Age-related decrease in the responsiveness of rat articular chondrocytes to EGF is associated with diminished number and affinity for the ligand of cell surface binding sites

Mechanisms of Ageing and Development

Volumn 100, Issue 1, 1998, Pages 25-40

  Ribault, Didier ^a   Habib, Messai ^a   Abdel Majid, Khatib ^a   Barbara, Alain ^a   Mitrovic, Dragoslav ^a  

^a INSERM   (France)

Author keywords

Aging; DNA synthesis; EGF and EGF receptor mRNAs expressions; EGF receptor; Epidermal growth factor; Rat articular chondrocytes

Indexed keywords

COLLAGENASE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IODINE 125; MESSENGER RNA;

AGING; ANIMAL CELL; ARTICLE; BINDING SITE; CARTILAGE CELL; CELL CULTURE; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA CONTENT; DNA SYNTHESIS; DOWN REGULATION; FEMUR; HUMERUS; MALE; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; BINDING SITES; CARTILAGE, ARTICULAR; CELL MEMBRANE; CELLS, CULTURED; DNA; EPIDERMAL GROWTH FACTOR; LIGANDS; MALE; RATS; RATS, WISTAR; RECEPTOR, EPIDERMAL GROWTH FACTOR;

ANIMALIA;

EID: 0032509782     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(97)00115-2     Document Type: Article

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