Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

EMBO Journal

Volumn 23, Issue 11, 2004, Pages 2185-2195

  Heo, Yong Seok ^a,b   Kim, Su Kyoung ^a   Seo, Chang Il ^a   Kim, Young Kwan ^a   Sung, Byung Je ^a   Lee, Hye Shin ^a   Lee, Jae Il ^a   Park, Sam Yong ^c   Kim, Jin Hwan ^a   Hwang, Kwang Yeon ^a   Hyun, Young Lan ^a   Jeon, Young Ho ^a   Ro, Seonggu ^a   Cho, Joong Myung ^a   Lee, Tae Gyu ^a   Yang, Chu Hak ^b  

^a CrystalGenomics Inc   (South Korea)

^b Seoul National University   (South Korea)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Docking site; JIP1; JNK; Scaffolding protein; SP600125

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARGININE; C JUN N TERMINAL KINASE INTERACTING PROTEIN 1; GLUTAMIC ACID; LEUCINE; MITOGEN ACTIVATED PROTEIN KINASE; PEPJIP1 PROTEIN; PEPTIDE FRAGMENT; PROLINE; PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; C TERMINAL DOMAIN; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYDROGEN BOND; N TERMINAL DOMAIN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANTHRACENES; ARGININE; BINDING SITES; BLOTTING, WESTERN; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; HELA CELLS; HUMANS; HYDROGEN BONDING; LEUCINE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MODELS, MOLECULAR; PROLINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 3042689209     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600212     Document Type: Article

References (43)

1. Bain J, McLauchlan H, Elliott M, Cohen P (2003) The specificities of protein kinase inhibitors: an update. Biochem J 371: 199-204
2. Bardwell AJ, Flatauer LJ, Matsukuma K, Thomer J, Bardwell L (2001) A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem 276: 10374-10386
3. Barr RK, Kendrick TS, Bogoyevitch MA (2002) Identification of the critical features of a small peptide inhibitor of JNK activity. J Biol Chem 277: 10987-10997
4. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98: 13681-13686
5. Bonny C, Oberson A, Negri S, Sauser C, Schorderet DF (2001) Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50: 77-82
6. Bozyczko-Coyne D, Saporito MS, Hudkins RL (2002) Targeting the JNK pathway for therapeutic benefit in CNS disease. Curr Drug Target CNS Neurol Disord 1: 31-49
7. Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ, Serrano M, Brenner SL, Blundell TL, Laue ED (1998) Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature 395: 244-250
8. Brünger AT, Adams PD, Clore GM, DeLano WL, Gros P, Grosse-Kunstleve RW, Jiang JS, Kuszewski J, Nilges M, Pannu NS, Read RJ, Rice LM, Simonson T, Warren GL (1998) Crystallography and NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr D 54: 905-921
9. Chang CI, Xu BE, Akella R, Cobb MH, Goldsmith EJ (2002) Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol Cell 9: 1241-1249
10. Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252
11. Dickens M, Roger JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyer CL, Davis RJ (1997) A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277: 693-696
12. Elion EA (1998) Routing MAP kinase cascade. Science 281: 1625-1626
13. Faux MC, Scott JD (1996) Molecular glue: kinase anchoring and scaffold proteins. Cell 85: 9-12
14. Garrington TP, Johnson GL (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11: 211-218
15. Goldsmith EJ (1996) Allosteric enzymes as models for chemomechanical energy transducing assemblies. FASEB J 10: 702-708
16. Gum R, Wang H, Lengyel E, Juarez J, Boyd D (1997) Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades. Oncogene 14: 1481-1493
17. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 15: 2760-2770
18. Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS (2002) Joint damage and inflammation in c-jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum 46: 818-823
19. Heras B, Edeling MA, Byriel KA, Jones A, Raina S, Martin JL (2003) Dehydration converts DsbG crystal diffraction from low to high resolution. Structure 11: 139-145
20. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS (2002) A central role for JNK in obesity and insulin resistance. Nature 420: 333-336
21. Ho DT, Bardwell AJ, Abdollahi M, Bardwell L (2003) A docking site in MKK4 mediates high-affinity binding to JNK MAP kinases and competes with similar docking sites in JNK substrates. J Biol Chem 278: 32662-32672
22. Holland PM, Cooper JA (1999) Protein modification: docking sites for kinases. Curr Biol 9: R329-R331
23. Kemp BE, Pearson RB (1991) Design and use of peptide substrates for protein kinases. Methods Enzymol 200: 121-134
24. Kim IJ, Lee KW, Park BY, Lee JK, Park J, Choi IY, Eom SJ, Chang TS, Kim MJ, Yeom YI, Chang SK, Lee YD, Choi EJ, Han PL (1999) Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain. J Neurochem 72: 1335-1343
25. Manning AM, Davis RJ (2003) Targeting JNK for therapeutic benefit: from junk to gold? Nat Rev Drug Discov 2: 554-565
26. Martin JH, Mohit AA, Miller CA (1996) Developmental expression in the mouse nervous system of the p493F12 SAP kinase. Brain Res Mol Brain Res 35: 47-57
27. Mochly-Rosen D (1995) Localization of protein kinases by anchoring protein: a theme in signal transduction. Science 268: 247-251
28. Mohit AA, Martin JH, Miller CA (1995) p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 14: 67-78
29. Pawson T (1995) Protein modules and signaling networks. Nature 373: 573-580
30. Pawson T, Scott JD (1997) Signalling through scaffold, anchoring, and adaptor proteins. Science 278: 2075-2080
31. Russo AA, Tong L, Lee JO, Jeffrey PD, Pavletich NP (1998) Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395: 237-243
32. Scapin G, Patel SB, Lisnock J, Becker JW, LoGrasso PV (2003) The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity. Chem Biol 10: 705-712
33. Sharrocks AD, Yang SH, Galanis A (2000) Docking domains and substrate-specificity determination for MAP kinases. Trends Biochem Sci 25: 448-453
34. Smith JA, Poteet-Smith CE, Lannigan DA, Freed TA, Zoltoski AJ, Sturgill TW (2000) Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function. J Biol Chem 275: 31588-31593
35. Tanoue T, Maeda R, Adachi M, Nishida E (2001) Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions. EMBO J 20: 466-479
36. Tanoue T, Nishida E (2002) Docking interactions in the mitogen-activated protein kinase cascades. Pharmacol Ther 93: 193-202
37. 2-terminal kinase kinases. Mol Cell Biol 19: 1569-1581
38. Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA (2001) beta-Amyloid-induced neuronal apoptosis requires c-jun N-terminal kinase activation. J Neurochem 77: 157-164
39. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, Hani EH, Vionnet N, Nicod P, Boutin P, Froguel P (2000) The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nat Genet 24: 291-295
40. Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ (1998) A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281: 1671-1674
41. Xie X, Gu Y, Fox T, Coll JT, Fleming MA, Markland W, Caron PR, Wilson KP, Su MS (1998) Crystal structure of JNK3: a kinase implicated in neuronal apoptosis. Structure 6: 983-991
42. Yang S-H, Whitmarsh AJ, Davis RJ, Sharrocks AD (1998) Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J 17: 1740-1749
43. Zhu X, Lee HG, Raina AK, Perry G, Smith MA (2002) The role of mitogen-activated protein kinase pathways in Alzheimer's disease. Neurosignals 11: 270-281