The RXRα ligand-dependent activation function 2 (AF-2) is important for mouse development

Development

Volumn 125, Issue 23, 1998, Pages 4691-4707

  Mascrez, Bénédicte ^a   Mark, Manuel ^a   Dierich, Andrée ^a   Ghyselinck, Norbert B ^a   Kastner, Philippe ^a   Chambon, Pierre ^a  

^a l'alimentation et l'Environnement   (France)

Author keywords

Compound mutants; Functional redundancy; Ligand dependent transactivation; Mouse; RAR RXR heterodimers; RAR 2 promoter; Retinoid receptor

Indexed keywords

RETINOID; RETINOID X RECEPTOR; DNA BINDING PROTEIN; LIGAND; PRIMER DNA; RECOMBINANT PROTEIN; RETINOIC ACID RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; EMBRYO; EMBRYO DEVELOPMENT; FETUS DEATH; GENE MUTATION; LIGAND BINDING; MOUSE; NEWBORN DEATH; NONHUMAN; PRIORITY JOURNAL; RETINOL DEFICIENCY; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DEATH; FEMALE; GENE DELETION; GENE LIBRARY; GENETICS; HOMOZYGOTE; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; MULTIPLE MALFORMATION SYNDROME; NEWBORN; NUCLEOTIDE SEQUENCE; PREGNANCY; PRENATAL DEVELOPMENT; PROTEIN SECONDARY STRUCTURE; RESTRICTION MAPPING; SITE DIRECTED MUTAGENESIS; TRANSACTIVATION; VITAMIN D DEFICIENCY;

ANIMALIA; MAMMALIA;

ABNORMALITIES, MULTIPLE; AMINO ACID SEQUENCE; ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; DEATH; DNA PRIMERS; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; GENOMIC LIBRARY; HOMOZYGOTE; LIGANDS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PREGNANCY; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, RETINOIC ACID; RECOMBINANT PROTEINS; RESTRICTION MAPPING; RETINOID X RECEPTORS; SEQUENCE DELETION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; VITAMIN D DEFICIENCY;

EID: 0032217312     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Andrews, N. C. and Faller, D. V. (1991). A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19, 2499.
2. Apfel, C. M., Kamber, M., Klaus, M., Mohr, P., Keidel, S. and Le Motte, P. K. (1995). Enhancement of HL-60 differentiation by a new class of retinoids with selective activity on retinoid X receptor. J. Biol. Chem. 270, 30765-30772.
3. Bavik, C., Ward, S. J. and Chambon, P. (1996). Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis. Proc. Natl. Acad. Sci. USA 93, 3110-3114.
4. Bhattacharyya, N., Dey, A., Minucci, S., Zimmer, A., John, S., Hager, G. and Ozato, K. (1997). Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter. Mol. Cell. Biol. 17, 6481-6490.
5. Blanco, J. C., Dey, A., Leid, M., Minucci, S., Park, B. K., Jurutka, P. W., Haussler, M. R. and Ozato, K. (1996). Inhibition of ligand induced promoter occupancy in vivo by a dominant negative RXR. Genes. Cells. 1, 209-221.
6. Blomhoff, R. (1994). Transport and metabolism of vitamin A. Nutr. Rev. 52, S13-S23.
7. Blumberg, B., Kang, H., Bolado, J.,Jr., Chen, H., Craig, A. G., Moreno, T. A., Umesono, K., Pcrlmann, T., De Robertis, E. M. and Evans, R. M. (1998). BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes Dev. 12, 1269-1277.
8. Botling, J., Castro, D. S., Oberg, F., Nilsson, K. and Perlmann, T. (1997). Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation. J. Biol. Chem. 272, 9443-9449.
9. Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H. and Moras, D. (1995). Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 375, 377-382.
10. Boylan, J. F., Lohnes, D., Taneja, R., Chambon, P. and Gudas, L. J. (1993). Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment. Proc. Natl. Acad. Sci. USA 90, 9601-9605.
11. Boylan, J. F., Lufkin, T., Achkar, C. C., Taneja, R., Chamhon, P. and Gudas, L. J. (1995). Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism. Mol. Cell. Biol. 15, 843-851.
12. Chambon, P. (1994). The retinoid signaling pathway: molecular and genetic analyses. Semin. Cell. Biol. 5, 115-125.
13. Chambon, P. (1996). A decade of molecular biology of retinoic acid receptors. FASEB J. 10, 940-954.
14. Chen, J. Y., Clifford, J., Zusi, C., Starrett, J., Tortolani, D., Ostrowski, J., Reczek, P. R., Chambon, P. and Gronemeyer, H. (1996). Two distinct actions of retinoid-receptor ligands. Nature 382, 819-822.
15. Chen, Z., Iyer, J., Bourguet, W., Held, P., Mioskowski, C., Lebeau, L., Noy, N., Chambon, P. and Gronemeyer, H. (1998). Ligand- and DNA-induced Dissociation of RXR Tetramers. J. Mol. Biol. 275, 55-65.
16. Chiba, H., Clifford, J., Metzger, D. and Chambon, P. (1997a). Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Mol. Cell. Biol. 17, 3013-3020.
17. Chiba, H., Clifford, J., Metzger, D. and Chambon, P. (1997b). Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells. J. Cell. Biol. 139, 735-747.
18. Clifford, J., Chiba, H., Sobieszczuk, D., Metzger, D. and Chambon, P. (1996). RXRalpha-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids. EMBO J. 15, 4142-4155.
19. Costaridis, P., Horton, C., Zeitlinger, J., Holder, N. and Maden, M. (1996). Endogenous retinoids in the zebrafish embryo and adult. Dev. Dyn. 205, 41-51.
20. Defacque, H., Sévilla, C., Piquemal, D., Rochette-Egly, C., Marti, J., and Commes, T. (1997). Potentiation of VD-induced monocytic leukemia cell differentiation by retinoids involves both RAR-and RXR-signaling pathways. Leukemia 11, 221-227.
21. Dey, A. and Ozato, K. (1997). Genomic footprinting of retinoic acid regulated promoters in embryonal carcinoma cells. Methods 11, 197-204.
22. Dickman, E.D., Thaller, C. and Smith, S.M. (1997). Temporally-regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects. Development 124, 3111-3121.
23. Dolle, P., Fraulob, V., Kastner, P. and Chambon, P. (1994). Developmental expression of murine retinoid X receptor (RXR) genes. Mech. Dev. 45, 91-104.
24. Dupe, V., Davenne, M., Brocard, J., Dolle, P., Mark, M., Dierich, A., Chambon, P. and Rijli, F. M. (1997). In vivo functional analysis of the Hoxa-I 3′ retinoic acid response element (3′RARE). Development 124, 399-410.
25. Durand, B., Saunders, M., Gaudon, C., Roy, B., Losson, R. and Chambon, P. (1994). Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13, 5370-5382.