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Volumn 65, Issue 4, 2005, Pages 291-300

Small molecule melanin-concentrating hormone receptor 1 (MCH1R) antagonists as anxiolytic and antidepressive agents

Author keywords

Anxiety; Depression; Melanin concentrating hormone

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ATC 0065; ATC 0175; DOPAMINE; DOPAMINE UPTAKE INHIBITOR; FLUOXETINE; GLUTAMIC ACID; HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; MIRTAZAPINE; MONOAMINE OXIDASE INHIBITOR; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; NEUROPEPTIDE RECEPTOR; NEUROTRANSMITTER; NORADRENALIN; NORADRENALIN UPTAKE INHIBITOR; PAROXETINE; QUINAZOLINE DERIVATIVE; RECEPTOR SUBTYPE; SB 568849; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SIBUTRAMINE; SNAP 7941; SNAP 94847; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 29544433086     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.20030     Document Type: Review
Times cited : (10)

References (92)
  • 2
    • 29544434422 scopus 로고    scopus 로고
    • Amgen. 2005. Available on line at www.amgen.com/science/pipe_AMG076.html.
    • (2005)
  • 4
    • 4344632536 scopus 로고    scopus 로고
    • Psychotropic drugs in the treatment of obesity. What promise?
    • Appolinario JC, Bueno JR, Coutinho W. 2004. Psychotropic drugs in the treatment of obesity. What promise? CNS Drugs 18:629-651.
    • (2004) CNS Drugs , vol.18 , pp. 629-651
    • Appolinario, J.C.1    Bueno, J.R.2    Coutinho, W.3
  • 7
    • 0037150078 scopus 로고    scopus 로고
    • Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1
    • Bednarek MA, Hreniuk DL, Tan C, Palyha OC, MacNeil DJ, Van der Ploeg LHY, Howard AD, Feighner SD. 2002. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry 41:6383-6390.
    • (2002) Biochemistry , vol.41 , pp. 6383-6390
    • Bednarek, M.A.1    Hreniuk, D.L.2    Tan, C.3    Palyha, O.C.4    MacNeil, D.J.5    Van Der Ploeg, L.H.Y.6    Howard, A.D.7    Feighner, S.D.8
  • 9
    • 0029048874 scopus 로고
    • Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat
    • Bluet-Pajot M-T, Presse F, Voko Z, Hoeger C, Mounier F, Epelbaum J, Nahon J-L. 1995. Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat. J Neuroendocrinol 7:297-303.
    • (1995) J Neuroendocrinol , vol.7 , pp. 297-303
    • Bluet-Pajot, M.-T.1    Presse, F.2    Voko, Z.3    Hoeger, C.4    Mounier, F.5    Epelbaum, J.6    Nahon, J.-L.7
  • 12
    • 0036053186 scopus 로고    scopus 로고
    • Do animal models of anxiety predict anxiolytic-like effects of antidepressants?
    • Borsini F, Podhorna J, Marazziti D. 2002. Do animal models of anxiety predict anxiolytic-like effects of antidepressants? Psychopharmacology 163:121-141.
    • (2002) Psychopharmacology , vol.163 , pp. 121-141
    • Borsini, F.1    Podhorna, J.2    Marazziti, D.3
  • 18
    • 0037869116 scopus 로고    scopus 로고
    • Prospects for obesity treatment: MCH receptor antagonists
    • Collins CA, Kym PR. 2003. Prospects for obesity treatment: MCH receptor antagonists. Curr Opin Investig Drugs 4:386-394.
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 386-394
    • Collins, C.A.1    Kym, P.R.2
  • 19
    • 3042686679 scopus 로고    scopus 로고
    • Response, partial response, and nonresponse in primary care treatment of depression
    • Corey-Lisle PK, Nash R, Stang P, Swindle R. 2004. Response, partial response, and nonresponse in primary care treatment of depression. Arch Intern Med 164:1197-1204.
