메뉴 건너뛰기




Volumn 73, Issue 5, 1999, Pages 2218-2221

Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury

Author keywords

1 Methyl 4 phenyl 1,2,3,6 tetrahydropyridine; Dopaminergic neurons; Knockout mice; Mesencephalon; Nurr1; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BRAIN PROTEIN; NEUROTOXIN; NUCLEAR RECEPTOR RELATED FACTOR 1; UNCLASSIFIED DRUG;

EID: 0032692692     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.02218.x     Document Type: Article
Times cited : (166)

References (25)
  • 1
    • 0001496694 scopus 로고
    • A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Burns R. S., Chiueh C. C., Markey S. P., Ebert M. H., Jacobowitz D. M., and Kopin I. J. (1983) A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA 80, 4546-4550.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 4546-4550
    • Burns, R.S.1    Chiueh, C.C.2    Markey, S.P.3    Ebert, M.H.4    Jacobowitz, D.M.5    Kopin, I.J.6
  • 2
    • 0031805754 scopus 로고    scopus 로고
    • Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene
    • Castillo S. O., Baffi J. S., Palkovits M., Goldstein D. S., Kopin I. J., Witta J., Magnuson M. A., and Nikodem V. M. (1998) Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol. Cell. Neurosci. 11, 36-46.
    • (1998) Mol. Cell. Neurosci. , vol.11 , pp. 36-46
    • Castillo, S.O.1    Baffi, J.S.2    Palkovits, M.3    Goldstein, D.S.4    Kopin, I.J.5    Witta, J.6    Magnuson, M.A.7    Nikodem, V.M.8
  • 4
    • 0002724965 scopus 로고
    • Pathology of Parkinson's disease
    • Calne D. B., ed, W. B. Saunders Co., Philadelphia
    • Fearnley J. and Lees A. (1994) Pathology of Parkinson's disease, in Neurodegenerative Diseases (Calne D. B., ed), pp. 545-554. W. B. Saunders Co., Philadelphia.
    • (1994) Neurodegenerative Diseases , pp. 545-554
    • Fearnley, J.1    Lees, A.2
  • 6
    • 0033574750 scopus 로고    scopus 로고
    • Molecular cloning of the human Nurr1 gene: Characterization of the human gene and cDNAs
    • Ichinose H., Ohye T., Suzuki T., Sumi-Ichinose C., Nomura T., Hagino Y., and Nagatsu T. (1999) Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs. Gene 230, 233-239.
    • (1999) Gene , vol.230 , pp. 233-239
    • Ichinose, H.1    Ohye, T.2    Suzuki, T.3    Sumi-Ichinose, C.4    Nomura, T.5    Hagino, Y.6    Nagatsu, T.7
  • 7
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner P. and Olanow W. (1998) Understanding cell death in Parkinson's disease. Ann. Neurol. 44 (Suppl. 1), S72-S84.
    • (1998) Ann. Neurol. , vol.44 , Issue.SUPPL. 1
    • Jenner, P.1    Olanow, W.2
  • 10
    • 0031715849 scopus 로고    scopus 로고
    • Epidemiology versus genetics in Parkinson's disease: Progress in resolving an age-old debate
    • Langston J. W. (1998) Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate. Ann. Neurol. 44 (Suppl. 1), S45-S52.
    • (1998) Ann. Neurol. , vol.44 , Issue.SUPPL. 1
    • Langston, J.W.1
  • 11
    • 0027074637 scopus 로고
    • Identification of a new brain-specific transcription factor, Nurr1
    • Law S. W., Conneely O. M., DeMayo F. J., and Malley B. W. (1992) Identification of a new brain-specific transcription factor, Nurr1. Mol. Endocrinol. 16, 2129-2135.
    • (1992) Mol. Endocrinol. , vol.16 , pp. 2129-2135
    • Law, S.W.1    Conneely, O.M.2    DeMayo, F.J.3    Malley, B.W.4
  • 12
    • 0026749227 scopus 로고
    • 3H]-GBR12935 to measure dopaminergic nerve terminal growth into the developing rat striatum
    • 3H]-GBR12935 to measure dopaminergic nerve terminal growth into the developing rat striatum. Dev. Brain Res. 67, 375-377.
    • (1992) Dev. Brain Res. , vol.67 , pp. 375-377
    • Le, W.D.1    Bostwick, J.R.2    Appel, S.H.3
  • 13
    • 0345443112 scopus 로고    scopus 로고
    • Selective agenesis of mesencephalic dopaminergic neurons in Nurr1 deficient mice
