Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: Effect of mRNA target sequence and chimera design

Nucleic Acids Research

Volumn 30, Issue 23, 2002, Pages 5160-5167

  Braasch, Dwaine A ^a   Liu, Yinghui ^a   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; LUCIFERASE; MESSENGER RNA; NUCLEIC ACID BASE; OLIGOMER;

5' UNTRANSLATED REGION; BINDING AFFINITY; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE LOCATION; GENE TARGETING; NUCLEIC ACID BASE SUBSTITUTION; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RNA SEQUENCE; START CODON; TRANSLATION REGULATION;

5' UNTRANSLATED REGIONS; ANIMALS; BINDING SITES; CELL LINE; CODON, INITIATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG DESIGN; GENE EXPRESSION REGULATION; LUCIFERASES; NUCLEIC ACID DENATURATION; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TEMPERATURE; TRANSFECTION;

EUKARYOTA;

EID: 0036924811     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf651     Document Type: Review

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