    • (2004) Arch Intern Med , vol.164 , pp. 1197-1204
    • Corey-Lisle, P.K.1    Nash, R.2    Stang, P.3    Swindle, R.4
  • 20
    • 0036797774 scopus 로고    scopus 로고
    • Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats
    • Della-Znana O, Presse F, Ortola C, Dubault J, Nahon JL, Levens N. 2002. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Int J Obesity 26:1289-1295.
    • (2002) Int J Obesity , vol.26 , pp. 1289-1295
    • Della-Znana, O.1    Presse, F.2    Ortola, C.3    Dubault, J.4    Nahon, J.L.5    Levens, N.6
  • 21
    • 0029019234 scopus 로고
    • Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists
    • Detke MJ, Wieland S, Lucki I. 1995. Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists. Psychopharmacology (Berl) 119:47-54.
    • (1995) Psychopharmacology (Berl) , vol.119 , pp. 47-54
    • Detke, M.J.1    Wieland, S.2    Lucki, I.3
  • 23
    • 0035118307 scopus 로고    scopus 로고
    • Quality of life and psychosocial adjustment in patients after Roux-en-Y gastric bypass: A brief report
    • Dymek MP, le Grange D, Neven K, Alverdy J. 2001. Quality of life and psychosocial adjustment in patients after Roux-en-Y gastric bypass: a brief report. Obes Surg 11:32-39.
    • (2001) Obes Surg , vol.11 , pp. 32-39
    • Dymek, M.P.1    Le Grange, D.2    Neven, K.3    Alverdy, J.4
  • 26
    • 29544439638 scopus 로고    scopus 로고
    • GlaxoSmithKline. 2005. Available on line at www.gsk.com/financial/ product_pipe-line.html.
    • (2005)
  • 27
    • 0029670663 scopus 로고    scopus 로고
    • Behavioral effects of α-MSH and MCH after central administration in the female rat
    • Gonzalez MI, Vaziri S, Wilson CA. 1996. Behavioral effects of α-MSH and MCH after central administration in the female rat. Peptides 17:171-177.
    • (1996) Peptides , vol.17 , pp. 171-177
    • Gonzalez, M.I.1    Vaziri, S.2    Wilson, C.A.3
  • 28
    • 0031857410 scopus 로고    scopus 로고
    • Behavioral effects of neuropeptide E-I (NEI) in the female rat: Interactions with α-MSH, MCH and dopamine
    • Gonzalez MI, Baker BI, Hole DR, Wilson CA. 1998. Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with α-MSH, MCH and dopamine. Peptides 19:1007-1016.
    • (1998) Peptides , vol.19 , pp. 1007-1016
    • Gonzalez, M.I.1    Baker, B.I.2    Hole, D.R.3    Wilson, C.A.4
  • 29
    • 0030011182 scopus 로고    scopus 로고
    • How do antidepressants affect serotonin receptors? the role of serotonin receptors in the therapeutic and side effect profile of SSRIs
    • Goodwin GM. 1996. How do antidepressants affect serotonin receptors? The role of serotonin receptors in the therapeutic and side effect profile of SSRIs. J Clin Psychiatry 57(Suppl 4):9-13.
    • (1996) J Clin Psychiatry , vol.57 , Issue.SUPPL. 4 , pp. 9-13
    • Goodwin, G.M.1
  • 30
    • 0034005858 scopus 로고    scopus 로고
    • The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat
    • Hervien GJ, Cluderay JE, Harrison D, Meakin J, Maycox P, Nasir S, Leslie RA. 2000. The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur J Neurosci 12:1194-1216.
    • (2000) Eur J Neurosci , vol.12 , pp. 1194-1216
    • Hervien, G.J.1    Cluderay, J.E.2    Harrison, D.3    Meakin, J.4    Maycox, P.5    Nasir, S.6    Leslie, R.A.7
  • 32
    • 0037126172 scopus 로고    scopus 로고
    • Individual response profiles of male Wistar rats in animal models for anxiety and depression
    • Ho Y-J, Eichendorff J, Schwarting RKW. 2002. Individual response profiles of male Wistar rats in animal models for anxiety and depression. Behav Brain Res 136:1-12.
