Application of PNA and LNA oligomers to chemotherapy

Current Opinion in Investigational Drugs

Volumn 2, Issue 4, 2001, Pages 558-561

  Elayadi, A N ^a   Corey, D R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Antisense; Bridged nucleic acid; Hybridization; Locked nucleic acid; Oligonucleotide; Peptide nucleic acid; Telomerase

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; DNA; OLIGOMER; PEPTIDE NUCLEIC ACID; PHOSPHOROTHIOIC ACID; RIBONUCLEASE H; RNA; TELOMERASE; TELOMERASE INHIBITOR;

BINDING AFFINITY; BIOCHEMISTRY; CANCER CHEMOTHERAPY; CANCER THERAPY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; IN VIVO STUDY; NONHUMAN; NUCLEIC ACID HYBRIDIZATION; REVIEW; TOXICITY TESTING;

ANIMALS; HUMANS; NUCLEIC ACIDS; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDE NUCLEIC ACIDS; RIBONUCLEASE H, CALF THYMUS; TELOMERASE;

EID: 0035048016     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
2. Antisense and antigene properties of peptide nucleic acids
3. Peptide nucleic acids as therapeutic agents
4. Synthesis of peptide nucleic-acid monomers containing the 4 natural nucleobases - thymine, cytosine, adenine and guanine and their oligomerization
5. Fmoc mediated synthesis of peptide nucleic-acids
6. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules
7. Specific and nonspecific inhibition of transcription by DNA, PNA, and phosphorothioated promoter analog duplexes
8. Interaction of the human NF-kappa B p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappa B binding sites of the human immunodeficiency virus type 1 promoter
9. Stability of peptide nucleic acids in human serum and cellular extracts
10. Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides
11. LNA (Locked Nucleic Acids) - Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation and unprecedented nucleic acid recognition
12. Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing 2′,4′-C-bridged 2′-deoxynucleosides
13. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides
14. Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA
15. Conformationally locked nucleosides. Synthesis and stereochemical assignments of 2′-C,4′-C-bridged bicyclonucleosides
16. The first analogues of LNA (Locked Nucleic Acids) - Phosphorothioated LNA and 2′-thio-LNA
17. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
18. Molecular mechanisms of action of antisense drugs
19. Antisense properties of duplex- and triplex-forming PNAs
20. Solid phase synthesis of directly linked PNA-DNA-hybrids
21. Synthesis and properties of PNA/DNA chimeras
22. Inhibition of gene expression inside cells by peptide nucleic acids: Effect of mRNA target sequence, mismatched bases, and PNA length
23. Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation
24. The telomerase challenge - An unusual challenge for drug discovery
25. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
26. Telomeres shorten during ageing of human fibroblasts
27. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
28. Telomerase activity in human ovarian carcinoma
29. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
30. Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells
31. Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells
32. Decline in telomerase activity as a measure of tumor cell killing by antineoplastic agents in vitro
33. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
34. The RNA component of human telomerase
35. Inhibition of human telomerase by 2′-O-methyl-RNA
36. Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: Effect of length, phosphorothioated substitution, and time inside cells
37. Cellular delivery of peptide nucleic acids and inhibition of human telomerase
38. Pretargeting using peptide nucleic acids
39. In vivo hybridization of technetium-99m-labeled peptide nucleic acid (PNA)
40. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells
41. Peptide nucleic acids targeted to the neurotensin receptor and administered ip cross the blood-brain barrier and specifically reduce gene expression
42. Peptide nucleic acid (PNA) binding-mediated induction of human gamma-globin gene expression
43. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo