New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants

Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2001, Pages 418-428

  Martinez Esparza J ^a   Oficialdegui, A M ^a   Perez Silanes S ^a   Heras, B ^a   Orus L ^a   Palop, J A ^a   Lasheras, B ^a   Roca, J ^b   Mourelle, M ^b   Bosch, A ^b   Del Castillo, J C ^b   Tordera, R ^a   Del Rio J ^a   Monge, A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b Vita Invest SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZOTHIOPHENE 3 YL 3 [4 (2 METHOXYPHENYL) 1 YLPROPAN 1 OL]; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL] 1 (1 NAPHTHYLOXY) 1 (THIOPHENE 3 YL)PROPANE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR; CYCLIC AMP; DOPAMINE 2 RECEPTOR; FLUOXETINE; FORSKOLIN; MUSCARINIC RECEPTOR; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PAROXETINE; PIPERAZINE DERIVATIVE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FORCED SWIMMING TEST; HUMAN; HUMAN CELL; INDUCED HYPOTHERMIA; LEARNED HELPLESSNESS; MOUSE; NONHUMAN; RECEPTOR AFFINITY; RECTUM TEMPERATURE; SEROTONINERGIC TRANSMISSION;

ANIMALS; ANTIDEPRESSIVE AGENTS; AVOIDANCE LEARNING; CARRIER PROTEINS; COLONY-FORMING UNITS ASSAY; CONDITIONING, OPERANT; CYCLIC AMP; HELA CELLS; HUMANS; HYPOTHERMIA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; NERVE TISSUE PROTEINS; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 0035254214     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001059j     Document Type: Article

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