메뉴 건너뛰기




Volumn 264, Issue 2, 1996, Pages 323-336

Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study

Author keywords

Conformation; Gene mutation; NMR and UV; Stability; Trinucleotide repeats

Indexed keywords

SINGLE STRANDED DNA; TRINUCLEOTIDE;

EID: 0030606224     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0643     Document Type: Article
Times cited : (87)

References (37)
  • 1
    • 0028045809 scopus 로고
    • Extracting thermodynamic data from equilibrium melting curves for oligonucleotide order-disorder transitions. In protocols for oligonucleotide conjugates
    • Breslauer, K. J. (1994). Extracting thermodynamic data from equilibrium melting curves for oligonucleotide order-disorder transitions. In Protocols for oligonucleotide conjugates. Methods Mol. Biol. 26, 347-372.
    • (1994) Methods Mol. Biol. , vol.26 , pp. 347-372
    • Breslauer, K.J.1
  • 3
    • 13344270899 scopus 로고    scopus 로고
    • Friedrich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion
    • Campuzano, V., Montemini, L., Koenig, M. & Pandolfo, M. (1996). Friedrich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science, 271, 1423-1427.
    • (1996) Science , vol.271 , pp. 1423-1427
    • Campuzano, V.1    Montemini, L.2    Koenig, M.3    Pandolfo, M.4
  • 5
    • 0028846524 scopus 로고
    • Anomalous rapid electrophoretic mobility of DNA containing triplet repeats associated with human disease genes
    • Chastain, P. D., II, Eichler, E. E., Kang, S., Nelson, D. L., Levene, S. D. & Sinden, R. R. (1995). Anomalous rapid electrophoretic mobility of DNA containing triplet repeats associated with human disease genes. Biochemistry, 34, 16125-16131.
    • (1995) Biochemistry , vol.34 , pp. 16125-16131
    • Chastain, P.D.1    Eichler, E.E.2    Kang, S.3    Nelson, D.L.4    Levene, S.D.5    Sinden, R.R.6
  • 8
    • 0028180778 scopus 로고
    • TCG triplet inversion in an antiparallel pur·pur·pyr DNA triplex. Conformational studies by NMR
    • Dittrich, K., Gu, J., Tinder, R., Hogan, M. & Gao, X. (1994). TCG triplet inversion in an antiparallel pur·pur·pyr DNA triplex. Conformational studies by NMR. Biochemisty, 33, 4111-4120.
    • (1994) Biochemisty , vol.33 , pp. 4111-4120
    • Dittrich, K.1    Gu, J.2    Tinder, R.3    Hogan, M.4    Gao, X.5
  • 10
    • 0004319414 scopus 로고
    • Longman Scientific & Technical, New York
    • Freeman, R. (1988). In A Handbook of NMR, pp. 97-100, Longman Scientific & Technical, New York.
    • (1988) A Handbook of NMR , pp. 97-100
    • Freeman, R.1
  • 11
    • 0028362201 scopus 로고
    • n nucleotide repeats form a stable tetrahelical structure
    • n nucleotide repeats form a stable tetrahelical structure. Proc. Natl Acad. Sci. USA, 91, 4950-4954.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 4950-4954
    • Fry, M.1    Loeb, L.2
  • 12
    • 0029053371 scopus 로고
    • Trinucleotide repeats that expand in human disease form hairpin structures in vitro
    • Gacy, A. M., Goeliner, G., Juranic, N., Macura, S. & McMurray, C. T. (1995). Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell, 81, 533-540.
    • (1995) Cell , vol.81 , pp. 533-540
    • Gacy, A.M.1    Goeliner, G.2    Juranic, N.3    Macura, S.4    McMurray, C.T.5
  • 13
    • 0028888242 scopus 로고
    • A new antiparallel duplex motif of DNA CCG repeats that is stabilized by extrahelical bases symmetrically located in the minor groove
    • Gao, X., Huang, X., Smith, G. K., Zheng, M. & Liu, H. (1995). A new antiparallel duplex motif of DNA CCG repeats that is stabilized by extrahelical bases symmetrically located in the minor groove. J. Am. Chem. Soc. 117, 8883-8884.
    • (1995) J. Am. Chem. Soc. , vol.117 , pp. 8883-8884
    • Gao, X.1    Huang, X.2    Smith, G.K.3    Zheng, M.4    Liu, H.5
  • 14
    • 0002578899 scopus 로고
    • Hairpins and heterochromatin: How triplet repeats may lead to disease
