Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells

Molecular and Cellular Biology

Volumn 17, Issue 10, 1997, Pages 5946-5951

  Philips, Alexandre ^a,b   Lesage, Sylvie ^a   Gingras, Rock ^a   Maira, Mario Hernan ^a   Gauthier, Yves ^a   Hugo, Patrice ^a   Drouin, Jacques ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PALINDROMIC DNA;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; DNA DETERMINATION; LYMPHOID CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TARGET CELL;

ANIMALIA;

EID: 0030840414     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.10.5946     Document Type: Article

References (42)

1. Autelitano, D. J., and K. E. Sheppard. 1993. Corticotrope responsiveness to glucocorticoids is modulated via rapid CRF-mediated induction of the protooncogene c-fos. Mol. Cell. Endocrinol. 94:111-119.
2. Beato, M. 1989. Gene regulation by steroid hormones. Cell 56:335-344.
3. Boutillier, A. L., D. Monnier, D. Lorang, J. R. Lundblad, J. L. Roberts, and J. P. Loeffler. 1995. Corticotropin-releasing hormone stimulates proopiomelanocortin transcription by cFos-dcpendent and -independent pathways: characterization of an AP1 site in exon 1. Mol. Endocrinol. 9:745-755.
4. Boutillier, A. L., P. Sassone-Corsi, and J. P. Loeffler. 1991. The protooncogene c-fos is induced by corticotropin-releasing factor and stimulates proopiomelanocortin gene transcription in pituitary cells. Mol. Endocrinol. 5: 1301-1310.
5. Calnan, B. J., S. Szychowski, F. K. Chan, D. Cado, and A. Winoto. 1995. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 3:273-282.
6. Chan, R. K., E. R. Brown, A. Ericsson, K. J. Kovacs, and P. E. Sawchenko. 1993. A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J. Neurosci. 13:5126-5138.
7. Cheng, L. E. C., F. K. M. Chan, D. Cado, and A. Winoto. 1997. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 16:1865-1875.
8. Davis, I. J., and L. F. Lau. 1994. Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Mol. Cell. Biol. 14:3469-3483.
9. Drouin, J., Y. L. Sun, M. Chamberland, Y. Gauthier, A. De Léan, M. Nemer, and T. J. Schmidt. 1993. Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J. 12:145-156.
10. Drouin, J., Y. L. Sun, S. Tremblay, P. Lavender, T. J. Schmidt, A. De Léan, and M. Nemer. 1992. Homodimer formation is rate-limiting for high affinity DNA binding by glucocorticoid receptor. Mol. Endocrinol. 6:1299-1309.
11. Drouin, J., M. A. Trifiro, R. K. Plante, M. Nemer, P. Eriksson, and Ö. Wrange. 1989. Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol. Cell. Biol. 9:5305-5314.
12. Forman, B. M., K. Umesono, J. Chen, and R. M. Evans. 1995. Unique response pathways are established by allosteric interactions among nuclear hormone receptors. Cell 81:541-550.
13. Gagner, J.-P., and J. Drouin. 1985. Opposite regulation of pro-opiomelanocortin sene transcription by glucocorticoids and CRH. Mol. Cell. Endocrinol. 40:25-32.
14. Gagner, J.-P., and J. Drouin. 1987. Tissue-specific regulation of pituitary proopiomelanocortin gene transcription by corticotropin-releasing hormone, 3′,5′-cyclic adenosine monophosphate, and glucocorticoids. Mol. Endocrinol. 1:677-682.
15. Hazel, T. G., D. Nathans, and L. F. Lau. 1988. A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc. Natl. Acad. Sci. USA 85:8444-8448.
16. Honkaniemi, J., J. Kononen, T. Kainu, I. Pyykonen, and M. Pelto-Huikko. 1994. Induction of multiple immediate early genes in rat hypothalamic paraventricular nucleus after stress. Brain Res. 25:234-241.
17. Jacobson, L., and J. Drouin. 1994. Regulation of proopiomelanocortin gene transcription, p. 117-138. In H. Imura (ed.). The pituitary gland. Raven Press, New York, N.Y.
18. 2+ channels in rat corticotropes. Endocrinology 137:2269-2277.
