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Volumn 12, Issue 8, 2005, Pages 549-557

Experimental mechanisms of diabetic embryopathy and strategies for developing therapeutic interventions

Author keywords

Antioxidant; Apoptosis; Birth defect; Diabetes; Embryopathy; Hyperglycemia; Intervention; Lipid peroxidation; Malformation; Mitogen activated protein kinase; Oxidative stress; Protein kinase C

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; GLUTATHIONE ETHYL ESTER; MEMBRANE LIPID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; THIOCTIC ACID; THIONEINE;

EID: 28444486644     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsgi.2005.07.005     Document Type: Review
Times cited : (59)

References (150)
  • 1
    • 0037363595 scopus 로고    scopus 로고
    • Congenital malformations in offspring of diabetic mothers - Animal and human studies
    • U.J. Eriksson, J. Cederberg, P. Wentzel Congenital malformations in offspring of diabetic mothers - Animal and human studies Rev Endocr Metab Disord 4 2003 79 93
    • (2003) Rev Endocr Metab Disord , vol.4 , pp. 79-93
    • Eriksson, U.J.1    Cederberg, J.2    Wentzel, P.3
  • 2
    • 0027636402 scopus 로고
    • Diabetes-related complications of pregnancy
    • E.A. Reece, C.J. Homko Diabetes-related complications of pregnancy J Natl Med Assoc 85 1993 537 545
    • (1993) J Natl Med Assoc , vol.85 , pp. 537-545
    • Reece, E.A.1    Homko, C.J.2
  • 3
    • 0018363182 scopus 로고
    • Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment
    • J.L. Mills, L. Baker, A.S. Goldman Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment Diabetes 28 1979 292 293
    • (1979) Diabetes , vol.28 , pp. 292-293
    • Mills, J.L.1    Baker, L.2    Goldman, A.S.3
  • 4
    • 0842323082 scopus 로고
    • Congenital Malformations: Epidemiology, pathogenesis, and experimental methods of induction and prevention
    • E.A. Reece D.R. Coustan Churchil Livingstone New York
    • E.A. Reece, U.J. Eriksson Congenital Malformations Epidemiology, pathogenesis, and experimental methods of induction and prevention E.A. Reece D.R. Coustan Diabetes Mellitus in Pregnancy 1995 Churchil Livingstone New York 119 154
    • (1995) Diabetes Mellitus in Pregnancy , pp. 119-154
    • Reece, E.A.1    Eriksson, U.J.2
  • 5
    • 0020144915 scopus 로고
    • Malformations in infants of diabetic mothers
    • J.L. Mills Malformations in infants of diabetic mothers Teratology 25 1982 385 394
    • (1982) Teratology , vol.25 , pp. 385-394
    • Mills, J.L.1
  • 6
    • 0017251712 scopus 로고
    • Congenital malformations in infants of diabetic mothers
    • N.G. Soler, C.H. Walsh, J.M. Malins Congenital malformations in infants of diabetic mothers Q J Med 45 1976 303 313
    • (1976) Q J Med , vol.45 , pp. 303-313
    • Soler, N.G.1    Walsh, C.H.2    Malins, J.M.3
  • 7
    • 0028116196 scopus 로고
    • Infant of the diabetic mother
    • E.A. Reece, C.J. Homko Infant of the diabetic mother Semin Perinatol 18 1994 459 469
    • (1994) Semin Perinatol , vol.18 , pp. 459-469
    • Reece, E.A.1    Homko, C.J.2
  • 9
    • 0020291707 scopus 로고
    • Malformations in infants of diabetic mothers
    • A. Grix Jr Malformations in infants of diabetic mothers Am J Med Genet 13 1982 131 137
    • (1982) Am J Med Genet , vol.13 , pp. 131-137
    • Grix, A.1    Jr2
  • 10
    • 0034567025 scopus 로고    scopus 로고
    • Pathogenesis of diabetes-induced congenital malformations
    • U.J. Eriksson, L.A. Borg, J. Cederberg Pathogenesis of diabetes-induced congenital malformations Ups J Med Sci 105 2000 53 84
    • (2000) Ups J Med Sci , vol.105 , pp. 53-84
    • Eriksson, U.J.1    Borg, L.A.2    Cederberg, J.3
  • 11
    • 0028912447 scopus 로고
    • The pathogenesis of congenital malformations in diabetic pregnancy
    • U.J. Eriksson The pathogenesis of congenital malformations in diabetic pregnancy Diabetes Metab Rev 11 1995 63 82
    • (1995) Diabetes Metab Rev , vol.11 , pp. 63-82
    • Eriksson, U.J.1
  • 12
    • 0032833580 scopus 로고    scopus 로고
    • Diabetes and preimplantation events of embryogenesis
    • K.H. Moley Diabetes and preimplantation events of embryogenesis Semin Reprod Endocrinol 17 1999 137 151
    • (1999) Semin Reprod Endocrinol , vol.17 , pp. 137-151
    • Moley, K.H.1
  • 13
    • 0035286621 scopus 로고    scopus 로고
    • Hyperglycemia and apoptosis: Mechanisms for congenital malformations and pregnancy loss in diabetic women
    • K.H. Moley Hyperglycemia and apoptosis Mechanisms for congenital malformations and pregnancy loss in diabetic women Trends Endocrinol Metab 12 2001 78 82
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 78-82
    • Moley, K.H.1
  • 14
    • 0346457636 scopus 로고    scopus 로고
    • Maternal fuels, diabetic embryopathy: Pathomechanisms and prevention
    • E.A. Reece Maternal fuels, diabetic embryopathy pathomechanisms and prevention Semin Reprod Endocrinol 17 1999 183 194
    • (1999) Semin Reprod Endocrinol , vol.17 , pp. 183-194
    • Reece, E.A.1
  • 15
    • 0029966376 scopus 로고    scopus 로고
    • The pathogenesis of diabetes-associated congenital malformations
    • E.A. Reece, U.J. Eriksson The pathogenesis of diabetes-associated congenital malformations Obstet Gynecol Clin North Am 23 1996 29 45
    • (1996) Obstet Gynecol Clin North Am , vol.23 , pp. 29-45
    • Reece, E.A.1    Eriksson, U.J.2
  • 17
    • 0032858266 scopus 로고    scopus 로고
    • Genotoxicity and diabetic embryopathy: Impaired expression of developmental control genes as a cause of defective morphogenesis
    • T.I. Chang, M.R. Loeken Genotoxicity and diabetic embryopathy Impaired expression of developmental control genes as a cause of defective morphogenesis Semin Reprod Endocrinol 17 1999 153 165
    • (1999) Semin Reprod Endocrinol , vol.17 , pp. 153-165
    • Chang, T.I.1    Loeken, M.R.2
  • 19
    • 0027394254 scopus 로고
    • Diabetes and embryonic malformations. Role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos
    • U.J. Eriksson, L.A. Borg Diabetes and embryonic malformations. Role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos Diabetes 42 1993 411 419
    • (1993) Diabetes , vol.42 , pp. 411-419
    • Eriksson, U.J.1    Borg, L.A.2
  • 20
    • 0002638430 scopus 로고
    • Use of animal models in the study of diabetes
    • R. Kahn G.C. Weir Lee & Febiger Malvern, PA
    • A. Karasik, M. Hattori Use of animal models in the study of diabetes R. Kahn G.C. Weir Joslin's Diabetes Mellitus 1994 Lee & Febiger Malvern, PA 317 350
    • (1994) Joslin's Diabetes Mellitus , pp. 317-350
    • Karasik, A.1    Hattori, M.2
  • 21
    • 0031937692 scopus 로고    scopus 로고
    • Animal models of type I (insulin-dependent) diabetes mellitus
    • D. Cheta Animal models of type I (insulin-dependent) diabetes mellitus J Pediatr Endocrinol Metab 11 1998 11 19
    • (1998) J Pediatr Endocrinol Metab , vol.11 , pp. 11-19
    • Cheta, D.1
  • 22
    • 0022624273 scopus 로고
    • Effects of sera from Cohen, genetically determined diabetic rats, streptozotocin diabetic rats and sucrose fed rats on in vitro development of early somite rat embryos
    • A. Ornoy, I. Zusman, A.M. Cohen, E. Shafrir Effects of sera from Cohen, genetically determined diabetic rats, streptozotocin diabetic rats and sucrose fed rats on in vitro development of early somite rat embryos Diabetes Res 3 1986 43 51
    • (1986) Diabetes Res , vol.3 , pp. 43-51
    • Ornoy, A.1    Zusman, I.2    Cohen, A.M.3    Shafrir, E.4
  • 23
    • 84940135842 scopus 로고
    • The effects of high-sucrose diets and of maternal diabetes on the ultrastructure of the visceral yolk sac endoderm in rat embryos developing in vivo and in vitro
    • I. Zusman, P. Yaffe, A. Ornoy The effects of high-sucrose diets and of maternal diabetes on the ultrastructure of the visceral yolk sac endoderm in rat embryos developing in vivo and in vitro Acta Anat (Basel) 128 1987 11 18
    • (1987) Acta Anat (Basel) , vol.128 , pp. 11-18
    • Zusman, I.1    Yaffe, P.2    Ornoy, A.3
  • 24
    • 0036821884 scopus 로고    scopus 로고
    • The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats
    • S.W. Zangen, P. Yaffe, S. Shechtman, D.H. Zangen, A. Ornoy The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats Int J Exp Diabetes Res 3 2002 247 255
    • (2002) Int J Exp Diabetes Res , vol.3 , pp. 247-255
    • Zangen, S.W.1    Yaffe, P.2    Shechtman, S.3    Zangen, D.H.4    Ornoy, A.5
  • 25
    • 0030612870 scopus 로고    scopus 로고
    • Early neonatal events and the disease incidence in nonobese diabetic mice
    • G. Dahlquist, B. Kallen Early neonatal events and the disease incidence in nonobese diabetic mice Pediatr Res 42 1997 489 491
    • (1997) Pediatr Res , vol.42 , pp. 489-491
    • Dahlquist, G.1    Kallen, B.2
  • 26
    • 0026348377 scopus 로고
    • Effect of diabetes mellitus on mouse pre-implantation embryo development
    • K.H. Moley, W.K. Vaughn, A.H. DeCherney, M.P. Diamond Effect of diabetes mellitus on mouse pre-implantation embryo development J Reprod Fertil 93 1991 325 332
    • (1991) J Reprod Fertil , vol.93 , pp. 325-332
    • Moley, K.H.1    Vaughn, W.K.2    Decherney, A.H.3    Diamond, M.P.4
  • 27
    • 0022063035 scopus 로고
    • An experimental model for studies of fetal maldevelopment in the diabetic pregnancy
    • J.W. Kemnitz, R.H. Perelman, M.J. Engle, P.M. Farrell An experimental model for studies of fetal maldevelopment in the diabetic pregnancy Pediatr Pulmonol 1 1985 S79 S85
    • (1985) Pediatr Pulmonol , vol.1
    • Kemnitz, J.W.1    Perelman, R.H.2    Engle, M.J.3    Farrell, P.M.4
  • 28
    • 0022922292 scopus 로고
    • Effects of streptozotocin-induced diabetes on fetal development of the rat
    • E. Giavini, M.L. Broccia, M. Prati, G.D. Roversi, C. Vismara Effects of streptozotocin-induced diabetes on fetal development of the rat Teratology 34 1986 81 88
    • (1986) Teratology , vol.34 , pp. 81-88
    • Giavini, E.1    Broccia, M.L.2    Prati, M.3    Roversi, G.D.4    Vismara, C.5
  • 29
    • 0023709314 scopus 로고
    • Effect of streptozotocin administration to pregnant mice on serum glucose, glycosylated hemoglobin and weight of organs of the mother mice and their pups
    • E. Fujii, T. Nomoto Effect of streptozotocin administration to pregnant mice on serum glucose, glycosylated hemoglobin and weight of organs of the mother mice and their pups Jpn J Pharmacol 48 1988 391 394
    • (1988) Jpn J Pharmacol , vol.48 , pp. 391-394
    • Fujii, E.1    Nomoto, T.2
  • 30
    • 0023681612 scopus 로고
    • Diabetic embryopathy and fuel-mediated organ teratogenesis: Lessons from animal models
    • N. Freinkel Diabetic embryopathy and fuel-mediated organ teratogenesis Lessons from animal models Horm Metab Res 20 1988 463 475
    • (1988) Horm Metab Res , vol.20 , pp. 463-475
    • Freinkel, N.1
  • 31
    • 0036898999 scopus 로고    scopus 로고
    • Genotoxicity of streptozotocin
    • A.D. Bolzan, M.S. Bianchi Genotoxicity of streptozotocin Mutat Res 512 2002 121 134
    • (2002) Mutat Res , vol.512 , pp. 121-134
    • Bolzan, A.D.1    Bianchi, M.S.2
  • 32
    • 73649197648 scopus 로고
    • Studies on the diabetogenic action of streptozotocin (NSC-37917)
    • N. Rakieten, M.L. Rakieten, M.R. Nadkarni Studies on the diabetogenic action of streptozotocin (NSC-37917) Cancer Chemother Rep 29 1963 91 98
    • (1963) Cancer Chemother Rep , vol.29 , pp. 91-98
    • Rakieten, N.1    Rakieten, M.L.2    Nadkarni, M.R.3
  • 34
    • 0035082699 scopus 로고    scopus 로고
    • Localization of extracellular matrix and mitogen-activated protein kinase (MAPK) in aorta of streptozotocin treated Mongolian gerbils
    • Z. Naito, R. Nishigaki, K. Kawahara Localization of extracellular matrix and mitogen-activated protein kinase (MAPK) in aorta of streptozotocin treated Mongolian gerbils J Nippon Med Sch 68 2001 37 44
    • (2001) J Nippon Med Sch , vol.68 , pp. 37-44
    • Naito, Z.1    Nishigaki, R.2    Kawahara, K.3
  • 35
    • 0036724696 scopus 로고    scopus 로고
    • Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy
    • Y. Hiramatsu, N. Sekiguchi, M. Hayashi Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy Diabetes 51 2002 2804 2810
    • (2002) Diabetes , vol.51 , pp. 2804-2810
    • Hiramatsu, Y.1    Sekiguchi, N.2    Hayashi, M.3
  • 36
    • 0032999922 scopus 로고    scopus 로고
    • Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment
    • P. Wentzel, N. Welsh, U.J. Eriksson Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment Diabetes 48 1999 813 820
    • (1999) Diabetes , vol.48 , pp. 813-820
    • Wentzel, P.1    Welsh, N.2    Eriksson, U.J.3
  • 37
    • 0031030575 scopus 로고    scopus 로고
    • Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose
    • X. Yang, L.A. Borg, U.J. Eriksson Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose Am J Physiol 272 1997 E173 E180
    • (1997) Am J Physiol , vol.272
    • Yang, X.1    Borg, L.A.2    Eriksson, U.J.3
  • 38
    • 0029859125 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acid prevents malformations in offspring of diabetic rats
    • E.A. Reece, Y.K. Wu, A. Wiznitzer Dietary polyunsaturated fatty acid prevents malformations in offspring of diabetic rats Am J Obstet Gynecol 175 1996 818 823
    • (1996) Am J Obstet Gynecol , vol.175 , pp. 818-823
    • Reece, E.A.1    Wu, Y.K.2    Wiznitzer, A.3
  • 39
    • 0036022662 scopus 로고    scopus 로고
    • Aberrant patterns of cellular communication in diabetes-induced embryopathy. I. Membrane signalling
