Polymorphisms of the CHRNA4 gene encoding the α4 subunit of nicotinic acetylcholine receptor as related to the oxidative DNA damage and the level of apoptotic proteins in lymphocytes of the patients with Alzheimer' s disease

DNA and Cell Biology

Volumn 24, Issue 12, 2005, Pages 786-794

  Dorszewska, Jolanta ^a   Florczak, Jolanta ^a   Rózycka, Agata ^a   Jaroszewska Kolecka, Joanna ^a   Trzeciak, Wieslaw H ^a   Kozubski, Wojciech ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; INHIBITOR OF APOPTOSIS PROTEIN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTEIN SUBUNIT; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CHRNA4 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA DEGRADATION; DNA REPAIR; EXON; FEMALE; GENE; GENETIC POLYMORPHISM; HUMAN; MALE; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR GENE;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOPTOSIS; BASE SEQUENCE; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; COLLAGEN TYPE XI; DEOXYGUANOSINE; DNA DAMAGE; DNA PRIMERS; DNA-BINDING PROTEINS; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, NICOTINIC; SEQUENCE ANALYSIS, DNA;

EID: 29244449016     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2005.24.786     Document Type: Article

References (59)

1. AGGARWAL, S., and GUPTA, S. (1998). Increased apoptosis of T cell subsets in aging humans: Altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J. Immunol. 160, 1627-1637.
2. ALVES DA COSTA, C., PAITEL, E., MATTSON, M.P., AMSON, R., TELERMAN, A., ANCALIO, K., and CHECLER, F. (2002). Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilins 1 expression in HEK 293 human cells and in murine neurons. Proc. Natl. Acad. Sci. USA 99, 4043-4048.
3. AMES, B.N., and GOLD, L.S. (1991). Endogenous mutagens and the causes of aging and cancer. Mutat. Res. 250, 3-16.
4. BARCISZEWSKI, J., BARCISZEWSKA, M.Z., RATTAN, S.I.S., and CLARK, B.F.C. (1995). The structure and properties of 8-hydroxy-2<-deoxyguanosine-A novel biomarker in aging and carcinogenesis studies. Pol. J. Chem. 69, 841-851.
5. BLASS, J.P., and GIBSON, G.E. (1992). Nonneural markers in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 6, 205-224.
6. BLASS, J.P., SHEU, R.K., and GIBSON, G.E. (2000). Inherent abnormalities in energy metabolism in Alzheimer disease. Interaction with cerebrovascular compromise. Ann. N Y Acad. Sci. 903, 204-221.
7. BRUNER, S.D., NORMAN, D.P., and VERDINE, G.L. (2000). Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature 403, 859-866.
8. CECCHI, C., FIORILLO, C., SORBI, S., LATORRACA, S., NACMIAS, B., BAGNOLI, S., NASSI, P., and LIGURI, G. (2002). Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients. Free Radic. Biol. Med. 33, 1372-1379.
9. CHAVEZ-NORIEGA, L.E., CRONA, J.H., WASHBURN, M.S., URRUTIA, A., ELLIOTT, K.J., and JOHNSON, E.C. (1997). Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 280, 346-356.
10. CHENG, K.C., CAHILL, D.S., KASAI, H., NISHIMURA, S., and LOEB, L.A. (1992). 8-Hydroxyguanine, an abundant from of oxidative DNA damage, causes G-T and A-C substitutions. J. Biol. Chem. 267, 166-172.
11. CHRISTEN, Y. (2000). Oxidative stress and Alzheimer disease. Am. J. Clin. Nutr. 71, 621-629.
12. COOK, L.J., HO, L.W., TAYLOR, A.E., BRAYNE, C., EVANS, J.G., XUEREB, J., CAIRNS, N.J., PRITCHARD, A., LEMMON, H., MANN, D., et al. (2004). Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. Neurosci. Lett. 358, 142-146.
13. CREGAN, S.P., MACLAURIN, J.G., CRAIG, C.G., ROBERTSON, G.S., NICHOLSON, D.W., PARK, D.S., and SLACK, R.S. (1999). Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J. Neurosci. 19, 7860-7869.
14. CULMSEE, C., ZHU, X., YU, Q.S., CHAN, S.L., CAMANDOLA, S., GUO, Z., GREIG, N.H., and MATTSON, M.P. (2001). A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and beta-peptide. J. Neurochem. 77, 220-228.
