Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment

Diabetes

Volumn 48, Issue 4, 1999, Pages 813-820

  Wentzel, Parri ^a   Welsh, Nils ^a   Eriksson, Ulf J ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; ISOPROSTANE; OXYGEN RADICAL; PROSTAGLANDIN E2;

ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; CROWN RUMP LENGTH; DIABETES MELLITUS; DOWN REGULATION; EMBRYO DEVELOPMENT; EMBRYOPATHY; ENZYME ACTIVITY; ENZYME INACTIVATION; FEMALE; GENE EXPRESSION; HYPERGLYCEMIA; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SOMITE; TERATOLOGY;

EID: 0032999922     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.4.813     Document Type: Article

References (57)

1. Mølsted-Pedersen L, Tygstrups I, Pedersen J: Congenital malformations in newborn infants of diabetic women: correlation with maternal diabetic vascular complications. Lancet i:1124-1126, 1964
2. Casson IF, Clarke CA, Howard CV, McKendrick O, Pennycook S, Pharoah PO, Platt MJ, Stanisstreet M, van Velszen D, Walkinshaw S: Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study. BMJ 315:275-278, 1997
3. Eriksson UJ, Borg LAH, Forsberg H, Simán CM, Suzuki N, Yang X: Can fetal loss be prevented? The biochemical basis of diabetic embryopathy. Diabetes Rev 4:49-69, 1996
4. Eriksson UJ, Borg LAH: Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro. Diabetologia 34:325-331, 1991
5. Eriksson UJ, Borg LAH: Diabetes and embryonic malformations. Role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos. Diabetes 42:411-419, 1993
6. Wentzel P, Thunberg L, Eriksson UJ: Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture. Diabetologia 40:7-14, 1997
7. Wentzel P, Eriksson UJ: Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro. Diabetes 47:677-684, 1998
8. Yang X, Borg LAH, Simán CM, Eriksson UJ: Maternal antioxidant treatments prevent diabetes-induced alterations of mitochondrial morphology in rat embryos. Anat Rec 251:303-315, 1998
9. Eriksson UJ, Simán CM: Pregnant diabetic rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in the offspring. Diabetes 45:1497-1502, 1996
10. Viana M, Herrera E, Bonet B: Teratogenic effects of diabetes mellitus in the rat. Prevention with vitamin E. Diabetologia 39:1041-1046, 1996
11. Sivan E, Reece EA, Wu YK, Homko CJ, Polansky M, Borenstein M: Dietary vitamin E prophylaxis and diabetic embryopathy: morphologic and biochemical analysis. Am J Obstet Gynecol 175:793-799, 1996
12. Simán CM, Eriksson UJ: Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats. Diabetes 46:1054-1061, 1997
13. Simán CM, Eriksson UJ: Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats. Diabetologia 40:1416-1424, 1997
14. Trocino RA, Akazawa S, Ishibashi M, Matsumoto K, Matsuo H, Yamamoto H, Goto S, Urata Y, Kondo T, Nagataki S: Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture. Diabetes 44:992-998, 1995
15. Forsberg H, Eriksson UJ, Melefors Ö, Welsh N: Beta-hydroxybutyrate increases reactive oxygen species in late but not in early postimplantation embryonic cells in vitro. Diabetes 47:255-262, 1997
16. Yang X, Borg LAH, Eriksson UJ: Altered metabolism and superoxide generation in neural tissue of rat embryos exposed to high glucose. Am J Physiol 272:E173-E180, 1997
17. Forsberg H, Eriksson UJ, Welsh N: Apoptosis in embryos of diabetic rats. Pharmacol Toxicol 83:104-111, 1998
18. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci U S A 87:9383-9387, 1990
19. 2,-isoprostanes) are formed in situ on phospholipids. Proc Natl Acad Sci U S A 89:10721-10725, 1992
20. 2-isoprostanes) in carbon tetrachloride hepatotoxicity: an animal model of lipid peroxidation. J Clin Invest 90:2502-2507, 1992
21. Nanji AA, Samsuddin K, Tahan SR, Sadrzadeh SMJ: Plasma levels of a novel non-cyclooxygenase-derived prostanoid (8-isoprostane) correlate with severity of liver injury in experimental alcoholic disease. J Pharmacol Exp Ther 269:1280-1285, 1994
22. 2 isoprostanes) in smokers. N Engl J Med 332:1198-1203, 1995
23. 2alfa levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Lett 368:225-229, 1995
24. Goldman AS, Baker L, Piddington R, Marx B, Herold R, Egler J: Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid. Proc Natl Acad Sci U S A 82:8227-8231, 1985
25. Pinter E, Reece EA, Leranth CZ, Garcia-Segura M, Hobbins JC, Mahoney MJ: Arachidonic acid prevents hyperglycemia-associated yolk sac damage and embryopathy. Am J Obstet Gynecol 155:691-702, 1986
