Abnormal skeletogenesis occurs coincident with increased apoptosis in the Splotch (Sp(2H)) mutant: Putative roles for Pax3 and PDGFRα in rib patterning

Anatomical Record

Volumn 255, Issue 3, 1999, Pages 353-361

  Dickman, Eileen D ^a   Rogers, Rhonda ^a   Conway, Simon J ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Apoptosis; Embryogenesis; Mouse; Patch; Pax3; PDGFR ; Rib fusion; Splotch

Indexed keywords

PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; IN SITU HYBRIDIZATION; MALE; MOUSE; MYOTOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIB; RIB MALFORMATION; SOMITE; THORAX;

ANIMALS; APOPTOSIS; DNA-BINDING PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCLE, SKELETAL; MUTATION; PAIRED BOX TRANSCRIPTION FACTORS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RIBS; SOMITES; THORAX; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0033168934     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0185(19990701)255:3<353::AID-AR11>3.0.CO;2-H     Document Type: Article

References (30)

1. Bernasconi M, Remppis A, Fredericks WJ, Rauscher III FJ, Schafer BW. 1996. Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of Pax proteins. PNAS 93:13164-13169.
2. Bober E, Frantz T, Arnold H-H, Grass P, Tremblay P. 1994. Pax3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development 120:603-612.
3. Braun T, Rudnick MA, Arnold H, Jaenisch R. 1992. Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death. Cell 71:369-382.
4. Burgess R, Rawls A, Brown D, Bradley A, Olson EN. 1996. Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature 384:570-573.
5. Conlon RA, Reaume AG, Rossant J. 1995. Notch1 is required for the coordinate segmentation of somites. Development 121:1533-1545.
6. 2H) mutant. Development 124:505-514.
7. Conway SJ, Henderson DJ, Kirby ML, Anderson RH, Copp AJ. 1997b. Development of a lethal congenital heart defect in the splotch (Pax3) mutant mouse. Cardiovascular Res 36:163-173.
8. Franz T, Kothary R, Surani MAH, Halata Z, Grim M. 1993. The Splotch mutation interferes with muscle development in the limbs. Anat Embryol 187:153-160.
9. Goulding M, Lumsden A, Paquette AJ. 1994. Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development 120:957-971.
10. Henderson DJ, Ybot-Gonzales P, Copp AJ. 1997. Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (Splotch). Mech Dev 69:39-51.
11. Jostes B, Walther C, Gruss P. 1990. The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev 33:27-37.
12. Kato N, Aoyama H. 1998. Dermomyotomal origin of the ribs as revealed by extirpation and transplantation experiments in chick and quail embryos. Development 125:3437-3443.
13. Kimata K, Oike Y, Tani K, Shinomura T, Yamagata M, Uritani M, Suzuki S. 1986. A large chondroitin sulfate proteoglycan (PG-M) synthesized before chondrogenesis in the limb bud of chick embryo. J Biol Chem 261:13517-13525.
14. LeMouellic H, Lallemand Y, Braulet P. 1992. Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Cell 69:251-264.
15. Mansouri A, Stoykova A, Torres M, Gruss P. 1996. Dysgenesis of cephalic neural crest derivatives in Pax7 - / - mutant mice. Development 122:831-838.
16. Orr-Urtreger A, Lonai P. 1992. Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo. Development 115:1045-1058.
17. Patapoutian A, Yoon JK, Miner JH, Wang S, Stark K, Wold B. 1995. Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. Development 121:3347-3358.
18. Phelan SA, Ito M, Loeken MR. 1997. Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis. Diabetes 46:1189-1197.
19. Rivera-Perez JA, Mallo M, Gendron-Maguire M, Gridley T, Behringer RB. 1995. goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. Development 121:3005-3012.
20. Sanders EJ. 1997. Cell death in the avian sclerotome. Dev Biol 192:551-563.
21. Shinomura T, Jensen KL, Yamagata M, Kimata K, Solursh M. 1990. The distribution of mesenchyme proteoglycan (PG-M) during wing bud outgrowth. Anat Embryol 181:227-233.
22. Soriano P. 1997. The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites. Development 124:2691-2700.
23. Tajbakhsh S, Rocancourt D, Buckingham M. 1996. Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 mice. Nature 384:266-269.
24. Takagi T, Moribe H, Kondoh H, Higashi Y. 1998. δEF1, a zinc finger and homeodomain transcription factor, is required for skeleton pattering in multiple lineages. Development 125:21-31.
25. Tremblay P, Dietrich S, Mericskay M, Schubert FR, Li Z, Paulin D. 1998. A crucial role for Pax3 in the development of the hypaxial musculature and long-range migration of muscle precursors. Dev Biol 203:49-61.
26. Wehrle-Haller B, Morrison-Graham K, Weston JA. 1996. Ectopic c-kit expression affects the fate of melanocyte precursors in Patch mutant embryos. Dev Biol 177:463-474.
27. Williams BA, Ordahl CP. 1994. Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification. Development 120:785-796.
28. Winnier GE, Hargett L, Hogan BL. 1997. The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev 11:926-940.
29. Woodcock-Mitchell J, Mitchell JJ, Low RB, Kieny M, Sengel P, Rubbia L, Skalli O, Jackson B, Gabbiani G. 1988. α-Smooth muscle actin is transiently expressed in embryonic rat cardiac and skeletal muscles. Differentiation 39:161-166.
30. Zhang W, Behringer RR, Olson EN. 1995. Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib abnormalities. Genes Dev 9:1388-1399.