    • E.A. Reece, X.D. Ma, Y.K. Wu, D. Dhanasekaran Aberrant patterns of cellular communication in diabetes-induced embryopathy. I. Membrane signalling J Matern Fetal Neonatal Med 11 2002 249 253
    • (2002) J Matern Fetal Neonatal Med , vol.11 , pp. 249-253
    • Reece, E.A.1    Ma, X.D.2    Wu, Y.K.3    Dhanasekaran, D.4
  • 40
    • 0037955858 scopus 로고    scopus 로고
    • Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects
    • T.I. Chang, M. Horal, S.K. Jain, F. Wang, R. Patel, M.R. Loeken Oxidant regulation of gene expression and neural tube development Insights gained from diabetic pregnancy on molecular causes of neural tube defects Diabetologia 46 2003 538 545
    • (2003) Diabetologia , vol.46 , pp. 538-545
    • Chang, T.I.1    Horal, M.2    Jain, S.K.3    Wang, F.4    Patel, R.5    Loeken, M.R.6
  • 41
    • 0034059166 scopus 로고    scopus 로고
    • Malformations in offspring of diabetic rats: Morphometric analysis of neural crest-derived organs and effects of maternal vitamin e treatment
    • C.M. Siman, A.C. Gittenberger-De Groot, B. Wisse, U.J. Eriksson Malformations in offspring of diabetic rats morphometric analysis of neural crest-derived organs and effects of maternal vitamin E treatment Teratology 61 2000 355 367
    • (2000) Teratology , vol.61 , pp. 355-367
    • Siman, C.M.1    Gittenberger-De Groot, A.C.2    Wisse, B.3    Eriksson, U.J.4
  • 42
    • 0031424896 scopus 로고    scopus 로고
    • Free radical scavenging enzymes in fetal dysmorphogenesis among offspring of diabetic rats
    • E. Sivan, Y.C. Lee, Y.K. Wu, E.A. Reece Free radical scavenging enzymes in fetal dysmorphogenesis among offspring of diabetic rats Teratology 56 1997 343 349
    • (1997) Teratology , vol.56 , pp. 343-349
    • Sivan, E.1    Lee, Y.C.2    Wu, Y.K.3    Reece, E.A.4
  • 43
    • 0029971243 scopus 로고    scopus 로고
    • Synchronization of the factors critical for diabetic teratogenesis: An in vitro model
    • E.A. Reece, A. Wiznitzer, C.J. Homko, Z. Hagay, Y.K. Wu Synchronization of the factors critical for diabetic teratogenesis an in vitro model Am J Obstet Gynecol 174 1996 1284 1288
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 1284-1288
    • Reece, E.A.1    Wiznitzer, A.2    Homko, C.J.3    Hagay, Z.4    Wu, Y.K.5
  • 45
    • 0027487074 scopus 로고
    • Isolation and culture of whole postimplantation embryos and germ layer derivatives
    • K. Sturm, P.P. Tam Isolation and culture of whole postimplantation embryos and germ layer derivatives Methods Enzymol 225 1993 164 190
    • (1993) Methods Enzymol , vol.225 , pp. 164-190
    • Sturm, K.1    Tam, P.P.2
  • 46
    • 0035001058 scopus 로고    scopus 로고
    • Inhibition of cell proliferation in the embryonic myocardium by A1 adenosine receptor activation
    • Z. Zhao, S.A. Rivkees Inhibition of cell proliferation in the embryonic myocardium by A1 adenosine receptor activation Dev Dyn 221 2001 194 200
    • (2001) Dev Dyn , vol.221 , pp. 194-200
    • Zhao, Z.1    Rivkees, S.A.2
  • 47
    • 0037217745 scopus 로고    scopus 로고
    • Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation
    • Z. Zhao, S.A. Rivkees Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation Dev Dyn 226 2003 24 32
    • (2003) Dev Dyn , vol.226 , pp. 24-32
    • Zhao, Z.1    Rivkees, S.A.2
  • 48
    • 0024468905 scopus 로고
    • Yolk sac failure in embryopathy due to hyperglycemia: Horseradish peroxidase uptake in the assessment of yolk sac function
    • E.A. Reece, E. Pinter, C. Leranth, J.C. Hobbins, M.J. Mahoney, F. Naftolin Yolk sac failure in embryopathy due to hyperglycemia Horseradish peroxidase uptake in the assessment of yolk sac function Obstet Gynecol 74 1989 755 762
    • (1989) Obstet Gynecol , vol.74 , pp. 755-762
    • Reece, E.A.1    Pinter, E.2    Leranth, C.3    Hobbins, J.C.4    Mahoney, M.J.5    Naftolin, F.6
  • 49
    • 0022349886 scopus 로고
    • Ultrastructural analysis of malformations of the embryonic neural axis induced by in vitro hyperglycemic conditions
    • E.A. Reece, E. Pinter, C.Z. Leranth Ultrastructural analysis of malformations of the embryonic neural axis induced by in vitro hyperglycemic conditions Teratology 32 1985 363 373
    • (1985) Teratology , vol.32 , pp. 363-373
    • Reece, E.A.1    Pinter, E.2    Leranth, C.Z.3
  • 50
    • 0022578670 scopus 로고
    • Yolk sac failure in embryopathy due to hyperglycemia: Ultrastructural analysis of yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic conditions
    • E. Pinter, E.A. Reece, C.Z. Leranth Yolk sac failure in embryopathy due to hyperglycemia Ultrastructural analysis of yolk sac differentiation associated with embryopathy in rat conceptuses under hyperglycemic conditions Teratology 33 1986 73 84
    • (1986) Teratology , vol.33 , pp. 73-84
    • Pinter, E.1    Reece, E.A.2    Leranth, C.Z.3
  • 51
    • 0025868649 scopus 로고
    • Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro
    • U.J. Eriksson, L.A. Borg Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro Diabetologia 34 1991 325 331
    • (1991) Diabetologia , vol.34 , pp. 325-331
    • Eriksson, U.J.1    Borg, L.A.2
  • 52
    • 0026478723 scopus 로고
    • Development of rat embryos in culture media containing different concentrations of normal and diabetic rat serum
    • J. Styrud, U.J. Eriksson Development of rat embryos in culture media containing different concentrations of normal and diabetic rat serum Teratology 46 1992 473 483
    • (1992) Teratology , vol.46 , pp. 473-483
    • Styrud, J.1    Eriksson, U.J.2
  • 53
    • 0029863939 scopus 로고    scopus 로고
    • High glucose concentration inhibits migration of rat cranial neural crest cells in vitro
    • N. Suzuki, K. Svensson, U.J. Eriksson High glucose concentration inhibits migration of rat cranial neural crest cells in vitro Diabetologia 39 1996 401 411
    • (1996) Diabetologia , vol.39 , pp. 401-411
    • Suzuki, N.1    Svensson, K.2    Eriksson, U.J.3
  • 54
    • 0031945983 scopus 로고    scopus 로고
    • Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro
    • P. Wentzel, U.J. Eriksson Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro Diabetes 47 1998 677 684
    • (1998) Diabetes , vol.47 , pp. 677-684
    • Wentzel, P.1    Eriksson, U.J.2
  • 55
    • 0035001764 scopus 로고    scopus 로고
    • Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity
    • P. Wentzel, C.R. Wentzel, M.B. Gareskog, U.J. Eriksson Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity Teratology 63 2001 193 201
    • (2001) Teratology , vol.63 , pp. 193-201
    • Wentzel, P.1    Wentzel, C.R.2    Gareskog, M.B.3    Eriksson, U.J.4
  • 56
    • 0346335999 scopus 로고    scopus 로고
    • Renal development in high-glucose ambience and diabetic embryopathy
    • S.S. Chugh, E.I. Wallner, Y.S. Kanwar Renal development in high-glucose ambience and diabetic embryopathy Semin Nephrol 23 2003 583 592
    • (2003) Semin Nephrol , vol.23 , pp. 583-592
    • Chugh, S.S.1    Wallner, E.I.2    Kanwar, Y.S.3
  • 57
    • 0020419159 scopus 로고
    • Association of bilateral renal agenesis and di George syndrome in an infant of a diabetic mother
    • S. Gosseye, M.C. Golaire, G. Verellen, M. Van Lierde, D. Claus Association of bilateral renal agenesis and Di George syndrome in an infant of a diabetic mother Helv Paediatr Acta 37 1982 471 474
    • (1982) Helv Paediatr Acta , vol.37 , pp. 471-474
    • Gosseye, S.1    Golaire, M.C.2    Verellen, G.3    Van Lierde, M.4    Claus, D.5
  • 58
    • 0742271057 scopus 로고    scopus 로고
    • Lumbosacral agenesis in a premature infant of a diabetic mother
    • M.C. Lee, P.J. Wang, R.L. Chen Lumbosacral agenesis in a premature infant of a diabetic mother Acta Paediatr Taiwan 44 2003 375 378
    • (2003) Acta Paediatr Taiwan , vol.44 , pp. 375-378
    • Lee, M.C.1    Wang, P.J.2    Chen, R.L.3
  • 59
    • 0021835883 scopus 로고
    • Maturation of fetal rat lung in diabetic pregnancies of graduated severity
    • J.R. Bourbon, B. Pignol, L. Marin, M. Rieutort, C. Tordet Maturation of fetal rat lung in diabetic pregnancies of graduated severity Diabetes 34 1985 734 743
    • (1985) Diabetes , vol.34 , pp. 734-743
    • Bourbon, J.R.1    Pignol, B.2    Marin, L.3    Rieutort, M.4    Tordet, C.5
  • 62
    • 0030994305 scopus 로고    scopus 로고
    • Neural tube defects in embryos of diabetic mice: Role of the Pax-3 gene and apoptosis
    • S.A. Phelan, M. Ito, M.R. Loeken Neural tube defects in embryos of diabetic mice role of the Pax-3 gene and apoptosis Diabetes 46 1997 1189 1197
    • (1997) Diabetes , vol.46 , pp. 1189-1197
    • Phelan, S.A.1    Ito, M.2    Loeken, M.R.3
  • 63
    • 0031728455 scopus 로고    scopus 로고
    • Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways
    • K.H. Moley, M.M. Chi, C.M. Knudson, S.J. Korsmeyer, M.M. Mueckler Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways Nat Med 4 1998 1421 1424
    • (1998) Nat Med , vol.4 , pp. 1421-1424
    • Moley, K.H.1    Chi, M.M.2    Knudson, C.M.3    Korsmeyer, S.J.4    Mueckler, M.M.5
  • 64
    • 0034842413 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptotic cell death in the mouse blastocyst is dependent on expression of p53
    • A.L. Keim, M.M. Chi, K.H. Moley Hyperglycemia-induced apoptotic cell death in the mouse blastocyst is dependent on expression of p53 Mol Reprod Dev 60 2001 214 224
    • (2001) Mol Reprod Dev , vol.60 , pp. 214-224
    • Keim, A.L.1    Chi, M.M.2    Moley, K.H.3
  • 65
    • 0031859217 scopus 로고    scopus 로고
    • Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos
    • K.H. Moley, M.M. Chi, M.M. Mueckler Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos Am J Physiol 275 1998 E38 E47
    • (1998) Am J Physiol , vol.275
    • Moley, K.H.1    Chi, M.M.2    Mueckler, M.M.3
  • 66
    • 0347994902 scopus 로고    scopus 로고
    • Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy
    • C.W. Heilig, T. Saunders, F.C. Brosius 3rd Glucose transporter-1- deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy Proc Natl Acad Sci U S A 100 2003 15613 15618
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 15613-15618
    • Heilig, C.W.1    Saunders, T.2    Brosius III, F.C.3
  • 67
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • S. Cory, D.C. Huang, J.M. Adams The Bcl-2 family Roles in cell survival and oncogenesis Oncogene 22 2003 8590 8607
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 68
    • 0242500356 scopus 로고    scopus 로고
    • Identification of caspase-6 in rat blastocysts and its implication in the induction of apoptosis by high glucose
    • L. Hinck, J.P. Thissen, R. De Hertogh Identification of caspase-6 in rat blastocysts and its implication in the induction of apoptosis by high glucose Biol Reprod 68 2003 1808 1812
    • (2003) Biol Reprod , vol.68 , pp. 1808-1812
    • Hinck, L.1    Thissen, J.P.2    De Hertogh, R.3
  • 69
    • 0033513480 scopus 로고    scopus 로고
    • Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy
    • E.L. Fine, M. Horal, T.I. Chang, G. Fortin, M.R. Loeken Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy Diabetes 48 1999 2454 2462
    • (1999) Diabetes , vol.48 , pp. 2454-2462
    • Fine, E.L.1    Horal, M.2    Chang, T.I.3    Fortin, G.4    Loeken, M.R.5
  • 70
    • 0037398980 scopus 로고    scopus 로고
    • Increased TNF-alpha expression in cultured mouse embryos exposed to teratogenic concentrations of glucose
    • A. Torchinsky, I. Brokhman, J. Shepshelovich Increased TNF-alpha expression in cultured mouse embryos exposed to teratogenic concentrations of glucose Reproduction 125 2003 527 534
    • (2003) Reproduction , vol.125 , pp. 527-534
    • Torchinsky, A.1    Brokhman, I.2    Shepshelovich, J.3
  • 71
    • 0028125791 scopus 로고
    • Cellular-tissue localization and regulation of the GLUT-1 protein in both the embryo and the visceral yolk sac from normal and experimental diabetic rats during the early postimplantation period
    • R.A. Trocino, S. Akazawa, H. Takino Cellular-tissue localization and regulation of the GLUT-1 protein in both the embryo and the visceral yolk sac from normal and experimental diabetic rats during the early postimplantation period Endocrinology 134 1994 869 878
    • (1994) Endocrinology , vol.134 , pp. 869-878
    • Trocino, R.A.1    Akazawa, S.2    Takino, H.3
  • 72
    • 0031239122 scopus 로고    scopus 로고
    • Pax genes and organogenesis
    • E. Dahl, H. Koseki, R. Balling Pax genes and organogenesis Bioessays 19 1997 755 765
    • (1997) Bioessays , vol.19 , pp. 755-765
    • Dahl, E.1    Koseki, H.2    Balling, R.3
  • 73
    • 0033168934 scopus 로고    scopus 로고
    • Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp2H) mutant: Putative roles for Pax3 and PDGFRalpha in rib patterning
    • E.D. Dickman, R. Rogers, S.J. Conway Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp2H) mutant putative roles for Pax3 and PDGFRalpha in rib patterning Anat Rec 255 1999 353 361
    • (1999) Anat Rec , vol.255 , pp. 353-361
    • Dickman, E.D.1    Rogers, R.2    Conway, S.J.3
  • 74
    • 0037087629 scopus 로고    scopus 로고
    • Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: Implications for Pax-3- dependent development and tumorigenesis
    • L. Pani, M. Horal, M.R. Loeken Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function Implications for Pax-3- dependent development and tumorigenesis Genes Dev 16 2002 676 680
    • (2002) Genes Dev , vol.16 , pp. 676-680
    • Pani, L.1    Horal, M.2    Loeken, M.R.3
  • 75
    • 0036723777 scopus 로고    scopus 로고
    • Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy
    • L. Pani, M. Horal, M.R. Loeken Polymorphic susceptibility to the molecular causes of neural tube defects during diabetic embryopathy Diabetes 51 2002 2871 2874
    • (2002) Diabetes , vol.51 , pp. 2871-2874
    • Pani, L.1    Horal, M.2    Loeken, M.R.3
  • 77
    • 0028366664 scopus 로고
    • The yolk sac theory: Closing the circle on why diabetes-associated malformations occur
    • E.A. Reece, E. Pinter, C. Homko, Y.K. Wu, F. Naftolin The yolk sac theory Closing the circle on why diabetes-associated malformations occur J Soc Gynecol Investig 1 1994 3 13
    • (1994) J Soc Gynecol Investig , vol.1 , pp. 3-13
    • Reece, E.A.1    Pinter, E.2    Homko, C.3    Wu, Y.K.4    Naftolin, F.5
  • 78
    • 0023009044 scopus 로고
    • Arachidonic acid prevents hyperglycemia-associated yolk sac damage and embryopathy
    • E. Pinter, E.A. Reece, C.Z. Leranth Arachidonic acid prevents hyperglycemia-associated yolk sac damage and embryopathy Am J Obstet.Gynecol 155 1986 691 702
    • (1986) Am J Obstet.Gynecol , vol.155 , pp. 691-702
    • Pinter, E.1    Reece, E.A.2    Leranth, C.Z.3
  • 79
    • 0025318323 scopus 로고
    • Development, morphology, and function of the yolk-sac placenta of laboratory rodents
    • W.P. Jollie Development, morphology, and function of the yolk-sac placenta of laboratory rodents Teratology 41 1990 361 381
    • (1990) Teratology , vol.41 , pp. 361-381
    • Jollie, W.P.1
  • 80
    • 0024510985 scopus 로고
    • Role of the mouse visceral yolk sac in nutrition: Inhibition by a somatomedin inhibitor
    • W. Balkan, L.S. Phillips, S. Goldstein, T.W. Sadler Role of the mouse visceral yolk sac in nutrition Inhibition by a somatomedin inhibitor J Exp Zool 249 1989 36 40
    • (1989) J Exp Zool , vol.249 , pp. 36-40
    • Balkan, W.1    Phillips, L.S.2    Goldstein, S.3    Sadler, T.W.4
  • 81
    • 0015104888 scopus 로고
    • The production of congenital malformations using tissue antisera. VII. Yolk-sac antiserum
    • R.L. Brent, A.J. Johnson, M. Jensen The production of congenital malformations using tissue antisera. VII. Yolk-sac antiserum Teratology 4 1971 255 275
    • (1971) Teratology , vol.4 , pp. 255-275
    • Brent, R.L.1    Johnson, A.J.2    Jensen, M.3
  • 82
    • 0019731686 scopus 로고
    • The role of the visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro
    • S.J. Freeman, F. Beck, J.B. Lloyd The role of the visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro J Embryol.Exp.Morphol 66 1981 223 234
    • (1981) J Embryol.Exp.Morphol , vol.66 , pp. 223-234
    • Freeman, S.J.1    Beck, F.2    Lloyd, J.B.3
  • 83
    • 14644442313 scopus 로고    scopus 로고
    • Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats: II, apoptotic pathways
    • E.A. Reece, X.-D. Ma, Z. Zhao, Y.-K. Wu, D. Dhanasekaran Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats II, apoptotic pathways Am J Obstet Gynecol 192 2005 967
    • (2005) Am J Obstet Gynecol , vol.192 , pp. 967
    • Reece, E.A.1    Ma, X.-D.2    Zhao, Z.3    Wu, Y.-K.4    Dhanasekaran, D.5
  • 84
    • 0032908445 scopus 로고    scopus 로고
    • Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: Correlation with PECAM-1/CD31 tyrosine phosphorylation state
    • E. Pinter, S. Mahooti, Y. Wang, B.A. Imhof, J.A. Madri Hyperglycemia-induced vasculopathy in the murine vitelline vasculature Correlation with PECAM-1/CD31 tyrosine phosphorylation state Am J Pathol 154 1999 1367 1379
    • (1999) Am J Pathol , vol.154 , pp. 1367-1379
    • Pinter, E.1    Mahooti, S.2    Wang, Y.3    Imhof, B.A.4    Madri, J.A.5
  • 85
    • 3042758484 scopus 로고    scopus 로고
    • Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy
    • A.K. Nath, J. Enciso, M. Kuniyasu, X.Y. Hao, J.A. Madri, E. Pinter Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy Development 131 2004 2485 2496
    • (2004) Development , vol.131 , pp. 2485-2496
    • Nath, A.K.1    Enciso, J.2    Kuniyasu, M.3    Hao, X.Y.4    Madri, J.A.5    Pinter, E.6
  • 86
    • 0031874953 scopus 로고    scopus 로고
    • The role of free radicals and membrane lipids in diabetes-induced congenital malformations
    • E.A. Reece, C.J. Homko, Y.K. Wu, A. Wiznitzer The role of free radicals and membrane lipids in diabetes-induced congenital malformations J Soc Gynecol Investig 5 1998 178 187
    • (1998) J Soc Gynecol Investig , vol.5 , pp. 178-187
    • Reece, E.A.1    Homko, C.J.2    Wu, Y.K.3    Wiznitzer, A.4
  • 87
    • 0034855696 scopus 로고    scopus 로고
    • Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy
    • J. Cederberg, S. Basu, U.J. Eriksson Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy Diabetologia 44 2001 766 774
    • (2001) Diabetologia , vol.44 , pp. 766-774
    • Cederberg, J.1    Basu, S.2    Eriksson, U.J.3
  • 88
    • 0031425104 scopus 로고    scopus 로고
    • Decreased catalase activity in malformation-prone embryos of diabetic rats
    • J. Cederberg, U.J. Eriksson Decreased catalase activity in malformation-prone embryos of diabetic rats Teratology 56 1997 350 357
    • (1997) Teratology , vol.56 , pp. 350-357
    • Cederberg, J.1    Eriksson, U.J.2
  • 89
    • 0029896116 scopus 로고    scopus 로고
    • Altered levels of scavenging enzymes in embryos subjected to a diabetic environment
    • H. Forsberg, L.A. Borg, E. Cagliero, U.J. Eriksson Altered levels of scavenging enzymes in embryos subjected to a diabetic environment Free Radic Res 24 1996 451 459
    • (1996) Free Radic Res , vol.24 , pp. 451-459
    • Forsberg, H.1    Borg, L.A.2    Cagliero, E.3    Eriksson, U.J.4
  • 91
    • 0032938778 scopus 로고    scopus 로고
    • Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations
    • H. Sakamaki, S. Akazawa, M. Ishibashi Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations Diabetes 48 1999 1138 1144
    • (1999) Diabetes , vol.48 , pp. 1138-1144
    • Sakamaki, H.1    Akazawa, S.2    Ishibashi, M.3
  • 92
    • 0029150524 scopus 로고
    • Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture
    • R.A. Trocino, S. Akazawa, M. Ishibashi Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture Diabetes 44 1995 992 998
    • (1995) Diabetes , vol.44 , pp. 992-998
    • Trocino, R.A.1    Akazawa, S.2    Ishibashi, M.3
  • 93
    • 0034952067 scopus 로고    scopus 로고
    • Vitamins C and e improve rat embryonic antioxidant defense mechanism in diabetic culture medium
    • V. Zaken, R. Kohen, A. Ornoy Vitamins C and E improve rat embryonic antioxidant defense mechanism in diabetic culture medium Teratology 64 2001 33 44
    • (2001) Teratology , vol.64 , pp. 33-44
    • Zaken, V.1    Kohen, R.2    Ornoy, A.3
  • 94
    • 0034987977 scopus 로고    scopus 로고
    • Combined treatment with vitamin e and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy
    • J. Cederberg, C.M. Siman, U.J. Eriksson Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy Pediatr Res 49 2001 755 762
    • (2001) Pediatr Res , vol.49 , pp. 755-762
    • Cederberg, J.1    Siman, C.M.2    Eriksson, U.J.3
  • 95
    • 0031026171 scopus 로고    scopus 로고
    • Oxygen-induced embryopathy and the significance of glutathione-dependent antioxidant system in the rat embryo during early organogenesis
    • M. Ishibashi, S. Akazawa, H. Sakamaki Oxygen-induced embryopathy and the significance of glutathione-dependent antioxidant system in the rat embryo during early organogenesis Free Radic Biol Med 22 1997 447 454
    • (1997) Free Radic Biol Med , vol.22 , pp. 447-454
    • Ishibashi, M.1    Akazawa, S.2    Sakamaki, H.3
  • 96
    • 0030925475 scopus 로고    scopus 로고
    • Prevention of diabetic embryopathy in offspring of diabetic rats with use of a cocktail of deficient substrates and an antioxidant
    • E.A. Reece, Y.K. Wu Prevention of diabetic embryopathy in offspring of diabetic rats with use of a cocktail of deficient substrates and an antioxidant Am J Obstet Gynecol 176 1997 790 797
    • (1997) Am J Obstet Gynecol , vol.176 , pp. 790-797
    • Reece, E.A.1    Wu, Y.K.2
  • 97
    • 0030988703 scopus 로고    scopus 로고
    • Vitamin e decreases the occurrence of malformations in the offspring of diabetic rats
    • C.M. Siman, U.J. Eriksson Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats Diabetes 46 1997 1054 1061
    • (1997) Diabetes , vol.46 , pp. 1054-1061
    • Siman, C.M.1    Eriksson, U.J.2
  • 98
    • 0031452090 scopus 로고    scopus 로고
    • Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats
    • C.M. Siman, U.J. Eriksson Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats Diabetologia 40 1997 1416 1424
    • (1997) Diabetologia , vol.40 , pp. 1416-1424
    • Siman, C.M.1    Eriksson, U.J.2
  • 99
    • 0029979698 scopus 로고    scopus 로고
    • Dietary vitamin e prophylaxis and diabetic embryopathy: Morphologic and biochemical analysis
    • E. Sivan, E.A. Reece, Y.K. Wu, C.J. Homko, M. Polansky, M. Borenstein Dietary vitamin E prophylaxis and diabetic embryopathy Morphologic and biochemical analysis Am J Obstet Gynecol 175 1996 793 799
    • (1996) Am J Obstet Gynecol , vol.175 , pp. 793-799
    • Sivan, E.1    Reece, E.A.2    Wu, Y.K.3    Homko, C.J.4    Polansky, M.5    Borenstein, M.6
  • 100
    • 0037217430 scopus 로고    scopus 로고
    • Effect of different doses of vitamin e on the incidence of malformations in pregnant diabetic rats
    • M. Viana, M. Castro, C. Barbas, E. Herrera, B. Bonet Effect of different doses of vitamin E on the incidence of malformations in pregnant diabetic rats Ann Nutr Metab 47 2003 6 10
    • (2003) Ann Nutr Metab , vol.47 , pp. 6-10
    • Viana, M.1    Castro, M.2    Barbas, C.3    Herrera, E.4    Bonet, B.5
  • 101
    • 0033024482 scopus 로고    scopus 로고
    • Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes
    • A. Wiznitzer, N. Ayalon, R. Hershkovitz Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes Am J Obstet Gynecol 180 1999 188 193
    • (1999) Am J Obstet Gynecol , vol.180 , pp. 188-193
    • Wiznitzer, A.1    Ayalon, N.2    Hershkovitz, R.3
  • 102
    • 0034951169 scopus 로고    scopus 로고
    • Mitochondria, oxygen free radicals, and apoptosis
    • S. Raha, B.H. Robinson Mitochondria, oxygen free radicals, and apoptosis Am J Med Genet 106 2001 62 70
    • (2001) Am J Med Genet , vol.106 , pp. 62-70
    • Raha, S.1    Robinson, B.H.2
  • 103
    • 0028899554 scopus 로고
    • Altered mitochondrial morphology of rat embryos in diabetic pregnancy
    • X. Yang, L.A. Borg, U.J. Eriksson Altered mitochondrial morphology of rat embryos in diabetic pregnancy Anat Rec 241 1995 255 267
    • (1995) Anat Rec , vol.241 , pp. 255-267
    • Yang, X.1    Borg, L.A.2    Eriksson, U.J.3
  • 104
    • 0031860943 scopus 로고    scopus 로고
    • Maternal antioxidant treatments prevent diabetes-induced alterations of mitochondrial morphology in rat embryos
    • X. Yang, L.A. Borg, C.M. Siman, U.J. Eriksson Maternal antioxidant treatments prevent diabetes-induced alterations of mitochondrial morphology in rat embryos Anat Rec 251 1998 303 315
    • (1998) Anat Rec , vol.251 , pp. 303-315
    • Yang, X.1    Borg, L.A.2    Siman, C.M.3    Eriksson, U.J.4
  • 105
    • 0038544351 scopus 로고    scopus 로고
    • Regulatory functions of prostaglandin E2 synthases
    • I. Kudo, M. Murakami Regulatory functions of prostaglandin E2 synthases Adv Exp Med Biol 525 2003 103 106
    • (2003) Adv Exp Med Biol , vol.525 , pp. 103-106
    • Kudo, I.1    Murakami, M.2
  • 106
    • 0141538107 scopus 로고    scopus 로고
    • Cyclooxygenase-2 biology
    • J. Claria Cyclooxygenase-2 biology Curr Pharm Des 9 2003 2177 2190
    • (2003) Curr Pharm des , vol.9 , pp. 2177-2190
    • Claria, J.1
  • 107
    • 0025572704 scopus 로고
    • A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism
    • J.D. Morrow, K.E. Hill, R.F. Burk, T.M. Nammour, K.F. Badr, L.J. Roberts A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proc Natl.Acad.Sci U.S.A 87 1990 9383 9387
    • (1990) Proc Natl.Acad.Sci U.S.A , vol.87 , pp. 9383-9387
    • Morrow, J.D.1    Hill, K.E.2    Burk, R.F.3    Nammour, T.M.4    Badr, K.F.5    Roberts, L.J.6
  • 108
    • 0034543797 scopus 로고    scopus 로고
    • The isoprostanes: Their quantification as an index of oxidant stress status in vivo
    • J.D. Morrow The isoprostanes Their quantification as an index of oxidant stress status in vivo Drug Metab Rev 32 2000 377 385
    • (2000) Drug Metab Rev , vol.32 , pp. 377-385
    • Morrow, J.D.1
  • 109
    • 0030005412 scopus 로고    scopus 로고
    • Diabetes mellitus affects prostaglandin E2 levels in mouse embryos during neurulation
    • R. Piddington, J. Joyce, P. Dhanasekaran, L. Baker Diabetes mellitus affects prostaglandin E2 levels in mouse embryos during neurulation Diabetologia 39 1996 915 920
    • (1996) Diabetologia , vol.39 , pp. 915-920
    • Piddington, R.1    Joyce, J.2    Dhanasekaran, P.3    Baker, L.4
  • 110
    • 0344170888 scopus 로고
    • Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid
    • A.S. Goldman, L. Baker, R. Piddington, B. Marx, R. Herold, J. Egler Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid Proc Natl Acad Sci U S A 82 1985 8227 8231
    • (1985) Proc Natl Acad Sci U S a , vol.82 , pp. 8227-8231
    • Goldman, A.S.1    Baker, L.2    Piddington, R.3    Marx, B.4    Herold, R.5    Egler, J.6
  • 111
    • 0029859125 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acid prevents malformations in offspring of diabetic rats
    • E.A. Reece, Y.K. Wu, A. Wiznitzer Dietary polyunsaturated fatty acid prevents malformations in offspring of diabetic rats Am J Obstet.Gynecol 175 1996 818 823
    • (1996) Am J Obstet.Gynecol , vol.175 , pp. 818-823
    • Reece, E.A.1    Wu, Y.K.2    Wiznitzer, A.3
  • 112
