Activation of p53 protein by telomeric (TTAGGG)n repeats

Nucleic Acids Research

Volumn 29, Issue 24, 2001, Pages 5207-5215

  Milyavsky, Michael ^a   Mimran, Avishai ^a   Senderovich, Shai ^a   Zurer, Irit ^a   Erez, Neta ^a   Shats, Igor ^a   Goldfinger, Naomi ^a   Cohen, Irun ^a   Rotter, Varda ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; APC PROTEIN; GUANINE; PROTEIN P53; THYMINE;

ARTICLE; CELL GROWTH; COLONY FORMATION; CONTROLLED STUDY; GENE ACTIVATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEOTIDE REPEAT; OLIGOMERIZATION; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; TELOMERE;

EID: 0035945252     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.24.5207     Document Type: Article

References (81)

1. For better or worse? Telomerase inhibition and cancer
2. The DNA structures at the ends of eukaryotic chromosomes
3. Mammalian telomeres end in a large duplex loop
4. Telomere length predicts replicative capacity of human fibroblasts
5. Extension of life-span by introduction of telomerase into normal human cells
6. Telomere loss: Mitotic clock or genetic time bomb?
7. TRF2 protects human telomeres from end-to-end fusions
8. Telomeres shorten during ageing of human fibroblasts
9. Telomere reduction in human colorectal carcinoma and with ageing
10. In vivo loss of telomeric repeats with age in humans
11. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
12. Escape from senescence in human diploid fibroblasts induced directly by mutant p53
13. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence
14. A role for both RB and p53 in the regulation of human cellular senescence
15. Cellular senescence and cancer
16. Telomeres. p53 and cellular senescence
17. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
18. p53-dependent cell cycle control: Response to genotoxic stress
19. p53, the cellular gatekeeper for growth and division
20. Regulation and function of the p53 tumor suppressor protein
21. Identification of p53 as a sequence-specific DNA-binding protein
22. The DNA binding regulatory domain of p53: See the C
23. Signaling to p53: Breaking the posttranslational modification code
24. The complexity of p53 modulation: Emerging patterns from divergent signals
25. The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia
26. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
27. Tumor suppressor p53 is a regulator of bc1-2 and bax gene expression in vitro and in vivo
28. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
29. A model for p53-induced apoptosis
30. p53AIP1, a potential mediator of p53-dependent apoptosis and its regulation by Ser-46-phosphorylated p53
31. Surfing the p53 network
32. Noxa, a BH3-only member of the Bc1-2 family and candidate mediator of p53-induced apoptosis
33. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer
34. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
35. High affinity insertion/deletion lesion binding by p53. Evidence for a role of the p53 central domain
36. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids
37. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
38. Enhanced phosphorylation of p53 by ATM in response to DNA damage
39. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
40. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
41. Covalent and noncovalent modifiers of the p53 protein
42. Telomerase in human development and cancer
43. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
44. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
45. Specific association of human telomerase activity with immortal cells and cancer
46. Telomere elongation in immortal human cells without detectable telomerase activity
47. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
48. Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions
49. Regulation of p53 stability
50. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
51. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
52. Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest
53. Functional reintroduction of human telomeres into mammalian cells
54. Stringent sequence requirements for the formation of human telomeres
55. Telomere directed fragmentation of mammalian chromosomes
56. Mdm2 promotes the rapid degradation of p53
57. Regulation of p53 stability by Mdm2
58. Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion
59. COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth and apoptosis
60. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
61. p21 is necessary for the p53-mediated G1 arrest in human cancer cells
62. Disruption of p53 in human cancer cells alters the responses to therapeutic agents
63. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
64. p21/p53, cellular growth control and genomic integrity
65. Telomere states and cell fates
66. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
67. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomer loss/DNA damage model of cell aging
68. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase
69. Regulation of p53 protein function through alterations in protein-folding pathways
70. Regulation of the specific DNA binding function of p53
71. Small peptides activate the latent sequence-specific DNA binding function of p53
72. Allosteric activation of latent p53 tetramers
73. DNA strand breaks - The DNA template alteration that triggers p53 dependent DNA damage response pathways
74. Recombination: A means to an end in human cells
75. Recombination in telomere-length maintenance
76. Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability
77. Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines
78. Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body
79. Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells
80. Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells
81. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit