Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases

Nucleic Acids Research

Volumn 30, Issue 22, 2002, Pages 4910-4917

  Hou, Ming Hon ^a   Robinson, Howard ^b,c   Gao, Yi Gui ^b   Wang, Andrew H J ^a,b,d  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CRUCIFORM DNA; CYTOSINE; DACTINOMYCIN; DNA TOPOISOMERASE; GUANINE; THYMINE; TRINUCLEOTIDE;

BASE MISPAIRING; BASE PAIRING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA DENATURATION; DNA FLANKING REGION; DNA HELIX; DRUG DNA BINDING; DRUG STRUCTURE; GEL ELECTROPHORESIS; GEL MOBILITY SHIFT ASSAY; GENE REPLICATION; GENETIC TRANSCRIPTION; NEUROLOGIC DISEASE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVIEW; TRINUCLEOTIDE REPEAT;

EID: 18744395179     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf619     Document Type: Review

References (29)

1. Sobell, H.M. and Jain, S.C. (1972) Stereochemistry of actinomycin binding to DNA. II. Detailed molecular model of actinomycin-DNA complex and its implications. J. Mol. Biol., 68, 21-34.
2. Kamitori, S. and Takusagawa, F. (1992) Crystal structure of the 2:1 complex between d(GAAGCTTC) and the anticancer drug actinomycin D. J. Mol. Biol., 225, 445-456.
3. Hurwitz, J., Furth, J.J., Malamy, M. and Alexander, M. (1962) The role of deoxyribonucleic acid in ribonucleic acid synthesis. III: The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin. Proc. Natl Acad. Sci. USA, 48, 1222-1230.
4. Aivasashvilli, V.A. and Beabealashvilli, R.S. (1983) Sequence-specific inhibition of RNA elongation by actinomycin D. FEBS Lett., 160, 124-128.
5. Chen, F.M. (1988) Kinetic and equilibrium binding studies of actinomycin D with some d(TGCA)-containing dodecamers. Biochemistry, 27, 1843-1848.
6. Margolis, R.L., O'Hearn, E., Rosenblatt, A., Willour, V., Holmes, S.E., Franz, M.L., Callahan, C., Hwang, H.S., Troncoso, J.C. and Ross, C.A. (2001) A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion. Ann. Neurol., 50, 373-380.
7. Seznec, H., Agbulut, O., Sergeant, N., Savouret, C., Ghestem, A., Tabti, N., Willer, J.C., Ourth, L., Duros, C., Brisson, E. et al. (2001) Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities. Hum. Mol. Genet., 10, 2717-2726.
8. Paulson, H.L. and Fischbeck, K.H. (1996) Trinucleotide repeats in neurogenetic disorders. Annu. Rev. Neurosci., 19, 79-107.
9. Warren, S.T. and Ashley, C.T., Jr (1995) Triplet repeat expansion mutations: the example of fragile X syndrome. Annu. Rev. Neurosci., 18, 77-99.
10. Pluciennik, A., Iyer, R.R., Parniewski, P. and Wells, R.D. (2000) Tandem duplication: a novel type of triplet repeats instability. J. Biol. Chem., 275, 28386-28397.
11. McMurray, C.T. (1999) DNA secondary structure: a common and causative factor for expansion in human disease. Proc. Natl Acad. Sci. USA, 96, 1823-1825.
12. Kovtun, I.V. and McMurray, C.T. (2001) Trinucleotide expansion in haploid germ cells by gap repair. Nature Genet., 27, 407-411.
13. Petruska, J., Arnheim, N. and Goodman, M.F. (1996) Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. Nucleic Acids Res., 24, 1992-1998.
14. Jakupciak, J.P. and Wells, R.D. (1999) Genetic instabilities in (CTG.CAG) repeats occur by recombination. J. Biol. Chem., 274, 23468-23479.
15. Bowater, R.P. and Wells, R.D. (2001) The intrinsically unstable life of DNA triplet repeats associated with human hereditary disorders. Prog. Nucleic Acid Res. Mol. Biol., 66, 159-202.
16. n triplet sequence as determined by NMR analysis. J. Am. Chem. Soc., 118, 8791-8801.
17. Liu, C. and Chen, F.M. (1996) Actinomycin D binds strongly and dissociates slowly at the dGpdC site with flanking T/T mismatches. Biochemistry, 35, 16346-16353.
18. Hou, M.H., Lin, S.B., Yuann, J.M., Lin, W.C., Wang, A.H.-J and Kan, L.S. (2001) Effects of polyamines on the thermal stability and formation kinetics of DNA duplexes with abnormal structure. Nucleic Acids Res., 29, 5121-5128.
19. Wang, A.H.-J. and Gao, Y.G. (1990) Crystallization of oligonucleotides and their complexes with antitumor drugs. Methods, 1, 91-99.
20. Walsh, M.A., Evans, G., Sanishvili, R., Dementieva, I. and Joachimiak, A. (1999) MAD data collection-current trends. Acta Crystallogr., D55, 1726-1732.
21. Gao, Y.G., Robinson, H., Sanishvili, R., Joachimiak, A. and Wang, A.H.-J. (1999) Structure and recognition of sheared tandem G x A base pairs associated with human centromere DNA sequence at atomic resolution. Biochemistry, 38, 16452-16460
22. Otwinowski, Z. and Minor, W. (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol., 276, 307-326.
23. Brunger, A.T., Adams, P.D., Clore, G.M., DeLano, W.L., Gros, P., Grosse-Kunstleve, R.W., Jiang, J.S., Kuszewski, J., Nilges, M., Pannu, N.S. et al. (1998) Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr., D54, 905-921.
24. Parkinson, G., Vojtechovsky, J., Clowney, L., Brunger, A.T. and Berman, H.M. (1996) New parameters for the refinement of nucleic acid containing structures. Acta Crystallogr, D52, 57-64.
25. Lavery, R. and Sklenar, H. (1988) The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids. J. Biomol. Struct. Dyn., 6, 63-91.
26. Chen, H., Liu, X. and Patel, D.J. (1996) DNA bending and unwinding associated with actinomycin D antibiotics bound to partially overlapping sites on DNA. J. Mol. Biol., 258, 457-479.
27. Robinson, H., Gao, Y.G., Yang, X., Sanishvili, R., Joachimiak, A. and Wang, A.H.-J. (2001) Crystallographic analysis of a novel complex of actinomycin D bound to the DNA decamer CGATCGATCG. Biochemistry, 40, 5587-5592.
28. Chou, S.H., Chin, K.H. and Chen, F.M. (2002) Looped out and perpendicular: deformation of Watson-Crick base pair associated with actinomycin D binding. Proc. Natl Acad. Sci. USA, 99, 6625-6630.
29. Petruska, J., Hartenstine, M.J. and Goodman, M.F. (1998) Analysis of strand slippage in DNA polymerase expansions of CAG/CTG triplet repeats associated with neurodegenerative disease. J. Biol. Chem., 273, 5204-5210.