    • 0026615225 scopus 로고
    • PGE2 prevents anomalies induced by hyperglycemia or diabetic serum in mouse embryos
    • M.P. Goto, A.S. Goldman, M.R. Uhing PGE2 prevents anomalies induced by hyperglycemia or diabetic serum in mouse embryos Diabetes 41 1992 1644 1650
    • (1992) Diabetes , vol.41 , pp. 1644-1650
    • Goto, M.P.1    Goldman, A.S.2    Uhing, M.R.3
  • 113
    • 0026339326 scopus 로고
    • Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos
    • E. Engstrom, A. Haglund, U.J. Eriksson Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos Pediatr Res 30 1991 150 153
    • (1991) Pediatr Res , vol.30 , pp. 150-153
    • Engstrom, E.1    Haglund, A.2    Eriksson, U.J.3
  • 114
    • 0026615225 scopus 로고
    • PGE2 prevents anomalies induced by hyperglycemia or diabetic serum in mouse embryos
    • M.P. Goto, A.S. Goldman, M.R. Uhing PGE2 prevents anomalies induced by hyperglycemia or diabetic serum in mouse embryos Diabetes 41 1992 1644 1650
    • (1992) Diabetes , vol.41 , pp. 1644-1650
    • Goto, M.P.1    Goldman, A.S.2    Uhing, M.R.3
  • 115
    • 0037967476 scopus 로고    scopus 로고
    • Lipid metabolism in the embryos of diabetic rats during early organogenesis: Modulatory effect of prostaglandin E(2)
    • D. Sinner, J.M. Caviglia, A. Jawerbaum, R.A. Igal, E. Gonzalez Lipid metabolism in the embryos of diabetic rats during early organogenesis modulatory effect of prostaglandin E(2) Reprod Fertil Dev 15 2003 75 80
    • (2003) Reprod Fertil Dev , vol.15 , pp. 75-80
    • Sinner, D.1    Caviglia, J.M.2    Jawerbaum, A.3    Igal, R.A.4    Gonzalez, E.5
  • 117
    • 0032999922 scopus 로고    scopus 로고
    • Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment
    • P. Wentzel, N. Welsh, U.J. Eriksson Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment Diabetes 48 1999 813 820
    • (1999) Diabetes , vol.48 , pp. 813-820
    • Wentzel, P.1    Welsh, N.2    Eriksson, U.J.3
  • 118
    • 0028981697 scopus 로고
    • Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus
    • N.K. Gopaul, E.E. Anggard, A.I. Mallet, D.J. Betteridge, S.P. Wolff, J. Nourooz-Zadeh Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus FEBS Lett 368 1995 225 229
    • (1995) FEBS Lett , vol.368 , pp. 225-229
    • Gopaul, N.K.1    Anggard, E.E.2    Mallet, A.I.3    Betteridge, D.J.4    Wolff, S.P.5    Nourooz-Zadeh, J.6
  • 119
    • 0036799963 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. Prostaglandins Leukot
    • T. Decsi, H. Minda, R. Hermann Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. Prostaglandins Leukot Essent. Fatty Acids 67 2002 203 210
    • (2002) Essent. Fatty Acids , vol.67 , pp. 203-210
    • Decsi, T.1    Minda, H.2    Hermann, R.3
  • 120
    • 0036391413 scopus 로고    scopus 로고
    • 8-Iso-PGF(2alpha) administration generates dysmorphogenesis and increased lipid peroxidation in rat embryos in vitro
    • P. Wentzel, U.J. Eriksson 8-Iso-PGF(2alpha) administration generates dysmorphogenesis and increased lipid peroxidation in rat embryos in vitro Teratology 66 2002 164 168
    • (2002) Teratology , vol.66 , pp. 164-168
    • Wentzel, P.1    Eriksson, U.J.2
  • 122
    • 0036855827 scopus 로고    scopus 로고
    • Activation mechanisms of protein kinase C: Maturation, catalytic activation, and targeting
    • Y. Shirai, N. Saito Activation mechanisms of protein kinase C Maturation, catalytic activation, and targeting J Biochem (Tokyo) 132 2002 663 668
    • (2002) J Biochem (Tokyo) , vol.132 , pp. 663-668
    • Shirai, Y.1    Saito, N.2
  • 123
    • 0022978398 scopus 로고
    • Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: Failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis
    • M. Hod, S. Star, J.V. Passonneau, T.G. Unterman, N. Freinkel Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus Failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis Biochem Biophys Res.Commun 140 1986 974 980
    • (1986) Biochem Biophys Res.Commun , vol.140 , pp. 974-980
    • Hod, M.1    Star, S.2    Passonneau, J.V.3    Unterman, T.G.4    Freinkel, N.5
  • 124
    • 0024247097 scopus 로고
    • Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat
    • I. Sussman, F.M. Matschinsky Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat Diabetes 37 1988 974 981
    • (1988) Diabetes , vol.37 , pp. 974-981
    • Sussman, I.1    Matschinsky, F.M.2
  • 125
    • 0026327119 scopus 로고
    • Effects of insulin and myo-inositol on embryo growth and development during early organogenesis in streptozocin-induced diabetic rats
    • M. Akashi, S. Akazawa, M. Akazawa Effects of insulin and myo-inositol on embryo growth and development during early organogenesis in streptozocin-induced diabetic rats Diabetes 40 1991 1574 1579
    • (1991) Diabetes , vol.40 , pp. 1574-1579
    • Akashi, M.1    Akazawa, S.2    Akazawa, M.3
  • 126
    • 0025013924 scopus 로고
    • Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos
    • L. Baker, R. Piddington, A. Goldman, J. Egler, J. Moehring Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos Diabetologia 33 1990 593 596
    • (1990) Diabetologia , vol.33 , pp. 593-596
    • Baker, L.1    Piddington, R.2    Goldman, A.3    Egler, J.4    Moehring, J.5
  • 127
    • 0025695679 scopus 로고
    • Glucose-induced dysmorphogenesis in the cultured rat conceptus: Prevention by supplementation with myo-inositol
    • M. Hod, S. Star, J. Passonneau, T.G. Unterman, N. Freinkel Glucose-induced dysmorphogenesis in the cultured rat conceptus prevention by supplementation with myo-inositol Isr J Med Sci 26 1990 541 544
    • (1990) Isr J Med Sci , vol.26 , pp. 541-544
    • Hod, M.1    Star, S.2    Passonneau, J.3    Unterman, T.G.4    Freinkel, N.5
  • 128
    • 0031976447 scopus 로고    scopus 로고
    • Dietary myo-inositol therapy in hyperglycemia-induced embryopathy
    • M. Khandelwal, E.A. Reece, Y.K. Wu, M. Borenstein Dietary myo-inositol therapy in hyperglycemia-induced embryopathy Teratology 57 1998 79 84
    • (1998) Teratology , vol.57 , pp. 79-84
    • Khandelwal, M.1    Reece, E.A.2    Wu, Y.K.3    Borenstein, M.4
  • 129
    • 0030965042 scopus 로고    scopus 로고
    • Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats
    • E.A. Reece, M. Khandelwal, Y.K. Wu, M. Borenstein Dietary intake of myo-inositol and neural tube defects in offspring of diabetic rats Am J Obstet Gynecol 176 1997 536 539
    • (1997) Am J Obstet Gynecol , vol.176 , pp. 536-539
    • Reece, E.A.1    Khandelwal, M.2    Wu, Y.K.3    Borenstein, M.4
  • 130
    • 1042291963 scopus 로고    scopus 로고
    • The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy
    • T.M. Curtis, C.N. Scholfield The role of lipids and protein kinase Cs in the pathogenesis of diabetic retinopathy Diabetes Metab Res Rev 20 2004 28 43
