Carbachol blocks β-amyloid fragment 31-35-induced apoptosis in cultured cortical neurons

Brain Research Bulletin

Volumn 51, Issue 6, 2000, Pages 465-470

  Yan, Xiu Zhen ^a   Xiao, Rong ^a   Dou, Yan ^a   Wang, Su Dand ^a   Qiao, Zhong Dong ^a   Qiao, Jian Tian ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

amyloid fragment 31 35; Apoptosis; Carbachol; Cultured neurons; Ladder formation; Mouse; RT PCR assay

Indexed keywords

AMYLOID BETA PROTEIN; CARBACHOL; DNA FRAGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CARBACHOL; CELL CULTURE TECHNIQUES; CEREBRAL CORTEX; CHOLINERGIC AGONISTS; ELECTROPHORESIS; GENE EXPRESSION REGULATION; MICE; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PEPTIDE FRAGMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0034122763     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(99)00255-5     Document Type: Article

References (35)

1. Allsopp T.E., Wyatt S., Paterson H.F., Davies A.M. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell. 3:1993;295-307.
2. Chomczynski P., Sacchit N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
3. Copani A.M., Koh J.Y., Cotman C.W. β-Amyloid increases neuronal susceptibility to injury by glucose deprivation. NeuroReport. 2:1991;763-765.
4. Cotman C.W., Anderson A.J. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10:1995;19-45.
5. Coyle J.T., Price D.L., DeLong M.R. Alzheimer's disease Disorder of cortical cholinergic innervation . Science. 219:1983;1184-1190.
6. Efthimiopoulos S., Vassilacopoulou D., Ripellino J.A., Tezapsidis N., Robakis N.K. Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. Proc. Natl. Acad. Sci. USA. 93:1996;8046-8050.
7. Fukamauchi F., Saunders P.L., Hough C., Chuang D.M. Agonist-induced down-regulation and antagonist-induced up-regulation of m2 and m3 muscarinic acetylcholine receptor mRNA and protein in cultured cerebellar granule neurons. Mol. Pharmacol. 44:1993;940-949.
8. Giacobini E. Invited review Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applications . Neurochem. Int. 32:1998;413-419.
9. Gillardon F., Wickert H., Zimmermann M. Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci Lett. 192:1995;85-88.
10. Hay J.W., Enst R.L. The economic costs of Alzheimer's disease. Am. Pub. Health. 77:1987;1169-1175.
11. Hosey M.M. Diversity of structure, signaling and regulation within the family of muscarinic cholinergic receptors. FASEB J. 6:1992;845-852.
12. Kihara T., Shimohama S., Sawada H., Kimura J., Kume T., Kochiyama H., Maeda T., Akaike A. Nicotine receptor stimulation protects neurons against beta-amyloid toxicity in cultured rat cortical neurons. Ann. Neurol. 42:1997;159-163.
13. Koh J.Y., Yang L.L., Cotman C.W. Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res. 533:1990;315-320.
14. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewicz A.J., Cotman C.W. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. USA. 90:1993;7951-7955.
15. Mesulam M.M., Mufson E.J. Neural inputs into the nucleus basalis of the substantial innominata (Ch4) in the rhesus monkey. Brain. 107:1984;253-274.
16. Mesulam M.M., Geyla C. Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain Observations based on the distribution on acetylcholinesterase and choline acetyltransferase . J. Comp. Neurol. 274:1988;216-240.
17. Moore K.J., Matlashewski G. Intracellular infection by Leishmania Donovani inhibits macrophage apoptosis. J. Immunol. 3152:1994;2930-2937.
18. Ochman H., Gerber A.S., Hartl D.L. Genetic applications of an inverse polymerase chain reaction. Genetics. 120:1988;621-627.
19. Oltval Z.N., Milliman C.L., Korsmeyer J.K. bcl-2 Heterodimerizes in vivo with a conserved homology, bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
20. Pericak-Vance M.A., Yamaoka L.H., Haynes C.S., Speer M.C., Haines J.L., Gaskell P.C., Hung W.Y., Clak C.M., Heyman A.L., Trofatter J.A., Eisenmenger J.P., Gilbert J.R., Lee J.E., Alberts M.L., Dawson D.V., Bartlett R.J., Earl N.L., Siddique T., Vance J.M., Conneally P.M., Roses A.D. Genetic linkage studies in Alzheimer's disease families. Exp. Neurol. 102:1988;271-279.
21. Perry E.K. The cholinergic hypothesis - ten years on. Brit. Med. Bull. 42:1986;63-69.
22. Pike C.J., Walencewicz A.J., Glabe C.G., Cotman C.W. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563:1991;311-314.
23. Pike C.J., Walencewicz A.J., Kosmoski J., Cribbs D.H., Glabe C.G., Cotman C.W. Structure-activity analyses of β-amyloid peptides Contributions of the β25-35 region to aggregation and neurotoxicity . J. Neurochem. 64:1995;253-265.
24. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M., Schreiber S.S. p53 induction is associated with neuronal damage in the central nervous system. Proc. Natl. Acad. Sci. USA. 9:1994;7525-7529.
25. Schwartz J.P., Nishiyama N., Wilson D., Taniwaki T. Receptor-mediated regulation of neuropeptide gene expression in astrocytes. Glia. 11:1994;185-190.
26. Shastry B.S., Giblin F.J. Genes and susceptible loci of Alzheimer's disease. Brain Res. Bull. 48:1999;121-127.
27. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron. 6:1991;487-498.
28. Smeyne R.J., Vendrell M., Hayward M., Baker S.J., Miao G.G., Schilling K., Robertson L.M., Curran T., Morgan J.T. Continuous c-fos expression precedes programmed cell death in vivo. Nature. 63:1993;166-169.
29. Smith P.I. Detection of multidrug resistance and quantification of response of human tumor cells to cytotoxic agents using flow cytometric spectral shift analysis of Hoechst 33342-DNA fluorescence. Cancer Chemother. Pharmacol. 27:1991;445.
30. Walace W.C. Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Mole. Brain Res. 10:1991;173-178.
31. Whitehouse P.J. Alzheimer's disease and senile dementia Loss of neurons in the basal forebrain . Science. 215:1982;1237-1239.
32. Yan G.M., Lin S.Z., Irwin R.P., Paul S.M. Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol. Phamacol. 47:1991;248-257.
33. Yan X.Z., Qiao J.T., Dou Y., Qiao Z.D. β-Amyloid peptide fragment 31-35 induces apoptosis in cultured cortical neurons. Neuroscience. 92:1999;177-184.
34. Yan, X. Z.; Qiao, J. T.; Dou, Y.; Wang, S. D.; Qiao, Z. D. Expression of bcl-2, bax, p53, and c-fos genes during apoptosis induced by β-amyloid fragment 31-35 in cultured cortical neurons. Chin. J. Neurosci. 1999 (in press).
35. Zamani, M. R., Allen, Y. S., Oven, G. P., Gray, J. A. Nicotine modulates the neurotoxic effect of β-amyloid protein (25-35) in hippocampal cultures. NeuroReport 8:513-517; 1997.