Tumor suppressor p53 binds with high affinity to CTG·CAG trinucleotide repeats and induces topological alterations in mismatched duplexes

Journal of Biological Chemistry

Volumn 280, Issue 52, 2005, Pages 42497-42507

  Walter, Korden ^a   Warnecke, Gabriele ^a   Bowater, Richard ^b   Deppert, Wolfgang ^a   Kim, Ella ^a,c  

^a LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TOPOLOGY;

CAG STRANDS; DNA LESIONS; TUMOR SUPPRESSORS;

TUMORS;

PROTEIN P53; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHROMATIN; CONTROLLED STUDY; DNA CONFORMATION; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; DNA STRUCTURE; DNA TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; TRINUCLEOTIDE REPEAT;

BASE PAIR MISMATCH; BINDING SITES; CELL LINE, TUMOR; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CLONING, MOLECULAR; DEOXYRIBONUCLEASES; DNA; DNA, SINGLE-STRANDED; GENES, P53; GENES, REPORTER; HUMANS; LUCIFERASES; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; TRANSFECTION; TRINUCLEOTIDE REPEATS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 30044440013     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507038200     Document Type: Article

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