Flavanol-rich cocoa drink lowers plasma F2-isoprostane concentrations in humans

Free Radical Biology and Medicine

Volumn 37, Issue 3, 2004, Pages 411-421

  Wiswedel, Ingrid ^a   Hirsch, Daniela ^a   Kropf, Siegfried ^a   Gruening, Martin ^a   Pfister, Eberhard ^a   Schewe, Tankred ^b   Sies, Helmut ^b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Antioxidants; Exercise; F2 isoprostanes; Flavonoids; Free radicals; Human study; Lipid peroxidation; Oxidative stress; Procyanidins

Indexed keywords

FLAVANOL DERIVATIVE; ISOPROSTANE;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; CACAO; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESTERIFICATION; EXERCISE; FATTY ACID BLOOD LEVEL; GAS CHROMATOGRAPHY; HUMAN; INGESTION; MALE; MASS SPECTROMETRY; OXIDATIVE STRESS; POSTPRANDIAL STATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE;

ADULT; ANTIOXIDANTS; BEVERAGES; CACAO; CATECHIN; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EXERCISE; F2-ISOPROSTANES; FATTY ACIDS; FLAVONOIDS; HUMANS; LIPID PEROXIDATION; MALE;

STAPHYLOCOCCUS PHAGE 187; THEOBROMA CACAO;

EID: 3042540223     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.05.013     Document Type: Article

References (52)

1. Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet. 342:1993;1007-1011
2. Knekt P., Järvinen R., Reunanen A., Maatela J. Flavonoid intake and coronary mortality in Finland: a cohort study. Br. Med. J. 312:1996;478-481
3. Joshipura K.J., Hu F.B., Manson J.E., Stampfer M.J., Rimm E.B., Speizer F.E., Colditz G., Ascherio A., Rosner B., Spiegelman D., Willett W.C. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann. Intern. Med. 134:2001;1106-1114
4. Knekt P., Kumpulainen J., Järvinen R., Rissanen H., Heliövaara M., Reunanen A., Hakulinen T., Aromaa A. Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 76:2002;560-568
5. Maron D.J. Flavonoids for reduction of atherosclerotic risk. Curr. Atheroscl. Rep. 6:2004;73-78
6. Colditz G., Ascherio A., Rosner B., Spiegelman D., Willett W.C. Tea flavonoids and cardiovascular healt. Q. J.Med. 94:2001;277-282
7. Duffy S.J., Keaney J.F. Jr., Holbrook M., Gokce N., Swerdloff P.I., Frei B., Vita J.A. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation. 104:2001;151-156
8. Rietfeld A., Wiseman S. Antioxidant effects of tea: evidence from human clinical trials. J. Nutr. 133:2003;3285S-3292S
9. Folts J.D. Potential health benefits from the flavonoids in grape products on vascular disease. Adv. Exp. Med. Biol. 505:2002;95-111
10. Schramm D.D., Wang J.F., Holt R.R., Ensunsa J.L., Gonsalves J.L., Lazarus S.A., Schmitz H.H., German J.B., Keen C.L. Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am. J. Clin. Nutr. 73:2001;36-40
11. Steinberg F.M., Bearden M.M., Keen C.L. Cocoa and chocolate flavonoids: implications for cardiovascular health. J. Am. Diet. Assoc. 103:2003;215-223
12. Fisher N.D.L., Hughes M., Gerhard-Herman M., Hollenberg N.K. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J. Hypertens. 21:2003;2281-2286
13. Meursing E.H., Zijderveld J.A. Cocoa mass, cocoa butter, and cocoa powder. Becket S.T. Industrial chocolate manufacturing and use. 1994;101-114 Blackie Academic and Professional, Glasgow, UK
14. Rechner A., Kuhnle G., Bremner P., Hubbard G.P., Moore K.P., Rice-Evans C.A. The metabolic fate of dietary polyphenols in humans. Free Radic. Biol. Med. 33:2002;220-235
15. Witztum J.L., Steinberg D. Role of oxidized low-density lipoprotein in atherogenesis. J. Clin. Invest. 88:1991;1785-1792
16. Berliner J.A., Heinecke J.W. The role of oxidized lipoproteins in atherogenesis. Free Radic. Biol. Med. 20:1996;707-727
17. 2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol. 300:1999;3-12
18. Morrow J.D., Zackert W.E., Van der Ende D.S., Reich E.E., Terry E.S., Cox B., Sanchez S.C., Montine T.J., Roberts L.J. Quantification of isoprostanes as indicators of oxidative stress. Cadenas E., Packer L. Handbook of antioxidants. second edition:2002;57-74 Dekker, New York/Basel
19. Roberts L.J. II, Fessel J.P. The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation. Chem. Phys. Lipids. 128:2004;173-186
20. Basu S. Isoprostanes: novel bioactive products of lipid peroxidation. Free Radic. Res. 38:2004;105-122
21. Hodgson J.M., Croft K.D., Mori T.A., Burke V., Beilin L.J., Puddey I.B. Regular ingestion of tea does not inhibit in vivo lipid peroxidation in humans. J. Nutr. 132:2002;55-58
22. 2-isoprostanes and autoantibodies to oxidized LDL in healthy humans. Am. J. Clin. Nutr. 73:2001;1040-1044
23. 2-isoprostane formation in vivo. Free Radic. Biol. Med. 34:2003;795-799
24. Bailey D.M., Davies B., Young I.S. Intermittent hypoxic training: implications for lipid peroxidation induced by acute normoxic exercise in active men. Clin. Sci. (Lond.). 101:2001;465-475
25. Mastaloudis A., Leonard S.W., Traber M.G. Oxidative stress in athletes during extreme endurance exercise. Free Radic. Biol. Med. 31:2001;911-922
26. 2-isoprostanes. Eur. J. Appl. Physiol. 87:2002;38-42
27. Sacheck J.M., Milbury P.E., Cannon J.G., Roubenoff R., Blumberg J.B. Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. Free Radic. Biol. Med. 34:2003;1575-1588
28. Kirschvink N., Art T., Smith N., Lekeux P. Effect of exercise and COPD crisis on isoprostane concentration in plasma and bronchoalveolar lavage fluid in horses. Equine Vet. J. Suppl. 30:1999;88-91
29. Hinchcliff K.W., Reinhart G.A., DiSilvestro R., Reynolds A., Blostein-Fujii A., Swenson R.A. Oxidant stress in sled dogs subjected to repetitive endurance exercise. Am. J. Vet. Res. 61:2000;512-517
30. Long N.C., Suh J., Morrow J.D., Schiestl R.H., Murthy G.G., Brain J.D., Frei B. Ozone causes lipid peroxidation but little antioxidant depletion in exercising and non-exercising hamsters. J. Appl. Physiol. 91:2001;1694-1700
31. Hoffman-Goetz L., Quadrilatero J. Treadmill exercise in mice increases intestinal lymphocyte loss via apoptosis. Acta Physiol. Scand. 179:2003;289-297
32. Adamson G.E., Lazarus S.A., Mitchell A.E., Prior R.L., Cao G., Jacobs P.H., Kremers B.G., Hammerstone J.F., Rucker R.B., Ritter K.A., Schmitz H.H. HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity. J. Agric. Food Chem. 47:1999;4184-4188
33. 2-isoprostanes as markers of lipid peroxidation in rat brain mitochondria. Free Radic. Res. 36:2002;1-11
34. Jentzsch A.M., Bachmann H., Fürst P., Biesalski H.K. Improved analysis of malondialdehyde in human body fluids. Free Radic. Biol. Med. 20:1996;251-256
35. Epler K.S., Ziegler R.G., Craft N.E. Liquid chromatographic method for the determination of carotenoids, retinoids and tocopherols in human serum and in food. J. Chromatogr. 19:1993;37-48
36. Lykkesfeldt J., Loft S., Poulsen H.E. Determination of ascorbic acid and dehydroascorbic acid in plasma by HPLC with coulometric detection - are they reliable biomarkers of oxidative stress? Anal. Biochem. 229:1995;329-335
37. 4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. J. Neurochem. 72:1999;734-740
38. Jones B., Kenward M.G. Design and analysis of cross-over trials. 1989;Chapman and Hall, London, Glasgow/New York
39. Ursini F., Sevanian A. Postprandial oxidative stress. Biol. Chem. 383:2002;599-605
40. Natella F., Belelli F., Gentili V., Ursini F., Scaccini C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J. Agric. Food Chem. 50:2002;7720-7725
41. Plotnick G.D., Corretti M.C., Vogel R.A., Hesslink R., Wise J.A. Effect of supplemental phytonutrients on impairment of flow-mediated brachial artery vasoactivity after a single high-fat meal. J. Am. Coll. Cardiol. 41:2003;1744-1749
42. Aw T.Y. Determinants of intestinal detoxification of lipid hydroperoxides. Free Radic. Res. 28:1998;637-646
43. Halliwell B. Health benefits of eating chocolate? Nature. 426:2003;787
44. Mathur S., Devaraj S., Grundy S.M., Jialal I. Cocoa products decrease low density lipoprotein oxidative susceptibility, but do not affect biomarkers of inflammation in humans. J. Nutr. 132:2002;3663-3667
45. Rein D., Lototo S., Holt R.R., Keen C.L., Schmitz H.H., Fraga C.G. Epicatechin in human plasma: in vivo determination and plasma oxidation status. J. Nutr. 130:2000;2109S-2114S
46. Wang J.F., Schramm D.D., Holt R.R., Ensunsa J.L., Fraga C.G., Schmitz H.H., Keen C.L. Dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage. J. Nutr. 130:2000;2115S-2119S
47. Baba S., Osakabe N., Yasuda A., Natsume M., Takizawa T., Nakamura T., Terao J. Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radic. Res. 33:2000;635-641
48. Wan Y., Vinson J.A., Etherton T.D., Proch J., Lazarus S.A., Kris-Etherton P.M. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am. J. Clin. Nutr. 74:2001;596-602
49. Holt R.R., Lazarus S.A., Sullards M.C., Zhu Q.Y., Schramm D.D., Hammerstone J.F., Fraga C.G., Schmitz H.H., Keen C.L. Procyanidin dimer B2 [epicatechin-(4β-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am. J. Clin. Nutr. 76:2002;798-804
50. 2- isoprostane levels. Free Radic. Biol. Med. 28:2000;806-814
51. Young J.F., Dragstedt L.O., Harraldsdóttir J., Daneshvar B., Kall M.A., Loft S., Nilsson L., Nielsen S.E., Mayer B., Skibstedt L.H., Huynh-Ba T., Hermetter A., Sandström B. Green tea extract only effects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. Br. J. Nutr. 87:2002;343-355
52. Borg G. Psychological aspects of physical activities. Larson L.A. Fitness, health, and work capacity. 1974;141 Macmillan, New York