Paradoxical role of programmed death-1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo

European Journal of Immunology

Volumn 34, Issue 12, 2004, Pages 3326-3336

  Oflazoglu, Ezogelin ^a   Swart, David A ^a   Anders Bartholo, Penny ^a   Jessup, Heidi K ^a   Norment, Anne M ^a   Lawrence, William A ^a   Brasel, Kenneth ^a   Tocker, Joel E ^a   Horan, Tom ^a   Welcher, Andrew A ^a   Fitzpatrick, David R ^a  

^a AMGEN INC   (United States)

Author keywords

Dendritic cells; PD 1; PD L2; Regulatory T cells; Th2 cells

Indexed keywords

CD28 ANTIGEN; CYTOKINE; FC RECEPTOR; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 5; LIGAND; PROGRAMMED DEATH 1; PROGRAMMED DEATH 1 LIGAND 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL COUNT; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EOSINOPHIL; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREGULATION; IN VITRO STUDY; LUNG LAVAGE; LYMPH NODE; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; T LYMPHOCYTE; TH2 CELL;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; ASTHMA; CYTOKINES; DENDRITIC CELLS; FEMALE; IMMUNOGLOBULIN E; LUNG; LYMPH NODES; MEMBRANE GLYCOPROTEINS; MICE; PEPTIDES; TH2 CELLS;

EID: 19944374074     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425197     Document Type: Article

References (38)

1. Greenwald, R. J., Latchman, Y. E. and Sharpe, A. H., Negative co-receptors on lymphocytes. Curr. Opin. Immunol 2002. 14: 391-396.
2. Chambers, C. A., Kuhns, M. S., Egan, J. G. and Allison, J. P., CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol 2001. 19: 565-594.
3. Salomon, B. and Bluestone, J. A., Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol 2001. 19: 225-252.
4. Coyle, A. J. and Guiterrez-Ramos, J. C., The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol 2001. 2: 203-209.
5. Frauwirth, K. A. and Thompson, C. B., Activation and inhibition of lymphocytes by costimulation. J. Clin. Invest 2002. 109: 295-299.
6. Sharpe, A. H. and Freeman, G. J., The B7-CD28 superfamily. Nat. Rev. Immunol 2002. 2: 116-126.
7. Ishida, Y., Agata, Y., Shibara, K. and Honjo, T., Induced expression of PD-1, a novel immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992. 11: 3887-3895.
8. Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubata, T., Yagita, H. and Honjo, T., Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol 1996. 8: 765-772.
9. Shinohara, T., Taniwaki, M., Ishida, Y., Kawaichi, M. and Honjo, T., Structure and chromosomal localization of the human PD-1 gene (PDCD1). Genomics 1994. 23: 704-706.
10. Vivier, E. and Daeron, M., Immunoreceptor tyrosine-based inhibition motifs. Immunol. Today 1997. 18: 286-291.
11. -) thymocytes. Int. Immunol. 1996. 8: 773-780.
12. Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T., Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999. 11: 141-151.
13. Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N. and Honjo, T., Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 2001. 291: 319-322.
14. Lechner, O., Lauber, J., Franzke, A., Sarukhan, A., von Boehmer, H. and Buer, J., Fingerprint of anergic T cells. Curr. Biol 2001. 11: 587-595.
15. Gavin, M. A., Clarke, S. R., Negreu, E., Gallegos, A. and Rudensky, A., Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat. Immunol 2002 3: 33-41.
16. Dong, H., Zhu, G., Tamada, K. and Chen, L., B7-H1, a third member of the B7 family, co-stimulates T cell proliferation and interleukin-10 secretion. Nat. Med. 1999. 5: 1365-1369.
17. Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000. 192: 1027-1034.
18. Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, C., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., Greenfield, E. A., Bourque, K., Boussiotis, V. A., Carter, L. L., Carreno, B. M., Malenkovich, N., Nishimura, H., Okazaki, T., Honjo, T., Sharpe, A. H. and Freeman, G. J., PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2001. 2: 261-268.
19. Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M. and Tsuchiya, H., B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 2001. 193: 839-846.
20. Tamura, H., Dong, H., Zhu, G., Sica, G. L., Flies, D. B., Tamada, K. and Chen, L., B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 2001. 97: 1809-1816.
21. Loke, P. and Allison, J. P., PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc. Natl. Acad. Sci. USA 2003. 100: 5336-5341.
22. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D. M., Okumura, K., Azuma, M. and Yagita, H., Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 2002 169: 5538-5545.
23. Umetsu, D., McIntire, J. J., Akbari, O., Macaubas, C. and DeKruyff, R. D., Asthma: an epidemic of dysregulated immunity. Nat. Immunol. 2002 3: 715-720.
24. Van Rijt, L. S. and Lambrecht, B. N., Role of dendritic cells and Th2 lymphocytes in asthma: lessons from eosinophilic airway inflammation in the mouse. Microsc. Res. Tech. 2001. 53: 256-272.
25. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol. 1994. 10: 587-593.
26. Cohn, L., Homer, R. J., MacLeod, H., Mohrs, M., Brombacher, F. and Bottomly, K., Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J. Immunol. 1999. 162: 6178-6183.
27. Lambrecht, B. N. and Hammad, H., Taking our breath away: dendritic cells in pathogenesis of asthma. Nat. Rev. Immunol. 2003. 3: 994-1003.
28. Akbari, O., Freeman, G. J., Meyer, E. H., Greenfield, E. A., Chang, T. T., Sharpe, A. H., Berry, G., DeKruyff, R. H. and Umetsu, D. T., Antigen specific regulatory T cells develop via ICOS-ICOS-ligand pathway and inhibit allergen induced airway hyperreactivity. Nat. Med. 2002 8: 1024-1032.
29. Coyle, A. J., Le Gros, G., Bertrand, C., Tsuyuki, S., Heusser, C. H., Kopf, M. and Anderson, G. P., Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am. J. Respir. Cell Mol. Biol. 1995. 13: 54-59.
30. Foster, P. S., Hogan, S. P., Ramsay, A. J., Matthaei, K. I. and Young, I. G., Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 1996. 183: 195-201.
31. Grunig, G., Warnock, M., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M. and Corry, D. B., Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998. 282: 2261-2263.
32. Townsend, M. J., Fallon, P. G., Matthews, D. J., Smith, P., Jolin, H. E. and McKenzie, A. N., IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity. 2000. 13: 573-583.
33. George, T. C., Bilsborough, J., Viney, J. L. and Norment, A. M., High antigen dose and activated dendritic cells enable Th cells to escape regulatory T cell-mediated suppression in vitro. Eur. J. Immunol. 2003. 33: 502-511.
34. high regulatory cells in human peripheral blood. J. Immunol 2001. 167: 1245-1253.
35. Liu, X., Gao, J. X., Wen, J., Yin, L., Li, O., Zuo, T., Gajewski, T. F., Fu, Y. X., Zheng, P. and Liu, Y., B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med. 2003. 197: 1721-1730.
36. Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T. and Chen, L., Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. 2003. 197: 1083-1091.
37. + T cells independent of the PD-1 receptor. J. Exp. Med. 2003. 198: 31-38.
38. DeClerck, Y. A., Yean, T. D., Lu, H. S., Ting, J. and Langley, K. E., Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2. J. Biol. Chem 1991. 266: 3893-3899.