15. DAVIES, P., and MALONEY, A.J. (1976). Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2, 1403.
16. DE LA MONTE, S.M., SOHN, Y.K., and WANDS, J.R. (1997). Correlaties of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease. J. Neural. Sci. 152, 73-83.
17. DORSZEWSKA, J., and ADAMCZEWSKA-GONCERZEWICZ, Z. (2004). Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain. Respir. Physiol. Neurobiol. 139, 227-236.
18. DORSZEWSKA, J., ADAMCZEWSKA-GONCERZEWICZ, Z., and SZCZECH, J. (2004). Apoptotic proteins in the course of aging of central nervous system. Respir. Physiol. Neurobiol. 139, 145-155.
19. ENGIDAWORK, E., GULESSERIAN, T., SEIDL, R., CAIRNS, N., and LUBEC, G. (2001). Expression of apoptosis related proteins in brains of patients with Alzheimer's disease. Nerosci. Lett. 303, 79-82.
20. FELICIAN, O., and SANDSON, T.A. (1999). The neurobiology and pharmacotherapy of Alzheimer's disease. J. Neropsychiatr. Clin. Neurosci. 11, 19-31.
21. FRAGA, C.G., SHIGENAGA, M.K., PARK, J.W., DEGAN, P., and AMES, B.N. (1990). Oxidative damage to DNA during aging: 8-Hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA 87, 4533-4537.
22. FRANCIS, P.T., PALMER, A.M., and WILCOCK, G.K. (1999). The cholinergic hypothesis of Alzheimer's disease: A review of progress. J. Neurol. Neurosurg. Psychiatry 66, 137-147.
23. GOURAS, G.K., TSAI, J., NASLUND, J., VINCENT, B., EDGAR, M., CHECLER, F., GREENFIELD, J.P., HAROUTUNIAN, V., BUOXBAUM, J.D., XU, H., et al. (2000). Intraneuronal Abeta42 accumulation in human brain. Am. J. Pathol. 156, 15-20.
24. GUAN, Z.Z., ZHANG, X., RAVID, R., and NORDBERG, A. (2000). Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J. Neuchem. 74, 237-243.
25. HELBOCK, H.J., BECKMAN, K.B., SHIGENAGA, M.K., WALTER, P.B., WOODALL, A.A., YEO, H.C., and AMES, B.N. (1998). DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc. Natl. Acad. Sci. USA 95, 288-293.
26. IOUDINA, M., and UEMURA, E. (2003). A three amino acid peptide, Gly-Pro-Arg, protects and rescues cell death induced by amyloid beta-peptide. Exp. Neurol. 184, 923-929.
27. KAWAMATA, J., and SHIMOHAMA, S. (2002). Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. J. Alzheimers Dis. 4, 71-76.
28. LEADON, S.A., and CERUTTI, P.A. (1982). A rapid and mild procedure for the isolation of DNA from mammalian cells. Anal. Biochem. 120, 282-288.
29. LINDSTROM, J., ANAND, R., PENG, X., GERZANICH, V., WANG, F., and LI, Y. (1995). Neuronal nicotinic receptor subtypes. Ann. N Y Acad. Sci. 757, 100-116.
30. LOVE, S., BARBER, R., and WILCOCK, G.K. (1999). Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease. Brain 122, 247-253.
31. MAKI, H., and SEKIGUCHI, M. (1992). MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355, 273-275.
32. MARTIN-RUIZ, C.M., COURT, J.A., MOLNARN, E., LEE, M., GOTTI, C., MAMALAKI, A., TSOULOUFIS, T., TZARTOS, S., BALLARD, C., PERRY, R.H., et al. (1999). Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. J. Neurochem. 73, 1635-1640.
33. MASLIAH, E., MALLORY, M., ALFORD, M., TANAKA, S., and HANSEN, L.A. (1998). Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease. J. Neuropathol. Exp. Neurol. 57, 1041-1052.
34. MASSON, M., NIEDERGANG, C., SCHREIBER, V., MULLER, S., MENISSIER-DE MURCIA, J. and DE MURCIA, G. (1998). XRCC1 is specially associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell Biol. 18, 3563-3571.
35. MATTSON, M.P. (1997). Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivates. Physiol. Rev. 77, 1081-1132.
36. MATTSON, M.P. (2000). Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 1, 120-129.
37. MECOCCI, P., MACGARVEY, U., KAUFMAN, A.E., KOONTZ, D., SHOFFNER, J.M., WALLACE, D.C., and BEAL, M.F. (1993). Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann. Neurol. 34, 609-616.
