Scanning force microscopy of the complexes of p53 core domain with supercoiled DNA

Journal of Molecular Biology

Volumn 299, Issue 3, 2000, Pages 585-592

  Jett, Stephen D ^a   Cherny, Dmitry I ^a,b   Subramaniam, Vinod ^a   Jovin, Thomas M ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

Cruciform; DNA protein complexes; p53; Scanning force microscopy; Supercoiled DNA

Indexed keywords

DNA; PROTEIN P53;

ARTICLE; COMPLEX FORMATION; CONSENSUS SEQUENCE; DNA SUPERCOILING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN DOMAIN; SCANNING FORCE MICROSCOPY; TUMOR SUPPRESSOR GENE;

MICA;

EID: 0034625323     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3759     Document Type: Article

References (48)

1. Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA
2. Supercoiling in closed circular DNA: Dependence upon ion type and concentration
3. Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA
4. The twist, writhe and overall shape of supercoiled DNA change during counterion-induced transition from a loosely to a tightly interwound superhelix. Possible implications for DNA structure in vivo
5. Adsorption of DNA to mica, silylated mice, and minerals: Characterization by atomic-force microscopy
6. Circular DNA molecules imaged in air by scanning force microscopy
7. DNA bending due to specific p53 and p53 core domain-DNA interactions visualized by electron microscopy
8. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
9. High-resolution structure of the oligomerization domain of p53 by multidimensional NMR
10. DNA bending, flexibility, and helical repeat by cyclization kinetics
11. Mechanisms of p53-mediated apoptosis
12. Definition of a consensus binding site for p53
13. The p53 protein is an unusually shaped tetramer that binds directly to DNA
14. A transcriptionally active DNA-binding site for human p53 protein complexes
15. Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants
16. Identification of p53 as a sequence-specific DNA-binding protein
17. Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53
18. p53: Puzzle and paradigm
19. Human p53 binds Holliday junctions strongly and facilitates their cleavage
20. p53, the cellular gatekeeper for growth and division
21. Visualization of supercoiled DNA with atomic force microscopy in situ
22. Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain
23. How p53 binds DNA as a tetramer
24. Multisite phosphorylation and the integration of stress signals at p53
25. DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53
26. Architectural
27. Accommodation m the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element
28. p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting
29. Local supercoil-stabilized DNA structures
30. Tumor suppressor protein p53 binds preferentially to supercoiled DNA
31. Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments
32. The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots
33. Scanning force microscopy of DNA deposited onto mica: Equilibration versus kinetic trapping studied by statistical polymer chain analysis
34. The effect of ionic conditions on DNA helical repeat, effective diameter and free energy of super-coiling
35. Deposition of supercoiled DNA on mica for scanning force microscopy imaging
36. Structure and dynamics of supercoil-stabilized DNA cruciforms
37. Structural aspects of the p53 protein in relation to gene evolution: A second look
38. p53 oligomerization and DNA looping are linked with transcriptional activation
39. Atomic force microscopy of supercoiled DNA structure on mica
40. Atomic force microscopy of DNA on mica and chemically modified mica. Scanning Microscopy
41. p53 tagged sites from human genomic DNA
42. Substrate preparation for reliable imaging of DNA molecules with the scanning force microscope
43. Conformational and thermodynamic properties of super-coiled DNA
44. p53 domains: Identification and characterization of two autonomous DNA-binding regions
45. Interaction of p53 with its consensus DNA-binding site
46. Monovalent cations differ in their effects on transcription initiation from a sigma-70 promoter of Escherichia coli
47. The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding