Antibody-mediated signalling through PD-1 costimulates T cells and enhances CD28-dependent proliferation

European Journal of Immunology

Volumn 35, Issue 12, 2005, Pages 3545-3560

  del Rio, María Luisa ^a   Penuelas Rivas, Giovanna ^a   Dominguez Perles, Raul ^a   Ramirez, Pablo ^a   Parrilla, Pascual ^a   Rodriguez Barbosa, Jose Igancio ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

Author keywords

Costimulation; Programmed death 1 (PD 1, CD279); T cell proliferation

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD28 ANTIGEN; CD3 ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1H10; MONOCLONAL ANTIBODY 4F10; MONOCLONAL ANTIBODY PD 1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; IMMUNOLOGICAL ADJUVANT; MEMBRANE ANTIGEN; PDCD1 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL INTERACTION; FEMALE; GENE EXPRESSION REGULATION; ISOGRAFT; LYMPHOCYTE PROLIFERATION; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL PROLIFERATION; CHO CELL; CRICETULUS; GENETICS; HAMSTER; HYBRIDOMA; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; HYBRIDOMAS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 29744440889     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535232     Document Type: Article

References (50)

1. Brunner, M. C., Chambers, C. A., Chan, F. K., Hanke, J., Winoto, A. and Allison, J. P., CTLA-4-mediated inhibition of early events of T cell proliferation. J. Immunol. 1999. 162: 5813-5820.
2. Lenschow, D. J., Walunas, T. L. and Bluestone, J. A., CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 1996. 14: 233-258.
3. Ishida, Y., Agata, Y., Shibahara, K. and Honjo, T., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992. 11: 3887-3895.
4. Ansari, M. J., Salama, A. D., Chitnis, T., Smith, R. N., Yagita, H., Akiba, H., Yamazaki, T. et al., The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 2003. 198: 63-69.
5. Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J., Akiba, H., Tushima, F., Azuma, M. et al., Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J. Exp. Med. 2003. 198: 71-78.
6. Blazar, B. R., Carreno, B. M., Panoskaltsis-Mortari, A., Carter, L., Iwai, Y., Yagita, H., Nishimura, H. and Taylor, P. A., Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J. Immunol. 2003. 171: 1272-1277.
7. Tsushima, F., Iwai, H., Otsuki, N., Abe, M., Hirose, S., Yamazaki, T., Akiba, H. et al., Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur. J. Immunol. 2003. 33: 2773-2782.
8. Iwai, Y., Terawaki, S., Ikegawa, M., Okazaki, T. and Honjo, T., PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 2003. 198: 39-50.
9. Nishimura, H. and Honjo, T., PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 2001. 22: 265-268.
10. Leibson, P. J., The regulation of lymphocyte activation by inhibitory receptors. Curr. Opin. Immunol. 2004. 16: 328-336.
11. Khoury, S. J. and Sayegh, M. H., The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity 2004. 20: 529-538.
12. Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubata, T., Yagita, H. and Honjo, T., Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 1996. 8: 765-772.
13. Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T., Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999. 11: 141-151.
14. Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S. et al., Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 2001. 291: 319-322.
15. Okazaki, T., Tanaka, Y., Nishio, R., Mitsuiye, T., Mizoguchi, A., Wang, J., Ishida, M. et al., Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat. Med. 2003. 9: 1477-1483.
16. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T. et al., Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 2002. 169: 5538-5545.
17. Ishida, M., Iwai, Y., Tanaka, Y., Okazaki, T., Freeman, G. J., Minato, N. and Honjo, T., Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol. Lett. 2002. 84: 57-62.
18. Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T. and Honjo, T., PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. USA 2001. 98: 13866-13871.
19. Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J. et al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000. 192: 1027-1034.
20. Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y. et al., PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2001. 2: 261-268.
21. Carter, L., Fouser, L., Jussif, J., Fitz, L., Deng, B., Wood, C., Collins, M. et al., PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J. Immunol. 2002. 32: 634-643.
22. + T cell activation and cytolysis. Eur. J. Immunol. 2003. 33: 3117-3126.
23. Mazanet, M. M. and Hughes, C. C., B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol. 2002. 169: 3581-3588.
24. Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A. et al., B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 2001. 193: 839-846.
25. Dong, H., Zhu, G., Tamada, K. and Chen, L., B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 1999. 5: 1365-1369.
26. Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T. and Chen, L., Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. 2003. 197: 1083-1091.
27. + T cells independent of the PD-1 receptor. J. Exp. Med. 2003. 198: 31-38.
28. Greenwald, R. J., Freeman, G. J. and Sharpe, A. H., The B7 family revisited. Annu. Rev. Immunol. 2005. 23: 515-548.
29. Carreno, B. M. and Collins, M., BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003. 24: 524-527.
30. Benjamin, D. C., Berzofsky, J. A., East, I. J., Gurd, F. R., Hannum, C., Leach, S. J., Margoliash, E. et al., The antigenic structure of proteins: a reappraisal. Annu. Rev. Immunol. 1984. 2: 67-101.
31. Tamura, H., Dong, H., Zhu, G., Sica, G. L., Flies, D. B., Tamada, K. and Chen, L., B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001. 97: 1809-1816.
32. + T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2. J. Immunol. 1998. 160: 5007-5017.
33. Shin, T., Yoshimura, K., Shin, T., Crafton, E. B., Tsuchiya, H., Housseau, F., Koseki, H. et al., In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J. Exp. Med. 2005. 201: 1531-1541.
34. Carreno, B. M. and Collins, M., The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 2002. 20: 29-53.
35. Greenwald, R. J., Latchman, Y. E. and Sharpe, A. H., Negative co-receptors on lymphocytes. Curr. Opin. Immunol. 2002. 14: 391-396.
36. Ozkaynak, E., Wang, L., Goodearl, A., McDonald, K., Qin, S., O'Keefe, T., Duong, T. et al., Programmed death-1 targeting can promote allograft survival. J. Immunol. 2002. 169: 6546-6553.
37. Latchman, Y. E., Liang, S. C., Wu, Y., Chernova, T., Sobel, R. A., Klemm, M., Kuchroo, V. K. et al., PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl. Acad. Sci. USA 2004. 101: 10691-10696.
38. Subudhi, S. K., Zhou, P., Yerian, L. M., Chin, R. K., Lo, J. C., Anders, R. A., Sun, Y. et al., Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest. 2004. 113: 694-700.
39. Ito, T., Ueno, T., Clarkson, M. R., Yuan, X., Jurewicz, M. M., Yagita, H., Azuma, M. et al., Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J. Immunol. 2005. 174: 6648-6656.
40. Brown, J. A., Dorfman, D. M., Ma, F. R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A. and Freeman, G. J., Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 2003. 170: 1257-1266.
41. Oflazoglu, E., Swart, D. A., Anders-Bartholo, P., Jessup, H. K., Norment, A. M., Lawrence, W. A., Brasel, K. et al., Paradoxical role of programmed death-1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo. Eur. J. Immunol. 2004. 34: 3326-3336.
42. + T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection. J. Exp. Med. 1999. 190: 367-374.
43. Gan, X. and Huang, L., Cationic liposome-mediated gene transfer. Gene Ther. 1995. 2: 710-722.
44. Davis, W. C., Zuckermann, F. A., Hamilton, M. J., Barbosa, J. I., Saalmuller, A., Binns, R. M. and Licence, S. T., Analysis of monoclonal antibodies that recognize gamma delta T/null cells. Vet. Immunol. Immunopathol. 1998. 60: 305-316.
45. Kremmer, E., Kranz, B. R., Hille, A., Klein, K., Eulitz, M., Hoffmann-Fezer, G., Feiden, W. et al., Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigens 2A (EBNA2A) and 2B (EBNA2B). Virology 1995. 208: 336-342.
46. Rodriguez-Barbosa, J. I., Gutierrez Martin, C. B., Tascon, R. I., Suarez, J. and Rodriguez Ferri, E. F., Evidence obtained with monoclonal antibodies that O antigen is the major antigen responsible for the cross-reactivities between serotypes 4 and 7 of Actinobacillus (Haemophilus) pleuropneumoniae. Clin. Diagn. Lab. Immunol. 1995. 2: 563-568.
47. Kearney, J. F., Radbruch, A., Liesegang, B. and Rajewsky, K., A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 1979. 123: 1548-1550.
48. Unkeless, J. C., Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 1979. 150: 580-596.
49. Suchin, E. J., Langmuir, P. B., Palmer, E., Sayegh, M. H., Wells, A. D. and Turka, L. A., Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J. Immunol. 2001. 166: 973-981.
50. Lyons, A. B., Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J. Immunol. Methods 2000. 243: 147-154.