Leukocyte adhesion deficiency syndromes: Adhesion and tethering defects involving β2 integrins and selectin ligands

Current Opinion in Hematology

Volumn 9, Issue 1, 2002, Pages 30-35

  Bunting, M ^a   Harris, E S ^a   McIntyre, T M ^a   Prescott, S M ^a   Zimmerman, G A ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 INTEGRIN; CD11 ANTIGEN; CD18 ANTIGEN; INTEGRIN; LIGAND; SELECTIN;

BONE MARROW CELL; CELL INVASION; CELL TRANSFORMATION; GENE EXPRESSION; GENE FUNCTION; GLYCOSYLATION; GOLGI COMPLEX; HOST RESISTANCE; HUMAN; IMMUNE DEFICIENCY; INFLAMMATION; LEUKOCYTE ADHESION DEFICIENCY; MICROBIAL IMMUNITY; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN FAMILY; REVIEW; TISSUE INJURY;

ANTIGENS, CD18; CELL ADHESION; ENDOTHELIUM, VASCULAR; GLYCOSYLATION; HUMANS; INTEGRINS; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; LEUKOCYTES; LIGANDS; MODELS, IMMUNOLOGICAL; MUTATION; SELECTINS;

EID: 0036136424     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200201000-00006     Document Type: Review

References (46)

1. Immunodeficiency diseases caused by defects in phagocytes
2. Leukocyte adhesion deficiencies
3. Leukocyte adhesion deficiency II-from A to almost Z
4. Leukocyte-platelet-endothelial cell adhesive interactions during hemostasis and inflammation
5. The leukocyte integrins
6. A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by beta1 and beta2 integrins
7. Functional alpha4-integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients
8. T-cell function and migration. Two sides of the same coin
9. More than the sum of the parts: Cooperation between leukocyte adhesion receptors during extravasation
10. Of man and mouse: Leukocyte and endothelial adhesion molecule deficiencies
11. Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice
12. Leukocyte arrest during cytokine-dependent inflammation in vivo
13. Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: A juxtacrine system for adhesion and activation of neutrophils
14. Inflammatory roles of P-selectin
15. Cross-talk between cell adhesion molecules regulates the migration velocity of neutrophils
16. Stimulation of P-selectin glycoprotein ligand-1 on mouse neutrophils activates beta 2-integrin mediated cell attachment to ICAM-1
17. P-selectin binding promotes the adhesion of monocytes to VCAM-1 under flow conditions
18. Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization
19. Mechanisms of granulocytosis in the absence of CD18
20. Random locomotion and chemotaxis of human blood polymorphonuclear leukocytes from a patient with leukocyte adhesion deficiency-1: Normal displacement in close quarters via chimneying
21. Mechanisms of leukocyte sequestration in inflamed lungs
22. Avidity regulation of integrins: The driving force in leukocyte adhesion
23. A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1
24. A novel point mutation in CD18 causing the expression of dysfunctional CD11/CD18 leukocyte integrins in a patient with leukocyte adhesion deficiency (LAD)
25. Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain
26. Ligand binding to integrins
27. NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding
28. Identification of the binding site for fibrinogen recognition peptide gamma 383-395 within the alpha(M)I-domain of integrin alpha(M)beta2
29. Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins
30. Leukocyte adhesion deficiency II syndrome, a generalized defect in fucose metabolism
31. Targeted gene disruption demonstrates that P-selectin glycoprotein ligand 1 (PSGL-1) is required for P-selectin-mediated but not E- selectin-mediated neutrophil rolling and migration
32. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1
33. Mechanisms that regulate the function of the selectins and their ligands
34. Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow
35. Golgi nucleotide sugar transport and leukocyte adhesion deficiency II
36. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils
37. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels
38. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing
39. A new type of carbohydrate-deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi
40. Impairment of the Golgi GDP-L-fucose transport and unresponsiveness to fucose replacement therapy in LAD II patients
41. The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter
42. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency
43. The evolution of cell adhesion
44. Leukocyte adhesion deficiency (LAD) type II/carbohydrate deficient glycoprotein (CGD) IIc-founder effect and genotype/phenotype correlation
45. Discontinuation of fucose therapy in LADII causes rapid loss of selectin ligands and rise of leukocyte counts
46. Congenital disorders of glycosylation: Genetic model systems lead the way