Diacylglycerol production and protein kinase C activity are increased in a mouse model of diabetic embryopathy

Diabetes

Volumn 51, Issue 9, 2002, Pages 2804-2810

  Hiramatsu, Yuji ^a,c   Sekiguchi, Naotaka ^a,b   Hayashi, Michio ^a,b   Isshiki, Keiji ^a,b   Yokota, Tamotsu ^a,b   King, George L ^a,b   Loeken, Mary R ^a,b  

^a JOSLIN DIABETES CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; GLUCOSE; PROTEIN KINASE C; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENITAL DISORDER; CONTROLLED STUDY; DECIDUA; DIABETES MELLITUS; DIABETIC ANGIOPATHY; EMBRYO; EMBRYOPATHY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HYPERGLYCEMIA; IMMUNOBLOTTING; MOUSE; NEURAL TUBE; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

EID: 0036724696     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.9.2804     Document Type: Article

References (49)

1. Diabetes
2. Pregnancy outcomes in the Diabetes Control and Complications Trial
3. Malformations in infants of diabetic mothers occur before the seventh gestational week: Implications for treatment
4. Elevated maternal hemoglobin Alc in early pregnancy and major congenital anomalies in infants of diabetic mothers
5. Major malformations in infants of IDDM women: Vasculopathy and early first-trimester poor glycemic control
6. Diabetes mellitus during pregnancy and the risks for the specific birth defects: A population-based case-control study
7. Prospective population based survey of outcome of pregnancy in diabetic women: Results of the Northern Diabetic Pregnancy Audit, 1994
8. Teratogenic effects of excess glucose on head-fold rat embryos in culture
9. Effects of maternal diabetes on early embryogenesis: Alterations in morphogenesis produced by the ketone body, B-hydroxybutyrate
10. Biochemical basis for D,L,-beta-hydroxybutyrate-induced teratogenesis
11. The role of free radicals and membrane lipids in diabetes-induced congenital malformations
12. 2 levels in rat embryos exposed to a diabetic environment
13. Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos
14. Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats
15. Dietary vitanun E prophylaxis and diabetic embryopathy: Morphologic and biochemical analysis
16. Teratogenic effects of diabetes mellitus in the rat. Prevention by vitamin E
17. Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro
18. Neural tube defects in embryos of diabetic mice: Role of the Pax-3 gene and apoptosis
19. Hyperglycemia is responsible for altered gene expression, apoptosis, and neural tube defects associated with diabetic pregnancy
20. Timed interruption of insulin therapy in diabetic BB/E rat pregnancy: Effect on maternal metabolism and fetal outcome
21. Protein kinase C
22. Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes
23. Effects of the diacylglycerol complexing agent, cremophor, on nerve-conduction velocity and perfusion in diabetic rats
24. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus
25. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
26. High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells
27. Characterization of the mechanism for the chronic activation of diacylglycerolprotein kinase C pathway in diabetes and hypergalactosemia
28. Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels
29. Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation
30. The role of protein kinase C in the regulation of cell growth and in signalling to the cell nucleus
31. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor
32. Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells
33. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
34. Identification of two subtypes of protein kinase C in human placenta
35. Isolation of protein kinase C isoforms from human full-tenn placenta
36. Effects of diacylglycerol and gonadotropin-releasing hormone on human chorionic gonadotropin release by cultured trophoblast cells
37. Protein kinase C dependent and independent mechanisms controlling rat trophoblast cell DNA synthesis and differentiation
38. Downregulation of protein kinase C by phorbol ester increases expression of epidermal growth factor receptors in transformed trophoblasts and amplifies human chorionic gonadotropin production
39. Differential expression of protein kinase C isoforms in the human placenta
40. Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats
41. Changes in cardiac protein kinase C activities and isozymes in streptozotocin-induced diabetes
42. Altered expression and subcellular localization of diacylglycerol-sensitive protein kinase C isoforms in diabetic rat glomerular cells
43. Dysmorphogenic effects of a specific protein kinase C inhibitor during neurulation
44. Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity
45. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues
46. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
47. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway
48. Prevention of glomerular dysfunctions in diabetic rats by treatment of d-a-tocopherol