    • (2004) Diabetes Metab Res Rev , vol.20 , pp. 28-43
    • Curtis, T.M.1    Scholfield, C.N.2
  • 131
    • 0036134050 scopus 로고    scopus 로고
    • High glucose-induced activation of protein kinase signaling pathways in vascular smooth muscle cells: A potential role in the pathogenesis of vascular dysfunction in diabetes (review)
    • A.K. Srivastava High glucose-induced activation of protein kinase signaling pathways in vascular smooth muscle cells A potential role in the pathogenesis of vascular dysfunction in diabetes (review) Int J Mol Med 9 2002 85 89
    • (2002) Int J Mol Med , vol.9 , pp. 85-89
    • Srivastava, A.K.1
  • 132
    • 0035669720 scopus 로고    scopus 로고
    • Protein kinase C and the development of diabetic vascular complications
    • K.J. Way, N. Katai, G.L. King Protein kinase C and the development of diabetic vascular complications Diabet Med 18 2001 945 959
    • (2001) Diabet Med , vol.18 , pp. 945-959
    • Way, K.J.1    Katai, N.2    King, G.L.3
  • 133
    • 0033949316 scopus 로고    scopus 로고
    • Induction of endothelin-1 expression by glucose: An effect of protein kinase C activation
    • J.Y. Park, N. Takahara, A. Gabriele Induction of endothelin-1 expression by glucose an effect of protein kinase C activation Diabetes 49 2000 1239 1248
    • (2000) Diabetes , vol.49 , pp. 1239-1248
    • Park, J.Y.1    Takahara, N.2    Gabriele, A.3
  • 134
    • 2342641505 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase signaling
    • S.V. Kyosseva Mitogen-activated protein kinase signaling Int Rev Neurobiol 59 2004 201 220
    • (2004) Int Rev Neurobiol , vol.59 , pp. 201-220
    • Kyosseva, S.V.1
  • 135
    • 0142043984 scopus 로고    scopus 로고
    • Redox signaling and the MAP kinase pathways
    • M. Torres, H.J. Forman Redox signaling and the MAP kinase pathways Biofactors 17 2003 287 296
    • (2003) Biofactors , vol.17 , pp. 287-296
    • Torres, M.1    Forman, H.J.2
  • 136
    • 2342562556 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in apoptosis regulation
    • T. Wada, J.M. Penninger Mitogen-activated protein kinases in apoptosis regulation Oncogene 23 2004 2838 2849
    • (2004) Oncogene , vol.23 , pp. 2838-2849
    • Wada, T.1    Penninger, J.M.2
  • 137
    • 0042734434 scopus 로고    scopus 로고
    • The true face of JNK activation in apoptosis
    • A. Lin, B. Dibling The true face of JNK activation in apoptosis Aging Cell 1 2002 112 116
    • (2002) Aging Cell , vol.1 , pp. 112-116
    • Lin, A.1    Dibling, B.2
  • 139
    • 0033024482 scopus 로고    scopus 로고
    • Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes
    • A. Wiznitzer, N. Ayalon, R. Hershkovitz Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes Am J Obstet Gynecol 180 1999 188 193
    • (1999) Am J Obstet Gynecol , vol.180 , pp. 188-193
    • Wiznitzer, A.1    Ayalon, N.2    Hershkovitz, R.3
  • 140
    • 0034773628 scopus 로고    scopus 로고
    • Molecular aspects of lipoic acid in the prevention of diabetes complications
    • L. Packer, K. Kraemer, G. Rimbach Molecular aspects of lipoic acid in the prevention of diabetes complications Nutrition 17 2001 888 895
    • (2001) Nutrition , vol.17 , pp. 888-895
    • Packer, L.1    Kraemer, K.2    Rimbach, G.3
  • 141
    • 0035037526 scopus 로고    scopus 로고
    • Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: An exploratory study
    • M. Morcos, V. Borcea, B. Isermann Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus An exploratory study Diabetes Res.Clin Pract 52 2001 175 183
    • (2001) Diabetes Res.Clin Pract , vol.52 , pp. 175-183
    • Morcos, M.1    Borcea, V.2    Isermann, B.3
  • 142
    • 0034987977 scopus 로고    scopus 로고
    • Combined treatment with vitamin e and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy
    • J. Cederberg, C.M. Siman, U.J. Eriksson Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy Pediatr Res 49 2001 755 762
    • (2001) Pediatr Res , vol.49 , pp. 755-762
    • Cederberg, J.1    Siman, C.M.2    Eriksson, U.J.3
  • 144
    • 0029979698 scopus 로고    scopus 로고
    • Dietary vitamin e prophylaxis and diabetic embryopathy: Morphologic and biochemical analysis
    • E. Sivan, E.A. Reece, Y.K. Wu, C.J. Homko, M. Polansky, M. Borenstein Dietary vitamin E prophylaxis and diabetic embryopathy Morphologic and biochemical analysis Am J Obstet.Gynecol 175 1996 793 799
    • (1996) Am J Obstet.Gynecol , vol.175 , pp. 793-799
    • Sivan, E.1    Reece, E.A.2    Wu, Y.K.3    Homko, C.J.4    Polansky, M.5    Borenstein, M.6
  • 145
    • 0344170888 scopus 로고
    • Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid
    • A.S. Goldman, L. Baker, R. Piddington, B. Marx, R. Herold, J. Egler Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid Proc Natl Acad Sci U S A 82 1985 8227 8231
    • (1985) Proc Natl Acad Sci U S a , vol.82 , pp. 8227-8231
    • Goldman, A.S.1    Baker, L.2    Piddington, R.3    Marx, B.4    Herold, R.5    Egler, J.6
  • 146
    • 0030022084 scopus 로고    scopus 로고
    • Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine
    • M. Sagara, J. Satoh, R. Wada Inhibition of development of peripheral neuropathy in streptozotocin-induced diabetic rats with N-acetylcysteine Diabetologia 39 1996 263 269
    • (1996) Diabetologia , vol.39 , pp. 263-269
    • Sagara, M.1    Satoh, J.2    Wada, R.3
  • 147
    • 0031023058 scopus 로고    scopus 로고
    • Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture
    • P. Wentzel, L. Thunberg, U.J. Eriksson Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture Diabetologia 40 1997 7 14
    • (1997) Diabetologia , vol.40 , pp. 7-14
    • Wentzel, P.1    Thunberg, L.2    Eriksson, U.J.3
  • 148
    • 0034892460 scopus 로고    scopus 로고
    • The role of folate in the prevention of neural tube defects: Human and animal studies
    • A. Fleming The role of folate in the prevention of neural tube defects Human and animal studies Nutr Rev 59 2001 S13 S20
    • (2001) Nutr Rev , vol.59
    • Fleming, A.1
  • 149
    • 12744254882 scopus 로고    scopus 로고
    • Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro
    • P. Wentzel, M. Gareskog, U.J. Eriksson Folic acid supplementation diminishes diabetes- and glucose-induced dysmorphogenesis in rat embryos in vivo and in vitro Diabetes 54 2005 546 553
    • (2005) Diabetes , vol.54 , pp. 546-553
    • Wentzel, P.1    Gareskog, M.2    Eriksson, U.J.3
  • 150
    • 0141448760 scopus 로고    scopus 로고
    • Development of early-onset type 2 diabetes in the young: Implications for child bearing
    • C.J. Homko, E.A. Reece Development of early-onset type 2 diabetes in the young implications for child bearing Curr Diab Rep 3 2003 313 318
    • (2003) Curr Diab Rep , vol.3 , pp. 313-318
    • Homko, C.J.1    Reece, E.A.2


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