19. Lamonerie, T., J. J. Tremblay, C. Lanctôt, M. Therrien, Y. Gauthier, and J. Drouin. 1996. PTX1, a bicoid-related homeobox transcription factor involved in transcription of pro-opiomelanocortin (POMC) gene. Genes Dev. 10: 1284-1295.
20. Law, S. W., O. M. Conneely, F. J. DeMayo, and B. W. O'Malley. 1992. Identification of a new brain-specific transcription factor, NURR1. Mol. Endocrinol. 6:2129-2135.
21. Liu, Z. G., S. W. Smith, K. A. McLaughlin, L. M. Schwartz, and B. A. Osborne. 1994. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 367:281-284.
22. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, et al. 1995. The nuclear receptor superfamily: the second decade. Cell 83:835-839.
23. Milhrandt, J. 1988. Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1:183-188.
24. Murphy, E. P., and O. M. Conneely. 1997. Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors. Mol. Endocrinol. 11:39-47.
25. Nakai, A., S. Kartha, A. Sakurai, F. G. Toback, and L. J. Degroot. 1990. A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Mol. Endocrinol. 4:1438-1443.
26. Ohkura, N., M. Hijikuro, A. Yamamoto, and K. Miki. 1994. Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. Biochem. Biophys. Res. Commun. 205:1959-1965.
27. Parkes, D., S. Rivest, S. Lee, C. Rivier, and W. Vale. 1993. Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus. Mol. Endocrinol. 7:1357-1367.
28. Perlmann, T., and L. Jansson. 1995. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 9:769-782.
29. Philips, A., M. Maira, A. Mullick, M. Chamberland, S. Lesage, P. Hugo, and J. Drouin. 1997. Antagonism between Nur77 and glucocorticoid receptor for control of transcription. Mol. Cell. Biol. 17:5952-5959.
30. 29a. Poulin, G., B. Turgeon, and J. Drovin. NeuroD1/BETA2 contributes to all-specific transcription of the POMC gene. Mol. Cell. Biol., in press.
31. Ryseck, R. P., H. Macdonald-Bravo, M. G. Mattei, S. Ruppert, and R. Bravo. 1989. Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor. EMBO J. 8:3327-3335.
32. Themen, M., and J. Drouin. 1991. Pituitary pro-opiomelanocortin gene expression requires synergistic interactions of several regulatory elements. Mol. Cell. Biol. 11:3492-3503.
33. Therrien, M., and J. Drouin. 1993. Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene. Mol. Cell. Biol. 13:2342-2353.
34. von Dreden, G., J. P. Loeffler, C. Grimm, and V. Hollt. 1988. Influence of calcium ions on proopiomelanocortin mRNA levels in clonal anterior pituitary cells. Neuroendocrinology 47:32-37.
35. Wilson, T. E., T. J. Fahrner, M. Johnston, and J. Milbrandt. 1991. Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252:1296-1300.
36. Wilson, T. E., A. R. Mouw, C. A. Weaver, J. Milbrandt, and K. L. Parker. 1993. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Mol. Cell. Biol. 13:861-868.
37. Wilson, T. E., R. E. Paulsen, K. A. Padgett, and J. Milbrandt. 1992. Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Science 256:107-110.
38. Wolterink, G., E. Van Zanten, H. Kamsteeg, F. S. Radhakishun, and J. M. Van Ree. 1990. Functional recovery after destruction of dopamine systems in the nucleus accumbens of rats. II. Facilitation by the ACTH-(4-9) analog ORG 2766. Brain Res. 507:101-108.
39. Woronicz, J. D., B. Calnan, V. Ngo, and A. Winoto. 1994. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 367:277-281.
40. Woronicz, J. D., A. Lina, B. J. Calnan, S. Szychowski, L. Cheng, and A. Winoto. 1995. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell. Biol. 15:6364-6376.
41. Xiao, Q., S. O. Castillo, and V. M. Nikodem. 1996. Distribution of messenger RNAs lor the orphan nuclear receptors Nurr1 and Nur77 (NGFI-B) in adult rat brain using in situ hybridization. Neuroscience 75:221-230.
42. Yazdanbakhsh, K., J. W. Choi, Y. Li, L. F. Lau, and Y. Choi. 1995. Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc. Natl. Acad. Sci. USA 92:437-441.