    • (2002) Behav Brain Res , vol.136 , pp. 1-12
    • Ho, Y.-J.1    Eichendorff, J.2    Schwarting, R.K.W.3
  • 35
    • 0032747157 scopus 로고    scopus 로고
    • Structure-activity relationships at the monoamine transporters and σ receptors for a novel series of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)- propyl]carbazole (rimcazole) analogues
    • Husbands SM, Izenwasser S, Kopajtic T, Bowen WD, Vilner BJ, Katz JL, Newman AH. 1999. Structure-activity relationships at the monoamine transporters and σ receptors for a novel series of 9-[3-(cis-3,5-dimethyl-1- piperazinyl)-propyl]carbazole (rimcazole) analogues. J Med Chem 42:4446-4455.
    • (1999) J Med Chem , vol.42 , pp. 4446-4455
    • Husbands, S.M.1    Izenwasser, S.2    Kopajtic, T.3    Bowen, W.D.4    Vilner, B.J.5    Katz, J.L.6    Newman, A.H.7
  • 36
    • 29544448682 scopus 로고    scopus 로고
    • MCH-1 receptor antagonists, lundbeck
    • IDdb3. 2005. MCH-1 receptor antagonists, Lundbeck. The Investigational Drug Database Drug Report. Available on line at www.iddb3.com.
    • (2005) The Investigational Drug Database Drug Report
  • 38
    • 0026535615 scopus 로고
    • Rat melanin-concentrating hormone stimulates adrenocorticotropin secretion: Evidence for a site of action in brain regions protected by the blood-brain barrier
    • Jezova D, Bartanusz V, Westergren I, Johansson BB, Rivier J, Vale W, Rivier C. 1992. Rat melanin-concentrating hormone stimulates adrenocorticotropin secretion: evidence for a site of action in brain regions protected by the blood-brain barrier. Endocrinology 130:1024-1029.
    • (1992) Endocrinology , vol.130 , pp. 1024-1029
    • Jezova, D.1    Bartanusz, V.2    Westergren, I.3    Johansson, B.B.4    Rivier, J.5    Vale, W.6    Rivier, C.7
  • 39
    • 0026026039 scopus 로고
    • Sex differences in animal tests of anxiety
    • Johnson AL, File SE. 1991. Sex differences in animal tests of anxiety. Physiol Behav 49:245-250.
    • (1991) Physiol Behav , vol.49 , pp. 245-250
    • Johnson, A.L.1    File, S.E.2
  • 41
    • 0038460899 scopus 로고    scopus 로고
    • Behavioural analysis of melanin-concentrating hormone in rats: Evidence for orexigenic and anxiolytic properties
    • Kela J, Salmi P, Rimondini-Giorgini R, Heilig M, Wahlestedt C. 2003. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regul Pept 114:109-114.
    • (2003) Regul Pept , vol.114 , pp. 109-114
    • Kela, J.1    Salmi, P.2    Rimondini-Giorgini, R.3    Heilig, M.4    Wahlestedt, C.5
  • 45
    • 4544374046 scopus 로고    scopus 로고
    • Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity
    • Kowalski TJ, McBriar MD. 2004. Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity. Expert Opin Investig Drugs 13:1113-1122.
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 1113-1122
    • Kowalski, T.J.1    McBriar, M.D.2
  • 47
    • 0028067379 scopus 로고
    • Substance P is involved in the sensitization of the acoustic startle response by footshocks in rats
    • Krase W, Koch M, Schnitzler H-U. 1994. Substance P is involved in the sensitization of the acoustic startle response by footshocks in rats. Behav Brain Res 63:81-88.
    • (1994) Behav Brain Res , vol.63 , pp. 81-88
    • Krase, W.1    Koch, M.2    Schnitzler, H.-U.3
  • 49
    • 0030819696 scopus 로고    scopus 로고
    • The forced swimming test as a model for core and component behavioral effects of antidepressant drugs
    • Lucki I. 1997. The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol 8:523-532.
