CD18 is required for optimal development and function of CD4 +CD25+ T regulatory cells

Journal of Immunology

Volumn 175, Issue 12, 2005, Pages 7889-7897

  Marski, Marissa ^a   Kandula, Sravanthi ^a   Turner, Jerrold R ^a   Abraham, Clara ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; CD4 ANTIGEN; CELL ADHESION MOLECULE; INTERLEUKIN 2 RECEPTOR ALPHA; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANIMAL CELL; ANTIGEN DETECTION; ARTICLE; AUTOIMMUNE DISEASE; CELL CONTACT; CELL FUNCTION; CELL MATURATION; CELL SURFACE; CELL TRANSFER; COLITIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

EID: 29144533904     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.12.7889     Document Type: Article

References (65)

1. + T regulatory cells. J. Exp. Med. 199: 323-335,
2. Aluvihare, V. R., M. Kallikourdis, and A. G. Betz. 2004. Regulatory T cells mediate maternal tolerance to the fetus. Nat. Immunol. 5: 266-271.
3. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
4. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12: 431-440.
5. + regulatory T cells in autoimmune polyglandular syndrome type II. J. Exp. Med. 199; 1285-1291.
6. + regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 199: 971-979.
7. + regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J. Exp. Med. 198: 259-266.
8. + immunoregulatory T cells. J. Exp. Med. 194: 427-438.
9. + T regulatory cells. Nat. Immunol. 4: 337-342.
10. - T cells. J. Clin. Invest. 112: 1437-1443.
11. +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167: 188-195.
12. + Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16: 183-191.
13. Apostolou, I., and H. von Boehmer. 2004. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199: 1401-1408.
14. + regulatory T cells. J. Exp. Med. 199: 303-313.
15. + regulatory T cells. J. Autoimmun. 21: 261-271.
16. + regulatory T cells impaired for intestinal homing can prevent colitis. J. Immunol. 174: 7487-7491.
17. - T regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 104: 3804-3812.
18. Lub, M., Y. van Kooyk, and C. G. Figdor. 1995. Ins and outs of LFA-1. Immunol. Today 16: 479-483.
19. Berlin-Rufenach, C., F. Otto, M. Mathies, J. Westermann, M. J. Owen. A. Hamann, and N. Hogg. 1999. Lymphocytes migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J. Exp. Med. 189: 1467-1478.
20. Abraham, C., J. Griffith, and J. Miller. 1999. The dependence for leukocyte function-associated antigen-1/ICAM-1 interactions in T cell activation cannot be overcome by expression of high density TCR ligand. J. Immunol. 162: 4399-4405.
21. Abraham, C., and J. Miller. 2001. Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. J. Immunol. 167: 5193-5201.
22. + T cells is required for optimal antigen-dependent activation in vivo. J. Immunol. 173: 4443-4451.
23. Larson, R. S., and T. A. Springer. 1990. Structure and function of leukocyte integrins. Immunol. Rev. 114: 181-217.
24. 2 integrins and selectin ligands. Curr. Opin. Hematol. 9: 30-35.
25. Uzel, G., D. E, Kleiner, D. B. Kuhns, and S. M, Holland. 2001, Dysfunctional LAD-1 neutrophils and colitis. Gastroenterology 121: 958-964.
26. Schmits, R., T. M. Kundig, D. M. Baker, G. Shumaker, J. J. Simard, G. Duncan, A. Wakeham, A. Shaninian, A. van der Heiden, M. F. Bachmann, et al. 1996. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183: 1415-1426.
27. Schonlau, F., K. Scharffetter-Kochanek, S. Grabbe, B. Pietz, C. Sorg, and C. Sunderkotter. 2000. In experimental leishmaniasis deficiency of CD18 results in parasite dissemination associated with altered macrophage functions and incomplete Th1 cell response. Eur. J. Immunol. 30: 2729-2740.
28. Scharffetter-Kochanek, K., H. Lu, K. Norman, N. van Nood, F. Munoz, S. Grabbe, M. McArthur, I. Lorenzo, S. Kaplan, K. Ley, et al. 1998. Spontaneous skin ulceration and defective T cell function in CD18 null mice. J. Exp. Med. 188: 119-131.
29. Andrew, D. P., J. P. Spellberg, H. Takimoto, R. Schmits, T. W. Mak, and M. M. Zukowski. 1998. Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice. Eur. J. Immunol. 28: 1959-1969.
30. Scharffetter-Kochanek, K., K. Norman, D. C. Bullard, I. Lorenzo, N. P. van Nood, S. Rich, W. Smith, and A. L. Beaudet. 1996. Generation and characterization of a CD18 complete knock-out mouse: new insights in the function of the CD18 molecule? J. Invest. Dermatol. 106: 809.
31. + T lymphocytes. Int. Immunol. 16: 345-351.
