Synthesis of dianhydrohexitole-based benzamidines as factor xa inhibitors using cross couplings, phenyl ether and amidine formations as key steps

Synlett

Volumn , Issue 11, 2003, Pages 1683-1687

  Vogler, Marko ^a   Koert, Ulrich ^a   Dorsch, Dieter ^b   Gleitz, Johannes ^b   Raddatz, Peter ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Amidines; Dianhydrohexitoles; Factor Xa inhibitors; Isosorbide; Negishi reaction

Indexed keywords

AMIDINE; BENZAMIDINE DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR; DIPHENYL ETHER; ETHER DERIVATIVE; ISOSORBIDE; PLASMIN; THROMBIN; TRYPSIN;

ARTICLE; CROSS LINKING; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; MITSUNOBU REACTION; PHARMACOPHORE; PROCESS OPTIMIZATION; STEREOCHEMISTRY; SUBSTITUTION REACTION;

EID: 0042411997     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-41426     Document Type: Article

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