Design, synthesis, and activity of a novel series of factor Xa inhibitors: Optimization of arylamidine groups

Journal of Medicinal Chemistry

Volumn 45, Issue 12, 2002, Pages 2484-2493

  Phillips, Gary ^a   Guilford, William J ^a   Buckman, Brad O ^a   Davey, David D ^a   Eagen, Keith A ^a   Koovakkat, Sunil ^a   Liang, Amy ^a   McCarrick, Meg ^a   Mohan, Raju ^a   Ng, Howard P ^a   Pinkerton, Michael ^a   Subramanyam, Babu ^a   Ho, Elena ^a   Trinh, Lan ^a   Whitlow, Marc ^a   Wu, Shung ^a   Xu, Wei ^a   Morrissey, Michael M ^a  

^a Discovery Research Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[6 [3 [AMINO(IMINO)METHYL]PHENOXY] 3,5 DIFLUORO 4 METHYLPYRIDIN 2 YL]OXY] N,N DIMETHYLBENZAMIDE; AMIDINE; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; DIMETHYLAMIDE; HYDROGEN; HYDROXYL GROUP; IMIDAZOLINE DERIVATIVE; METHYLAMINE; METHYLIMIDAZOLINE; SERINE; SERINE PROTEINASE; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CHEMICAL BINDING; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; RAT; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

AMIDINES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; FACTOR XA; HUMANS; MODELS, MOLECULAR; RATS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN;

EID: 0037030682     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0200660     Document Type: Article

References (17)

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