Dysfunction of mitochondrial complex I and the proteasome: Interactions between two biochemical deficits in a cellular model of Parkinson's disease

Journal of Neurochemistry

Volumn 86, Issue 5, 2003, Pages 1297-1307

  Höglinger, Günter U ^a   Carrard, Géraldine ^b   Michel, Patrick P ^a   Medja, Fadia ^a   Lombès, Anne ^a   Ruberg, Merle ^a   Friguet, Bertrand ^b   Hirsch, Etienne C ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

6 hydroxydopamine; Mitochondrial complex I; MPP+; Parkinson's disease; Proteasome; Rotenone

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 6 HYDROXYDOPA; ADENOSINE TRIPHOSPHATE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; EPOXOMICIN; FREE RADICAL; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID; PROTEASOME; PROTEASOME INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; ENERGY YIELD; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; MESENCEPHALON; MODEL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SUBSTANTIA NIGRA;

ANIMALIA;

EID: 0041430614     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01952.x     Document Type: Article

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