38. MECOCCI, P., MACGARVEY, U., and BEAL, M.F. (1994). Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36, 747-751.
39. MECOCCI, P., POLIDORI, M.C., INGEGNI, T., CHERUBINI, A., CHIONNE, F., CECCHETTI, R., and SENIN, U. (1998). Oxidative damage to DNA in lymphocytes from AD patients. Neurology 51, 1014-1017.
40. MORI, M., NAKAGAMI, H., MORISHITA, R., MITSUDA, N., YAMAMOTO, K., YOSHIMURA, S., OHKUBO, N., SATO, N., OGIHARA, T., and KANEDA, Y. (2002). N1411 mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci. 70, 2567-2580.
41. MOROCZ, M., KALMAN, J., JUHASZ, A., SINKO, I., MCGLYNN, A.P., DOWNES, C.S., JANKA, Z., and RASKO, I. (2002). Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease: Neurobiol. Aging 23, 47-53.
42. NORDBERG, A. (1994). Human nicotinic receptors-Their role in aging and dementia. Neurochem. Int. 25, 93-97.
43. OHNISHI, T., INOUE, N., MATSUMOTO, H., OMATSU, T., OHIRA, Y., and NAGAOKO, S. (1996). Cellular content of p53 protein in rat skin after exposure to the space environment. J. Appl. Physiol. 81, 183-185.
44. 6-Furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochem. Biophys. Res. Commun. 265, 499-502.
45. PARADIS, E., DOUILLARD, H., KOUTROUMANIS, M., GOODYER, C., and LEBLANC, A. (1996). Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons. J. Neurosci. 16, 7533-7539.
46. PEREZ, R.G., SORIANO, S., HAYES, J.D., OSTASZEWSKI, B., XIA, W., SELKOE, D.J., CHEN, X., STOKIN, G.B., and KOO, E.H. (1999). Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J. Biol. Chem. 274, 18851-18856.
47. PERRY, E.K., PERRY, R.H., BLESSED, G., and TOMLINSON, B.E. (1977). Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1, 189.
48. REED, J.C. (1997). Double identity for proteins of the Bcl-2 family. Nature 387, 773-776.
49. REED, J.C., ZHA, H., AIME-SEMPE, C., TAKAYAMA, S., and WANG, H.G. (1996). Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. Adv. Exp. Med. Biol. 406, 99-112.
50. REPETTO, M.G., REIDES, C.G., EVELSON, P., KOHAN, S., DE LUSTIG, E.S., and LLESUY, S.F. (1999). Peripheral markers of oxidative stress in probable Alzheimer patients. Eur. J. Clin. Invest. 29, 643-649.
51. SU, J.H., DENG, G., and COTMAN, C.W. (1997). Bax protein expression is increased in Alzheimer's brain: Correlations with DNA damage, Bcl-2 expression; and brain pathology. J. Neuropathol. Exp. Neurol. 56, 86-93.
52. TAMAGNO, E., PAROLA, M., GUGLIELMOTTO, M., SANTORO, G., BARDINI, P., MARRA, L., TABATON, M., and DANNI, O. (2003). Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis. Free Radic. Biol. Med. 35, 45-58.
53. WAGNER, J.R., HU, CH.-CH., and AMES, B.N. (1992). Endogenous oxidative damage of deoxycytidine in DNA. Proc. Natl. Acad. Sci. USA 89, 3380-3384.
54. WEVERS, A., MONTEGGIA, L., NOWACKI, S., BLOCH, W., SCHUTZ, U., LINDSTROM, J., PEREIRA, E.F., EISENBERG, H., GIACOBINI, E., DE VOS, R.A., et al. (1999). Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: Histotopatographical correlation with amyloid plaques and hyperphosphorylated-tau protein. Eur. J. Neurosci. 11, 2551-2565.
55. WILSON, C., HENRY, S., SMITH, M.A., and BOWSER, R. (2004). The p53 homologue p73 accumulates in the nucleus and localizes to neurities and neurofibrillary tangles in Alzheimer disease brain. Neuropathol. Appl. Neurobiol. 30, 19-29.
56. YAN, X., XIAO, R., DOU, Y., WANG, S., QIAO, Z., and QIAO, J. (2000). Carbachol bocks beta-amyloid fragment 31-35-induced apoptosis in cultured cortical neurons. Brain Res. Bull. 51, 465-470.
57. YANKNER, B.A. (1996). Mechanism of neuronal degeneration in Alzheimer's disease. Neuron 16, 921-932.
58. YU, S.W., WANG, H., POITRAS, M.F., COOMBS, C., BOWERS, W.J., FEDEROFF, H.J., POIRIER, G.G., DAWSON, T.M., and DAWSON, V.L. (2002). Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 297, 259-263.
59. 1-42 through p53 and Bax in cultured primary human neurons. J. Cell Biol. 156, 519-529.