N141I mutant Presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression

Life Sciences

Volumn 70, Issue 21, 2002, Pages 2567-2580

  Mori, Masaki ^a   Nakagami, Hironori ^a   Morishita, Ryuichi ^a   Mitsuda, Noriaki ^b   Yamamoto, Kei ^a   Yoshimura, Shin Ichi ^c   Ohkubo, Nobutaka ^a,b   Sato, Naoyuki ^a   Ogihara, Toshio ^a   Kaneda, Yasufumi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer's disease; Apoptosis; Bax; Bcl 2; Caspase 3; Presenilin 2; SK N SH

Indexed keywords

CASPASE 3; OXIDOREDUCTASE; PRESENILIN 2; PROTEIN BCL 2;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; FETUS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; NEUROBLASTOMA CELL; PROTEIN EXPRESSION; WILD TYPE;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL COUNT; CLONING, MOLECULAR; CULTURE MEDIA, SERUM-FREE; DNA, COMPLEMENTARY; GENES, BCL-2; HUMANS; L-LACTATE DEHYDROGENASE; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PRESENILIN-2; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 18344362979     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01514-X     Document Type: Article

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