    • (1997) Behav Pharmacol , vol.8 , pp. 523-532
    • Lucki, I.1
  • 56
    • 0032739396 scopus 로고    scopus 로고
    • Response to novelty after i.c.v injection of melanin-concentrating hormone (MCH) in rats
    • Monzón ME, De Barioglio SR. 1999. Response to novelty after i.c.v injection of melanin-concentrating hormone (MCH) in rats. Physiol Behav 67:813-817.
    • (1999) Physiol Behav , vol.67 , pp. 813-817
    • Monzón, M.E.1    De Barioglio, S.R.2
  • 57
    • 0034973992 scopus 로고    scopus 로고
    • Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain
    • Monzón ME, Varas MM, De Barioglio SR. 2001. Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain. Peptides 22:1043-1047.
    • (2001) Peptides , vol.22 , pp. 1043-1047
    • Monzón, M.E.1    Varas, M.M.2    De Barioglio, S.R.3
  • 60
    • 0028815653 scopus 로고
    • Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
    • Nibuya M, Morinobu S, Duman RS. 1995. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15:7539-7547.
    • (1995) J Neurosci , vol.15 , pp. 7539-7547
    • Nibuya, M.1    Morinobu, S.2    Duman, R.S.3
  • 61
    • 1842587437 scopus 로고    scopus 로고
    • Trends in the development of new antidepressants. Is there a light at the end of the tunnel?
    • Pacher P, Kecskemeti V. 2004. Trends in the development of new antidepressants. Is there a light at the end of the tunnel? Curr Med Chem 11:925-943.
    • (2004) Curr Med Chem , vol.11 , pp. 925-943
    • Pacher, P.1    Kecskemeti, V.2
  • 63
    • 0034991368 scopus 로고    scopus 로고
    • Animal models of anxiety and depression: How are females different?
    • Palanza P. 2001. Animal models of anxiety and depression: how are females different? Neurosci Biobehav Rev 25:219-233.
    • (2001) Neurosci Biobehav Rev , vol.25 , pp. 219-233
    • Palanza, P.1
  • 65
    • 0026795891 scopus 로고
    • Rat melanin-concentrating hormone messenger ribonucleic acid expression: Marked changes during development and after stress and glucocorticoid stimuli
    • Presse F, Hervien G, Imaki T, Sawchenko PE, Vale W, Nahon J-L. 1992. Rat melanin-concentrating hormone messenger ribonucleic acid expression: marked changes during development and after stress and glucocorticoid stimuli. Endocrinology 131:1241-1250.
    • (1992) Endocrinology , vol.131 , pp. 1241-1250
    • Presse, F.1    Hervien, G.2    Imaki, T.3    Sawchenko, P.E.4    Vale, W.5    Nahon, J.-L.6
  • 67
    • 0033765025 scopus 로고    scopus 로고
    • Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders
    • Ressler KJ, Nermeroff CB. 2000. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12(Suppl I):2-19.
    • (2000) Depress Anxiety , vol.12 , pp. 2-19
    • Ressler, K.J.1    Nermeroff, C.B.2
  • 68
    • 0030175899 scopus 로고    scopus 로고
    • Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit
    • Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL. 1996. Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron 16:1179-1188.
    • (1996) Neuron , vol.16 , pp. 1179-1188
    • Roche, K.W.1    O'Brien, R.J.2    Mammen, A.L.3    Bernhardt, J.4    Huganir, R.L.5
  • 71
    • 29544437926 scopus 로고    scopus 로고
    • Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects
    • Published Online June 29
    • Roy M, David NK, Danao JV, Baribault H, Tian H, Giogetti M. 2005. Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects. Neuropsychopharmacology, published online June 29.