32. Newberry, R. D., W. F. Stenson, and R. G. Lorenz. 1999. Cydooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nat. Med. 5: 900-906.
33. King, C., A. Ilic, K. Koelsch, and N. Sarvetnick. 2004. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117: 265-277.
34. Anderson, M. S., E. S. Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401.
35. Lee, S. H., J. E. Prince, M. Rais, F. Kheradmand, F. Shardonofsky, H. Lu, A. L. Beaudet, C. W. Smith, L. Soong, and D. B. Corry. 2003. Differential requirement for CD18 in T helper effector homing. Nat. Med. 9: 1281-1286.
36. + regulatory T cells. J. Immunol 170: 3939-3943.
37. + regulatory T cells by oral antigen administration. J. Immunol 167: 4245-4253.
38. + T regulatory cell subset has optimal suppressive and proliferative potential. Am. J. Transplant 4: 65-78.
39. Barthlott, T., G. Kassiotis, and B. Stockinger. 2003. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197: 451-460.
40. + Tregs and immune control. J Clin. Invest. 114: 1209-1217.
41. + regulatory T cells in vivo requires B7 costimulation, but not the thymus. J. Exp. Med. 201: 127-137.
42. + T regulatory cell development during the neonatal period. J. Exp. Med. 201: 769-777.
43. Tai, X., M. Cowan, L. Feigenbaum, and A. Singer. 2005. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol 6: 152-162.
44. + regulatory T cells induced by an agonist self-peptide. Nat Immunol 2: 301-306.
45. + T cell receptors. Immunity 21: 267-277.
46. van Santen, H. M., C. Benoist, and D. Mathis. 2004. Number of Treg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 200: 1221-1230.
47. Kuhlman, P., V. T. Moy, B. A. Lollo, and A. A. Brian. 1991. The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation: contributions of adhesion and co-activation. J. Immunol. 146: 1773-1782.
48. Bachmann, M. F., K. McKall-Faienza, R. Schmits, D. Bouchard, J. Beach, D. E. Speiser, T. W. Mak, and P. S. Ohashi. 1997. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity 7: 549-557.
49. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
50. + regulatory T cells responsible for protection against diabetes. Proc. Natl. Acad. Sci. USA 101: 4572-4577.
51. - cells to develop suppressive activity: the role of IL-2, TGF-β, and IL-10. J. Immunol. 172: 5213-5221.
52. + regulatory T cells by peripheral expansion. J. Immunol. 173: 7259-7268.
53. Mellor, A. L., B. Baban, P. Chandler, B. Marshall, K. Jhaver, A. Hansen, P. A. Koni, M. Iwashima, and D. H. Munn. 2003. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J. Immunol. 171: 1652-1655.
54. Grohmann, U., C. Orabona, F. Fallarino, C. Vacca, F. Calcinaro, A. Falorni, P. Candeloro, M. L. Belladonna, R. Bianchi, M. C. Fioretti, and P. Puccetti. 2002. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol 3: 1097-1101.
55. + T cells restrain the maturation and antigen-presenting function of dendritic cells. J. Immunol. 172: 4676-4680.
56. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 629-644.
57. Grossman, W. J., J. W. Verbsky, W. Barchet, M. Colonna, J. P. Atkinson, and T. J. Ley. 2004, Human T regulatory cells can use the perform pathway to cause autologous target cell death. Immunity 21: 589-601.
58. Watanabe, T., and J. Fan. 1998. Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis. Int. J. Cardiol. 66(Suppl. 1): S45-S53; discussion S55.
59. Moriyama, H., K. Yokono, K. Amano, M. Nagata, Y. Hasegawa, N. Okamoto, K. Tsukamoto, M. Miki, R. Yoneda, N. Yagi, et al. 1996. Induction of tolerance in murine autoimmune diabetes by transient blockade of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 pathway. J. Immunol. 157: 3737-3743.
60. Taniguchi, T., H. Tsukada, H. Nakamura, and Y. Seino. 1996. The effects of the anti-ICAM-1 monoclonal antibody on acute DSS colitis. Gastroenterology 110: A1025.
61. Sykulev, Y., Y, Vugmeyster, A. Brunmark, H. L. Ploegh, and H. N. Eisen. 1998. Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity 9: 475-483.
62. Lenschow, D. J., K. C. Herold, L. Rhee, B. Patel, A. Koons, H.-Y. Qin, E. Fuchs, B. Singh, C. B. Thompson, and J. A. Bluestone, 1996. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity 5: 285-293.
63. + suppressor T cells in vivo. Nat. Immunol. 3: 33-41.
64. 2 integrins and ICAM-1 are involved in establishment of the intestinal mucosal T cell compartment. Immunity 5: 263-273.
65. Lim, H. W., P. Hillsamer, and C. H. Kim. 2004. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J. Clin. Invest. 114: 1640-1649.