26. Baker L, Piddington R, Goldman A, Egler J, Moehring J: Myo-inositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos. Diabetologia 33:593-596, 1990
27. 2 prevents anomalies induced by hyperglycemia or diabetic serum in mouse embryos. Diabetes 41:1644-1650, 1992
28. 2 levels in mouse embryos during neurulation. Diabetologia 39:915-920, 1996
29. De Witt D: Prostaglandin endoperoxidase synthase. Regulation of enzyme expression. Biochim Biophys Acta 1083:121-134, 1991
30. Moncada S, Gryglewski R, Bunting S, Vane JR: An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663-668, 1976
31. Whittle BJR, Higgs GA, Eakins KE, Moncada S, Vane JR: Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature 284:271-273, 1980
32. O'Banion MK, Sadowski HB, Winn V, Young DA: A serum- and glucocorticoid-regulated 4-kilobase mRNA from Swiss 3T3 cells, encodes a cyclooxygenase-related protein. J Biol Chem 266:23261-23267, 1991
33. Sirois J, Richards JS: Purification and characterisation of a novel, distinct isoform of prostaglandin endoperoxidase synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. J Biol Chem 267:6382-6388, 1992
34. Sirois J, Richards JS: Transcription regulation of the rat prostaglandin endoperoxidase synthase 2 gene in granulosa cells: evidence for the role of a cis-acting C/EBPbeta promoter element. J Biol Chem 268:21931-21938, 1993
35. 2. Arthritis Rheumatoid 37:653-661, 1994
36. Crofford LJ, Wilder RL, Ristimaki AP, Remmers EF, Epps HR, Hla T: Cyclooxygenase 1 and 2 expression in rheumatoid synovial tissue: effects of interleukin 1-beta, phorbol ester, and corticosteroids. J Clin Invest 93:1095-1101, 1994
37. Diaz A, Chepenik KP, Korn JH, Reginato AM, Jimenez SA: Differential regulation of cyclooxygenases 1 and 2 by interleukin-1 beta, tumor necrosis factor-alpha, and transforming growth factor-beta 1 in human lung fibroblasts. Exp Cell Res 241:222-229, 1998
38. Lee HS, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D, Hwang D: Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267:25934-25938, 1992
39. Reddy ST, Herschman HR: Ligand-induced prostaglandin synthesis requires expression of the TIS 10-PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J Biol Chem 269:15473-15480, 1994
40. New DAT: Whole embryo culture and the study of mammalian embryos during embryogenesis. Biol Rev 53:81-122, 1978
41. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951
42. Winer BJ: Statistical Principles in Experimental Design. New York, McGraw-Hill, 1971
43. Ostle B: Statistics in Research. 2nd ed. Ames, IA, Iowa State University, 1963
44. 2 in diabetic pregnancy: further clues to the etiology of diabetic embryopathy. Prostaglandins 50:121-126, 1995
45. Onoe Y, Miyaura C, Kaminakayashiki T, Nagai Y, Noguchi K, Chen QR, Seo H, Ohta H, Nozawa S, Kudo I, Suda T: IL-13 and 1L-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts. J Immunol 156:758-764, 1996
46. Palmer AM, Thomas CR, Gopaul N, Dhir S, Änggård EE, Poston L, Tribe RM: Dietary antioxidant supplementation reduces lipid peroxidation but impairs vascular function in small mesenteric arteries of the streptozotocin-diabetic rat. Diabetologia 41:148-156, 1998
47. Sano T, Umeda F, Hashimoto T, Nawata H, Utsumi H: Oxidative stress measurements by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes. Diabetologia 41:1355-1360, 1998
48. Yang X, Borg LAH, Eriksson UJ: Altered mitochondrial morphology of rat embryos in diabetic pregnancy. Anat Rec 241:255-267, 1995
49. Buckley BJ, Kent RS, Whorton AR: Regulation of endothelial cell prostaglandin synthesis by glutathione. J Biol Chem 266:16659-16666, 1991
50. 2 synthesis after oxidant stress is dependent on cell glutathione content. Am J Physiol 266:C1392-C1399, 1994
51. Engström E, Haglund A, Eriksson UJ: Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos. Pediatr Res 30:150-153, 1991
52. Pinter E, Reece EA, Ogburn PJ, Turner S, Hobbins JC, Mahoney MJ. Naftolin F: Fatty acid content of yolk sac and embryo in hyperglycemia-induced embryopathy and effect of arachidonic acid supplementation. Am J Obstet Gynecol 159:1484-1490, 1988
53. Hod M, Star S, Passonneau JV, Unterman TG, Freinkel N: Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis. Biochem Biophys Res Comm 140:974-980, 1986
54. Akashi M, Akazawa S, Akazawa M, Trocino R, Hashimoto M, Maeda Y, Yamamoto H, Kawasaki E, Takino H, Yokota A, Nagataki S: Effects of insulin and myo-inositol on embryo growth and development during early organogenesis in streptozocin-induced diabetic rats. