Dianhydrohexitole-based benzamidines: An efficient synthesis of new factor Xa inhibitors

Synthesis

Volumn , Issue 8, 2004, Pages 1211-1228

  Vogler, Marko ^a   Koert, Ulrich ^a   Harms, Klaus ^a   Dorsch, Dieter ^b   Gleitz, Johannes ^b   Raddatz, Peter ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Amidines; Cross coupling; Drugs; Factor Xa inhibitors; Isosorbide; Mitsunobu reaction

Indexed keywords

SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

NUCLEOPHILICITY; SELECTIVITY;

AROMATIC COMPOUNDS;

BENZAMIDINE DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR;

ARTICLE; CROSS COUPLING REACTION; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MITSUNOBU REACTION; SUBSTITUTION REACTION;

EID: 2942719116     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-822356     Document Type: Article

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