    • Le W. D., Zou L. L., Conneely O. M., He Y., Jankovic J., and Appel S. H. (1998) Selective agenesis of mesencephalic dopaminergic neurons in Nurr1 deficient mice. Mov. Disord. 13 (Suppl. 2), 184.
    • (1998) Mov. Disord. , vol.13 , Issue.SUPPL. 2 , pp. 184
    • Le, W.D.1    Zou, L.L.2    Conneely, O.M.3    He, Y.4    Jankovic, J.5    Appel, S.H.6
  • 14
    • 0028080267 scopus 로고
    • NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3
    • Magest H. V., Rilke O., Bravo R., Senger G., and Kroczek R. A. (1994) NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3. Mol. Endocrinol. 8, 1583-1591.
    • (1994) Mol. Endocrinol. , vol.8 , pp. 1583-1591
    • Magest, H.V.1    Rilke, O.2    Bravo, R.3    Senger, G.4    Kroczek, R.A.5
  • 15
    • 0025964041 scopus 로고
    • The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method
    • Pakkenberg B., Moller A., Gundersen H. J. G., Mouritzen Dam A., and Pakkenberg H. (1991) The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method. J. Neurol. Neurosurg. Psychiatry 54, 30-33.
    • (1991) J. Neurol. Neurosurg. Psychiatry , vol.54 , pp. 30-33
    • Pakkenberg, B.1    Moller, A.2    Gundersen, H.J.G.3    Mouritzen Dam, A.4    Pakkenberg, H.5
  • 16
    • 0032913951 scopus 로고    scopus 로고
    • The role of inheritance in sporadic Parkinson's disease: Evidence from a longitudinal study of dopaminergic function in twins
    • Piccini P., Burn D. J., Ceravolo R., Maraganore D., and Brooks D. J. (1999) The role of inheritance in sporadic Parkinson's disease: evidence from a longitudinal study of dopaminergic function in twins. Ann. Neurol. 45, 577-582.
    • (1999) Ann. Neurol. , vol.45 , pp. 577-582
    • Piccini, P.1    Burn, D.J.2    Ceravolo, R.3    Maraganore, D.4    Brooks, D.J.5
  • 18
    • 0030093827 scopus 로고    scopus 로고
    • Comparative distribution of Nurr1 and Nur77 nuclear receptors in the mouse central nervous system
    • Saucedo-Cardenas O. and Conneely O. M. (1996) Comparative distribution of Nurr1 and Nur77 nuclear receptors in the mouse central nervous system. J. Mol. Neurosci. 7, 51-63.
    • (1996) J. Mol. Neurosci. , vol.7 , pp. 51-63
    • Saucedo-Cardenas, O.1    Conneely, O.M.2
  • 20
  • 21
    • 0024546234 scopus 로고
    • The role of environmental toxins in the etiology of Parkinson's disease
    • Tanner C. M. (1989) The role of environmental toxins in the etiology of Parkinson's disease. Trends Neurosci. 12, 49-54.
    • (1989) Trends Neurosci. , vol.12 , pp. 49-54
    • Tanner, C.M.1
  • 22
    • 0033574779 scopus 로고    scopus 로고
    • Organization of the human orphan nuclear receptor Nurr1 gene
    • Tori T., Kawarai T., Nakamura S., and Kawakami H. (1999) Organization of the human orphan nuclear receptor Nurr1 gene. Gene 23, 225-232.
    • (1999) Gene , vol.23 , pp. 225-232
    • Tori, T.1    Kawarai, T.2    Nakamura, S.3    Kawakami, H.4
  • 23
    • 0031673714 scopus 로고    scopus 로고
    • The G209A mutation in the α-synuclein gene is not detected in familial cases with Parkinson's disease of non-Greek/ Italian populations
    • Wang W. W., Khajavi M., Patel B. J., Jankovic J., and Ashizawa T. (1998) The G209A mutation in the α-synuclein gene is not detected in familial cases with Parkinson's disease of non-Greek/ Italian populations. Arch. Neurol. 55, 1521-1523.
    • (1998) Arch. Neurol. , vol.55 , pp. 1521-1523
    • Wang, W.W.1    Khajavi, M.2    Patel, B.J.3    Jankovic, J.4    Ashizawa, T.5
  • 24
    • 0000190727 scopus 로고    scopus 로고
    • Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigro-striatal dopamine system
    • Zetterstrom R. H., Williams R., Perlmann T., and Olson L. (1996) Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigro-striatal dopamine system. Mol. Brain Res. 41, 111-120.
    • (1996) Mol. Brain Res. , vol.41 , pp. 111-120
    • Zetterstrom, R.H.1    Williams, R.2    Perlmann, T.3    Olson, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.