Intraamniotic ethyl docosahexaenoate administration protects fetal rat brain from ischemic stress

Journal of Neurochemistry

Volumn 70, Issue 6, 1998, Pages 2484-2491

  Glozman, Sabina ^a   Green, Pnina ^a,b,c   Yavin, Ephraim ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Docosahexaenoic acid; Fetal brain; Ischemia; Oxidative stress

Indexed keywords

DOCOSAHEXAENOIC ACID; OMEGA 3 FATTY ACID; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; EMBRYO; FETOPLACENTAL UNIT; LIPID PEROXIDATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0031778101     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70062484.x     Document Type: Article

References (39)

1. Alexander-North L. S., North J. A., Kiminyo K. P., Buettner G. R., and Spector A. A. (1994) Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells. J. Lipid Res. 35, 1773-1785.
2. Applegate K. R. and Glomset J. A. (1986) Computer-based modeling of the conformation and packing properties of docosahexaenoic acid. J. Lipid Res. 27, 658-680.
3. Aspberg A. and Tottmar O. (1992) Development of antioxidant enzymes in rat brain and in reaggregation culture of fetal brain cells. Dev. Brain Res. 66, 55-58.
4. Billman G. E., Hallaq H., and Leaf A. (1994) Prevention of ischemia-induced ventricular fibrillation by ω3 fatty acids. Proc. Natl. Acad. Sci. USA 91, 4427-4430.
5. Burdge G. C. and Postle A. D. (1994) Hepatic phospholipid molecular species in the guinea pig. Adaptations to pregnancy. Lipids 29, 259-264.
6. Burton K. (1968) Determination of DNA concentration with diphenylamine. Methods Enzymol. 12B, 163-166.
7. Chen L. Y., Lawson D. L., and Mehta J. L. (1994) Reduction in human neutrophil superoxide ion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. Thromb. Res. 76, 317-322.
8. Corey E. J., Shih C., and Cashman J. R. (1983) Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. Proc. Natl. Acad. Sci. USA 80, 3581-3584.
9. Coyle J. T. and Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
10. Crosby A. J., Wahle K. W. J., and Duthie G. G. (1996) Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1β. Biochim. Biophys. Acta 1303, 187-192.
11. Demoz A., Willumsen N., and Berge R. K. (1992) Eicosapentaenoic acid at hypotriglyceridemic dose enhances the hepatic antioxidant defense in mice. Lipids 27, 968-971.
12. Elphick M. C., Hudson D. G., and Hull D. (1975) Transfer of fatty acids across the rabbit placenta. J. Physiol. (Lond.) 252, 29-42.
13. Esterbauer H. and Cheeseman K. H. (1990) Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 186, 407-421.
14. Esterbauer H., Shauer R. J., and Zollner H. (1991) Chemistry and biochemistry of 4-hydroxynonal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11, 91-128.
15. Glozman S. and Yavin E. (1997) Lipid peroxides are generated by the fetal rat brain after episodes of global ischemia in utero. Neurochem. Res. 22, 201-208.
16. Goel R., Mishra O. P., Razdan B., and Delivoria-Papadopoulos M. (1993) Modification of NMDA receptor by in vitro lipid peroxidation in fetal guinea pig brain. Neurosci. Lett. 151, 219-223.
17. Green P. and Yavin E. (1995) Modulation of fetal rat brain and liver phospholipid content by intraamniotic ethyl docosahexaenoate administration. J. Neurochem. 65, 2555-2560.
18. Green P. and Yavin E. (1996) Fatty acid composition of late embryonic and early postnatal rat brain. Lipids 31, 859-865.
19. Green P., Kamensky B., and Yavin E. (1997) Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration. J. Neurosci. Res. 48, 264-272.
20. Hajra A. and Radin N. S. (1978) Lipid extraction of tissue with a low-toxicity solvent. Anal. Biochem. 90, 420-426.
21. Hall E. D. and Braughler J. M. (1989) Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic. Biol. Med. 6, 303-313.
22. Hall E. D. and Braughler J. M. (1993) Free radicals in CNS injury. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 71, 81-105.
23. Halliwell B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
24. Halliwell B. and Chirico S. (1993) Lipid peroxidation: its mechanism, measurement, and significance. Am. J. Clin. Nutr. 57(Suppl.), 715S-725S.
25. Hatam L. J. and Kayden H. J. (1979) A high-performance liquid chromatographic method for the determination of tocopherol in plasma and cellular elements of the blood. J. Lipid Res. 20, 639-645.
26. Iwasa H., Aono T., and Fukuzawa K. (1990) Protective effect of vitamin E on fetal distress induced by ischemia of the uteroplacental system in pregnant rats. Free Radic. Biol. Med. 8, 393-400.
27. Kukreja R. C., Kontos H. A., Hess M. L., and Ellis E. F. (1986) PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ. Res. 59, 612-619.
28. Larsen L. N., Dahl E., and Bremer J. (1996) Peroxidative oxidation of leuco-dichlorofluorescein by prostaglandin H synthase in prostaglandin biosynthesis from polyunsaturated fatty acids. Biochim. Biophys. Acta 1299, 47-53.
29. Lemaitre D., Vericel E., Polette A., and Lagarde M. (1997) Effects of fatty acids on human platelet glutathione peroxidase: possible role of oxidative stress. Biochem. Pharmacol. 53, 479-486.
30. McGowan J. E., McGowan J. C. 3rd, Mishra O. P., and Delivoria-Papadopoulos M. (1994) Effect of cyclooxygenase inhibition on brain cell membrane lipid peroxidation during hypoxia in newborn piglets. Biol. Neonate 66, 367-375.
31. Mishra O. P. and Delivoria-Papadopoulos M. (1988) Anti-oxidant enzymes in fetal guinea pig brain during development and the effect of maternal hypoxia. Brain Res. 470, 173-179.
32. Mishra O. P. and Delivoria-Papadopoulos M. (1989) Lipid peroxidation in developing fetal guinea pig brain during normoxia and hypoxia. Brain Res. Dev. Brain Res. 45, 129-135.
33. Nalbone G., Leonardi J., Termine E., Portugal H., Lechene P., Pauli A.-M., and Lafont H. (1989) Effects of fish oil, corn oil and lard diets on lipid peroxidation status and glutathione peroxidase activities in rat heart. Lipids 24, 179-186.
34. Relton J. K., Strijbos P. J. L. M., Cooper A. L., and Rothwell N. J. (1993) Dietary n-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat. Brain Res. Bull. 32, 223-226.
35. Sakuraba H. and Tanaka H. (1983) Biochemical analysis of cerebrum of fetal rat x-irradiated in utero. DNA, RNA, superoxide dismutase and lipid peroxide. Brain Dev. 5, 457-463.
36. Shin S. M., Razdan B., Mishra O. P., Johnson L., and Delivoria-Papadopoulos M. (1994) Protective effect of alpha-tocopherol on brain cell membrane function during cerebral cortical hypoxia in newborn piglets. Brain Res. 653, 45-50.
37. Thordstein M. and Nilsson U. A. (1992) Cerebral lipid peroxidation in the growth retarded rat fetus under normoxia and hypoxia. J. Perinat. Med. 20, 15-23.
38. Viani P., Zini I., Cervato G., Biagini G., Agnati L. F., and Cestaro B. (1995) Effect of endothelin-1 induced ischemia on peroxidative damage and membrane properties in rat striatum synaptosomes. Neurochem. Res. 20, 689-695.
39. Yang B., Saldeen T. G. P., Nichols W. W., and Mehta J. L. (1993) Dietary fish oil supplementation attenuates myocardial dysfunction and injury caused by global ischemia and reperfusion in isolated rat hearts. J. Nutr. 123, 2067-2074.