp Cell Res 1996;228:216-28.
12. Knudson CB, Harwick LC, Aguiar DJ. Retention of chondrocyte pericellular matrix in situ requires interaction with hyaluronan receptors [abstract]. Orthop Trans 1994;19:360.
13. Knudson W, Chow G, Chubinskaya S, Cole AA, Huch K, Kuettner KE, et al. Elevated expression of CD44 in normal human articular cartilage as visualized by in situ hybridization [abstract]. Orthop Trans 1995;20:375.
14. Isacke CM. The role of the cytoplasmic domain in regulating CD44 function. J Cell Sci 1994;107:2353-9.
15. Lokeshwar VB, Fregien N, Bourguignon LYW. Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function. J Cell Biol 1994;126: 1099-109.
16. Tsukita S, Oishi K, Sato N, Sagara J, Kawai A. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol 1994;126: 391-401.
17. Knudson CB, Constable CT, Nofal GA. Changes in phosphorylation and actin-association of CD44 with receptor occupancy on articular chondrocytes. Orthop Trans 1997;22:34.
18. Speir E, Epstein SE. Inhibition of smooth muscle cell proliferation by an antisense oligodeoxynucleotide targeting the messenger RNA encoding proliferating cell nuclear antigen. Circulation 1992;86:538-47.
19. Soprano KJ, Cosenza SC, Yumet G. Use of antisense oligonucleotides to study the role of c-jun in G1 progression. Ann N Y Acad Sci 1992;660:231-9.
20. Krieg AM. Uptake and efficiency of phosphodiester and modified antisense oligonucleotides in primary cell cultures. Clin Chem 1993;39:710-2.
21. Nestle FO, Mitra RS, Bennett CF, Chan H, Nickoloff BJ. Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes. J Invest Dermatol 1994;103:569-75.
22. Nietfeld JJ, Duits AJ, Tilanus MGJ, van den Bosch ME, den Otter W, Capel PJA, et al. Antisense oligonucleotides, a novel tool for the control of cytokine effects on human cartilage: focus on interleukins 1 and 6 and proteoglycan synthesis. Arthritis Rheum 1994;37:1357-62.
23. Jachimczak P, Fabel-Schulte K, Hebdorfer B, Brysch W, Schlingensiepen K-H, Blesch A, et al. Transforming growth factor-B-mediated regulation of human peripheral blood mononuclear cell proliferation as detected with phosphorothioate antisense oligonucleotides. Cell Immunol 1995;165:125-33.
24. Nugent P, Greene RM. Antisense oligonucleotides to CRABP I and II alter expression of TGF-B3, RAR-B, and tenascin in primary cultures of embryonic palate cells. In Vitro Cell Dev Biol 1995;31:553-8.
25. Pampfer S, Vanderheyden I, Vesela J, De Hertogh R. Neutralization of tumor necrosis factor a (TNFa) action on cell proliferation in rat blastocysts by antisense oligodeoxyribonucleotides directed against TNFa p60 receptor. Biol Reprod 1995;52:1316-26.
26. Inui T, Ishibashi O, Inaoka T, Origane Y, Kumegawa M, Kokubo T, et al. Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption. J Biol Chem 1997;272:8109-12.
27. Woolf TM, Jennings CG, Rebagliati M, Melton DA. The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in xenopus oocytes and embryos. Nucleic Acids Res 1990;18:1763-9.
28. Agrawal S, Temsamani J, Tang JY. Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc Natl Acad Sci U S A 1991;88:7595-9.
29. Stein CA, Tonkinson JL, Yakubov L. Phosphorothioate oligodeoxynucleotides anti-sense inhibitors of gene expression? Pharmacol Ther 1991;52:365-84.
30. Fosang AJ, Last K, Maciewicz RA. Aggrecan is degraded by matrix metalloproteinases in human arthritis. J Clin Invest 1996; 98:2292-9.
31. Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, et al. Aggrecan degradation in human cartilage. J Clin Invest 1997;100:93-105.
32. Aydelotte MB, Schumacher BL, Kuettner KE. Heterogeneity of articular chondrocytes. In: Kuettner KE, Schleyerbach R, Peyron JG, Hascall VC, editors. Articular cartilage and osteoarthritis. New York: Raven Press; 1992. p. 237-50.
33. Hauselmann HJ, Aydelotte MB, Thonar EJM, Gitelis SH, Kuettner KE. Alginate beads: a new culture system for articular chondrocytes. In: Kuettner KE, Schleyerbach R, Peyron JG, Hascall VC, editors. Articular cartilage and osteoarthritis. New York: Raven Press; 1992. p. 701-2.
34. Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, et al. Cell-mediated catabolism of aggrecan. J Biol Chem 1995;270:2550-6.
35. Bosworth BT, St. John T, Gallatin WM, Harp JA. Sequence of the bovine CD44 cDNA: comparison with human and mouse sequences. Mol Immunol 1991;28:1131-5.
36. Pearson WR, Lipman DJ. Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A 1988;85:2444-8.
37. Li XQ, Thonar EJ-MA, Knudson W. Accumulation of hyaluronate in human lung carcinoma as measured by a new hyaluronate ELISA. Connect Tissue Res 1989;19:243-53.
38. Laemmli UK. Cleavage of structural proteins during the assembly of bacteriophage T4. Nature 1970;227:680-5.
39. Hauselmann HJ, Fernandes RJ, Mok SS, Schmid TM, Block JA, Aydelotte MB, et al. Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads. J Cell Sci 1994;107:17-27.
40. Sullivan SM, Gieseler RKH, Lenzner S, Ruppert J, Gabrysiak TG, Peters H, et al. Inhibition of human immunodeficiency virus-1 proliferation by liposome-encapsulated sense DNA to the 5′ TAT splice acceptor site. Antisense Res Dev 1992;2:187-97.
41. Aguiar DJ, Mikecz K, Knudson CB. CD44/HA receptor turnover on "matrix-intact" and "matrix-free" adult bovine articular chondrocytes. Orthop Trans 1996;21:86.
42. Fennel DA. Quantitative antisense dose-response relationships: mathematical modeling of antisense action under steady-state conditions. Antisense Nucleic Acid Dev 1997;7:49-53.
43. Zelphati O, Szoka FC. Liposomes as a carrier for intracellular delivery of antisense oligonucleotides. J Control Release 1996;1-2:99-119.
44. Ma DDF, Wei AQ. Enhanced delivery of synthetic oligonucleotides to human leukaemic cells by liposomes and immunoliposomes. Leukemia Res 1996;20:925-30.
45. Wu-Pong S, Weiss TL, Hunt CA. Calcium dependent cellular uptake of a c-myc antisense oligonucleotide. Cell Mol Biol 1994; 40:843-50.
46. Kaya G, Rodriguez I, Jorcano JL, Vassalli P, Stamenkovic I. Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Genes Dev 1997;11:996-1007.
47. Hua Q, Knudson CB, Knudson W. Internalization of hyaluronan by chondrocytes occurs via receptor-mediated endocytosis. J Cell Sci 1993;106:365-75.
48. Homandberg G, Meyers R, Xie DL. Fibronectin fragments causes chondrolysis of bovine articular cartilage slices in culture. J Biol Chem 1992;267:3597-604.