    • Hopkin, K. (1995). Hairpins and heterochromatin: how triplet repeats may lead to disease. J. NIH Res. 7, 45-48.
    • (1995) J. NIH Res. , vol.7 , pp. 45-48
    • Hopkin, K.1
  • 15
    • 0028807448 scopus 로고
    • Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes
    • Kang, S., Ohshima, K., Shimizu, M., Amirhaeri, S. & Wells, R. D. (1995a). Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes. J. Biol. Chem. 270, 27014-27021.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27014-27021
    • Kang, S.1    Ohshima, K.2    Shimizu, M.3    Amirhaeri, S.4    Wells, R.D.5
  • 16
    • 0029035379 scopus 로고
    • Expansion and deletion of CTG triplet repeats from human disease genes are determined by direction of replication
    • Kang, S., Jaworski, A., Ohshima, K. & Wells, R. D. (1995b). Expansion and deletion of CTG triplet repeats from human disease genes are determined by direction of replication. Nature Genet. 10, 213-218.
    • (1995) Nature Genet. , vol.10 , pp. 213-218
    • Kang, S.1    Jaworski, A.2    Ohshima, K.3    Wells, R.D.4
  • 17
    • 0029585993 scopus 로고
    • Solution structure of a DNA quadruplex containing the fragile X syndrome triplet repeat
    • Kettani, A., Kumar, A. & Patel, D. J. (1995). Solution structure of a DNA quadruplex containing the fragile X syndrome triplet repeat. J. Mol. Biol. 254, 638-656.
    • (1995) J. Mol. Biol. , vol.254 , pp. 638-656
    • Kettani, A.1    Kumar, A.2    Patel, D.J.3
  • 18
    • 0028010888 scopus 로고
    • Hhal methyltransferase flips its target base out of the DNA helix
    • Kimasauskas, S., Kumar, S., Robert, R. & Cheng, X. (1994), Hhal methyltransferase flips its target base out of the DNA helix. Cell, 76, 357-369.
    • (1994) Cell , vol.76 , pp. 357-369
    • Kimasauskas, S.1    Kumar, S.2    Robert, R.3    Cheng, X.4
  • 20
    • 0028805078 scopus 로고
    • 15 forms a heat-stable hairpin containing G(syn).·G(anti). Base-pairs
    • 15 forms a heat-stable hairpin containing G(syn).·G(anti). base-pairs. Biochemistry, 34, 12803-12811.
    • (1995) Biochemistry , vol.34 , pp. 12803-12811
    • Mitas, M.1    Yu, A.2    Dill, J.3    Haworth, I.S.4
  • 21
    • 0028860737 scopus 로고
    • n nucleotide repeats readily fold back to form unimolecular hairpin structure
    • n nucleotide repeats readily fold back to form unimolecular hairpin structure. J. Biol. Chem. 270, 28970-28977.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28970-28977
    • Nadel, Y.1    Weisman-Shomer, P.2    Fry, M.3
  • 22
    • 0020674698 scopus 로고
    • Base stacking and base-pairing contributions to helix stability
    • Petersheim, M. & Turner, D. H. (1983). Base stacking and base-pairing contributions to helix stability. Biochemistry, 22, 253-263.
    • (1983) Biochemistry , vol.22 , pp. 253-263
    • Petersheim, M.1    Turner, D.H.2
  • 23
    • 33845555707 scopus 로고
    • Exchangeable proton NMR without line distortion
    • Plateau, P. & Gueron, M. (1982). Exchangeable proton NMR without line distortion. J. Am. Chem. Soc. 104, 7310-7311.
    • (1982) J. Am. Chem. Soc. , vol.104 , pp. 7310-7311
    • Plateau, P.1    Gueron, M.2
  • 24
    • 0028781381 scopus 로고
    • DNA triplex: Solution structures, hydration sites, energetics, interactions, and function
    • Radhadrishnan, I. & Patel, D. J. (1995). DNA triplex: solution structures, hydration sites, energetics, interactions, and function. Biochemistry, 33, 11405-11416.
    • (1995) Biochemistry , vol.33 , pp. 11405-11416
    • Radhadrishnan, I.1    Patel, D.J.2
  • 25
    • 0029068629 scopus 로고
    • The crystal structure of HaeIII methyltranferase covalently complexed to DNA: An extrahelical cytosine and rearranged base-pairing
    • Reinisch, K. M., Chen, Lin, Verdine, G. L. & Lipscomb, W. N. (1995). The crystal structure of HaeIII methyltranferase covalently complexed to DNA: an extrahelical cytosine and rearranged base-pairing. Cell, 82, 143-153.
