Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: Nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 2, 2005, Pages 831-839

  Chaki, Shigeyuki ^a   Funakoshi, Takeo ^a   Hirota Okuno, Shiho ^a   Nishiguchi, Mariko ^a   Shimazaki, Toshiharu ^a   Iijima, Michihiko ^a   Grottick, Andrew J ^b   Kanuma, Kosuke ^a   Omodera, Katsunori ^a   Sekiguchi, Yoshinori ^a   Okuyama, Shigeru ^a   Tran, Thuy Anh ^b   Semple, Graeme ^b   Thomsen, William ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b ARENA PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; ATC 0065; ATC 0175; CHLORDIAZEPOXIDE; CYCLOPEPTIDE; DIAZEPAM; FLUVOXAMINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; N [4 [[4 (DIMETHYLAMINO)QUINAZOLIN 2 YL]AMINO]CYCLOHEXYL] 3,4 DIFLUOROBENZAMIDE; N [[6 (DIMETHYLAMINO)METHYL] 5,6,7,8 TETRAHYDRO 2 NAPHTHALENYL] 4' FLUORO(1,1' BIPHENYL) 4 CARBOXAMIDE; N2 [4 [[2 [4 BROMO 2 (TRIFLUOROMETHOXY)PHENYL]ETHYL]AMINO]CYCLOHEXYL] N4,N4 DIMETHYLQUINAZOLINE 2,4 DIAMINE; SEROTONIN UPTAKE INHIBITOR; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG RECEPTOR BINDING; EMOTION; ENERGY BALANCE; FEEDING BEHAVIOR; FEMALE; FORCED SWIMMING TEST; GUINEA PIG; HUMAN; HUMAN CELL; HYPERTHERMIA; HYPOTHALAMUS; IC 50; IMMOBILIZATION; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SOCIAL INTERACTION; VOCALIZATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; CHO CELLS; CRICETINAE; CYCLOHEXYLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MICE; MICE, INBRED ICR; PREGNANCY; PROTEIN BINDING; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SOMATOSTATIN; STRESS;

EID: 20944435410     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.081711     Document Type: Article

References (43)

1. An S, Cutler G, Zhao JJ, Huang SG, Tian H, Li W, Liang L, Rich M, Bakleh A, Du J, et al. (2001) Identification and characterization of a melanin-concentrating hormone receptor. Proc Natl Acad Sci USA 98:7576-7581.
2. Bachner D, Kreienkamp H, Weise C, Buck F, and Richter D (1999) Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1). FEBS Lett 457:522-524.
3. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, and Sawchenko PE (1992) The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 319:218-245.
4. Borowsky B, Durkin MM, Ogozalek K, Marzabadi MR, DeLeon J, Lagu B, Heurich R, Lichtblau H, Shaposhnik Z, Daniewska I, et al. (2002) Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat Med 8:825-830.
5. Borsini F, Podhorna J, and Marazziti D (2002) Do animal models of anxiety predict anxiolytic-like effects of antidepressants? Psychopharmacology (Berl) 163:121-141.
6. Bromidge SM, Dabbs S, Davies DT, Davies S, Duckworth DM, Forbes IT, Gaster LM, Ham P, Jones GE, King FD, et al. (2000) Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl] -6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem 43:1123-1134.
7. Chaki S, Yoshikawa R, Hirota S, Shimazaki T, Maeda M, Kawashima N, Yoshimizu T, Yasuhara A, Sakagami K, Okuyama S, et al. (2004) MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology 46:457-467.
8. Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley JJ, Martin J, Liu WS, et al. (1999) Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature (Lond) 400:261-265.
9. Chen Y, Hu C, Hsu CK, Zhang Q, Bi C, Asnicar M, Hsiung HM, Fox N, Slieker LJ, Yang DD, et al. (2002) Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology 143:2469-2477.
10. Detke MJ, Rickels M, and Lucki I (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology 121:66-72.
11. Eisch AJ, Bolanos CA, de Wit J, Simonak RD, Pudiak CM, Barrot M, Verhaagen J, and Nestler EJ (2003) Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiatry 54:994-1005.
12. File SE and Seth P (2003) A review of 25 years of the social interaction test. Eur J Pharmacol 463:35-53.
13. Gonzalez MI, Vaziri S, and Wilson CA (1996) Behavioral effects of alpha-MSH and MCH after central administration in the female rat. Peptides 17:171-177.
14. Griebel G, Simiand J, Steinberg R, Jung M, Gully D, Roger P, Geslin M, Scatton B, Maffrand JP, and Soubrie P (2002) 4-(2-Chloro-4-methoxy-5- methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl] 5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A), a potent and selective corticotrophin-releasing factor(1) receptor antagonist: II. Characterization in rodent models of stress-related disorders. J Pharmacol Exp Ther 301:333-345.
15. Heinrichs SC, De Souza EB, Schulteis G, Lapsansky JL, and Grigoriadis DE (2002) Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist. Neuropsychopharmacology 27:194-202.
16. Hervieu GJ, Cluderay JE, Harrison D, Meakin J, Maycox P, Nasir S, and Leslie RA (2000) The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur J Neurosci 12:1194-1216.
17. Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, et al. (2001) Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J Biol Chem 276:20125-20129.
18. Jezova D, Bartanusz V, Westergren I, Johansson BB, Rivier J, Vale W, and Rivier C (1992) Rat melanin-concentrating hormone stimulates adrenocorticotropin secretion: evidence for a site of action in brain regions protected by the blood-brain barrier. Endocrinology 130:1024-1029.
19. Kawaguchi H, Kawazoe I, Tsubokawa M, Kishida M, and Baker BI (1983) Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature (Lond) 305:321-323.
20. Kela J, Salmi P, Rimondini-Giorgini R, Heilig M, and Wahlestedt C (2003) Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regul Pept 114:109-114.
21. Kennedy AR, Todd JF, Dhillo WS, Seal LJ, Ghatei MA, O'Toole CP, Jones M, Witty D, Winborne K, Riley G, et al. (2003) Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1. J Neuroendocrinol 15:268-272.
22. Kennett GA, Bright F, Trail B, Baxter GS, and Blackburn TP (1996) Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br J Pharmacol 117:1443-1448.
23. Kennett GA, Trail B, and Bright F (1998) Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology 37:1603-1610.
24. Kokkotou EG, Tritos NA, Mastaitis JW, Slieker L, and Maratos-Flier E (2001) Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology 142:680-686.
25. Lembo PM, Grazzini E, Cao J, Hubatsch DA, Pelletier M, Hoffert C, St-Onge S, Pou C, Labrecque J, Groblewski T, et al. (1999) The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nat Cell Biol 1:267-271.
26. Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, Camacho RE, et al. (2002) Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive and hyperphagic and have altered metabolism. Proc Natl Acad Sci USA 99:3240-3245.
27. Millan MJ, Brocco M, Gobert A, Dorey G, Casara P, and Dekeyne A (2001) Anxiolytic properties of the selective, non-peptidergic CRF(1) antagonists, CP154,526 and DMP695: a comparison to other classes of anxiolytic agent. Neuropsychopharmacology 25:585-600.
28. Molewijk HE, Hartog K, van der Poel AM, Mos J, and Olivier B (1996) Reduction of guinea pig pup isolation calls by anxiolytic and antidepressant drugs. Psychopharmacology (Berl) 128:31-38.
29. Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, et al. (2001) Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Biochem Biophys Res Commun 283:1013-1018.
30. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, and Monteggia LM (2002) Neurobiology of depression. Neuron 34:13-25.
31. Newton SS, Thome J, Wallace TL, Shirayama Y, Schlesinger L, Sakai N, Chen J, Neve R, Nestler EJ, and Duman RS (2002) Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J Neurosci 22:10883-10890.
32. Okuyama S, Chaki S, Kawashima N, Suzuki Y, Ogawa S, Nakazato A, Kumagai T, Okubo T, and Tomisawa K (1999) Receptor binding, behavioral and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001. J Pharmacol Exp Ther 289:926-935.
33. Pompeiano M, Palacios JM, and Mengod G (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 23:163-178.
34. Reeves DL, Levinson DM, Justesen DR, and Lubin B (1985) Endogenous hyperthermia in normal human subjects: experimental study of emotional states (II). Int J Psychosom 32:18-23.
35. Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, et al. (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci USA 98:7564-7569.
36. Saito Y, Cheng M, Leslie FM, and Civelli O (2001) Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J Comp Neurol 435:26-40.
37. Saito Y, Nothacker HP, Wang Z, Lin SH, Leslie F, and Civelli O (1999) Molecular characterization of the melanin-concentrating-hormone receptor. Nature (Lond) 400:265-269.
38. Sears RM, Georgescu D, Maratos-Flier E, Marsh DJ, Nestler EJ, and DiLeone EJ (2004) The neuropeptide MCH controls feeding and mood via action on the nucleus accumbens shell. Soc Neurosci Abstr 763.9.
39. Shimomura Y, Mori M, Sugo T, Ishibashi Y, Abe M, Kurokawa T, Onda H, Nishimura O, Sumino Y, and Fujino M (1999) Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. Biochem Biophys Res Commun 261:622-626.
40. Spooren WPJM, Schoeffer P, Gasparini F, Kuhn R, and Gentsch C (2002) Pharmacological and endocrinological characterization of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608). Eur J Pharmacol 435:161-170.
41. Takekawa S, Asami A, Ishihara Y, Terauchi J, Kato K, Shimomura Y, Mori M, Murakoshi H, Kato K, Suzuki N, et al. (2002) T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur J Pharmacol 438:129-135.
42. Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, et al. (2002) Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 79:785-792.
43. Willner P, Muscat R, and Papp M (1992) Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev 16:525-534.