    • (2005) Neuropsychopharmacology
    • Roy, M.1    David, N.K.2    Danao, J.V.3    Baribault, H.4    Tian, H.5    Giogetti, M.6
  • 73
    • 0032863708 scopus 로고    scopus 로고
    • Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression
    • Russo-Neustadt A, Beard RC, Cotman CW. 1999. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology 21:679-682.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 679-682
    • Russo-Neustadt, A.1    Beard, R.C.2    Cotman, C.W.3
  • 75
    • 0033566084 scopus 로고    scopus 로고
    • Molecular characterization of the melanin-concentrating-hormone receptor
    • Saito Y, Nothacker H-P, Wang Z, Lin SHS, Leslie F, Civelli O. 1999. Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400:265-269.
    • (1999) Nature , vol.400 , pp. 265-269
    • Saito, Y.1    Nothacker, H.-P.2    Wang, Z.3    Shs, L.4    Leslie, F.5    Civelli, O.6
  • 77
    • 0000264756 scopus 로고
    • The catecholamine hypothesis of affective disorders: A review of supporting evidence
    • Schildkraut JJ. 1965. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 122:509-522.
    • (1965) Am J Psychiatry , vol.122 , pp. 509-522
    • Schildkraut, J.J.1
  • 83
    • 0031431373 scopus 로고    scopus 로고
    • Are SSRIs better that TCAs? Comparison of SSRIs and TCAs: A meta-analysis
    • Steffens DC, Krishnan KRR, Helms MJ. 1997. Are SSRIs better that TCAs? Comparison of SSRIs and TCAs: a meta-analysis. Depress Anxiety 6:10-18.
    • (1997) Depress Anxiety , vol.6 , pp. 10-18
    • Steffens, D.C.1    Krishnan, K.R.R.2    Helms, M.J.3
  • 84
    • 29544452986 scopus 로고    scopus 로고
    • Depression and obesity: A complex relationship
    • Stunkard A, Faith MS, Allison KC. 2004. Depression and obesity: a complex relationship. Psychiatric Times volume 21, issue 11. Available online at www.psychiatrictimes.com.
    • (2004) Psychiatric Times , vol.21 , Issue.11
    • Stunkard, A.1    Faith, M.S.2    Allison, K.C.3
  • 88
    • 0035120455 scopus 로고    scopus 로고
    • Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies
    • Voikar V, Koks S, Vasar E, Rauvala H. 2001. Strain and gender differences in the behavior of mouse lines commonly used in transgenic studies. Physiol Behav 72:271-281.
    • (2001) Physiol Behav , vol.72 , pp. 271-281
    • Voikar, V.1    Koks, S.2    Vasar, E.3    Rauvala, H.4
  • 89
    • 0035860811 scopus 로고    scopus 로고
    • Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2
    • Wang S, Behan J, O'Neill K, Weig B, Fried S, Laz T, Bayne M, Gustafson E, Hawes BE. 2001. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2. J Biol Chem 276:34664-34670.
    • (2001) J Biol Chem , vol.276 , pp. 34664-34670
    • Wang, S.1    Behan, J.2    O'Neill, K.3    Weig, B.4    Fried, S.5    Laz, T.6    Bayne, M.7    Gustafson, E.8    Hawes, B.E.9
  • 90
    • 0025978937 scopus 로고
    • Long-term studies of mental health after the Greenville gastric bypass operation for morbid obesity
    • Waters GS, Pories WJ, Swanson MS, Meelheim HD, Flickinger EG, May HJ. 1991. Long-term studies of mental health after the Greenville gastric bypass operation for morbid obesity. Am J Surg 161:154-158.
    • (1991) Am J Surg , vol.161 , pp. 154-158
    • Waters, G.S.1    Pories, W.J.2    Swanson, M.S.3    Meelheim, H.D.4    Flickinger, E.G.5    May, H.J.6
  • 92
    • 8444239400 scopus 로고    scopus 로고
    • Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice
    • Zhou D, Shen Z, Strack AM, Marsh DJ, Shearman LP. 2005. Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice. Regul Pept 124:53-63.
    • (2005) Regul Pept , vol.124 , pp. 53-63
    • Zhou, D.1    Shen, Z.2    Strack, A.M.3    Marsh, D.J.4    Shearman, L.P.5


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