    • (1995) Cell , vol.82 , pp. 143-153
    • Reinisch, K.M.1    Chen2    Lin3    Verdine, G.L.4    Lipscomb, W.N.5
  • 26
  • 27
    • 0026489996 scopus 로고
    • Unusual DNA conformation at low pH revealed by NMR: Parallel-stranded DNA duplex with homo base-pairs
    • Robinson, H., van der Marel, G. A., van Boom, J. H. & Wang, A. H.-J. (1992). Unusual DNA conformation at low pH revealed by NMR: parallel-stranded DNA duplex with homo base-pairs. Biochemistry, 31, 10510-10517.
    • (1992) Biochemistry , vol.31 , pp. 10510-10517
    • Robinson, H.1    Van Der Marel, G.A.2    Van Boom, J.H.3    Wang, A.H.-J.4
  • 29
    • 0028864764 scopus 로고
    • DNA CTG triplet repeats involved in dynamic mutations of neurological related gene sequences form stable duplexes
    • Smith, G. K., Jie, J., Fox, G. E. & Gao, X. (1995). DNA CTG triplet repeats involved in dynamic mutations of neurological related gene sequences form stable duplexes. Nucl. Acids Res. 23, 4304-4311.
    • (1995) Nucl. Acids Res. , vol.23 , pp. 4304-4311
    • Smith, G.K.1    Jie, J.2    Fox, G.E.3    Gao, X.4
  • 30
    • 0028148342 scopus 로고
    • Hypermethylation of telomere-like foldbacks at codon 12 of the human c-Ha-ras gene and the trinucleotide repeat of the FMR-1 gene of fragile X
    • Smith, S. S., Laayoun, A., Lingeman, R. G., Baker, D. J. & Riley, J. (1994). Hypermethylation of telomere-like foldbacks at codon 12 of the human c-Ha-ras gene and the trinucleotide repeat of the FMR-1 gene of fragile X. J. Mol. Biol. 243, 143-151.
    • (1994) J. Mol. Biol. , vol.243 , pp. 143-151
    • Smith, S.S.1    Laayoun, A.2    Lingeman, R.G.3    Baker, D.J.4    Riley, J.5
  • 31
    • 2642628181 scopus 로고
    • A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants
    • States, D. L, Haberkorn, R. A. & Ruben, D. J. (1982). A two-dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants. J. Magn. Reson. 48, 286-292.
    • (1982) J. Magn. Reson. , vol.48 , pp. 286-292
    • States, D.L.1    Haberkorn, R.A.2    Ruben, D.J.3
  • 32
    • 0023664405 scopus 로고
    • Identification of I:A mismatch base-pairing structure in DNA
    • Uesugi, S., Oda, Y., Ikehara, M., Kawase, Y. & Ohtsuka, E. (1987). Identification of I:A mismatch base-pairing structure in DNA. J. Biol. Chem. 262, 6965-6968.
    • (1987) J. Biol. Chem. , vol.262 , pp. 6965-6968
    • Uesugi, S.1    Oda, Y.2    Ikehara, M.3    Kawase, Y.4    Ohtsuka, E.5
  • 33
    • 0028127370 scopus 로고
    • Solution structure of the d(TCGA). Duplex at acidic pH
    • Wang, Y. & Patel, D. J. (1994). Solution structure of the d(TCGA). duplex at acidic pH. J. Mol. Biol. 242, 508-526.
    • (1994) J. Mol. Biol. , vol.242 , pp. 508-526
    • Wang, Y.1    Patel, D.J.2
  • 34
    • 0030058075 scopus 로고    scopus 로고
    • Molecular basis of genetic instability of triplet repeats
    • Wells, R. D. (1996). Molecular basis of genetic instability of triplet repeats. J. Biol. Chem. 271, 2875-2878.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2875-2878
    • Wells, R.D.1
  • 35
    • 0027996828 scopus 로고
    • Dynamic mutations hit double figures
    • Willems, P. J. (1994). Dynamic mutations hit double figures. Nature Genet. 8, 212-214.
    • (1994) Nature Genet. , vol.8 , pp. 212-214
    • Willems, P.J.1
  • 37
    • 0029099357 scopus 로고
    • Single-stranded DNA binding proteins isolated from mouse brain recognize specific trinucleotide repeat sequences in vitro
    • Yano-Yanagisawa, H., Li, Y., Wang, H. & Kohwi, Y. (1995). Single-stranded DNA binding proteins isolated from mouse brain recognize specific trinucleotide repeat sequences in vitro. Nucl. Acids Res. 23, 2654-2660.
    • (1995) Nucl. Acids Res. , vol.23 , pp. 2654-2660
    • Yano-Yanagisawa, H.1    Li, Y.2    Wang, H.3    Kohwi, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.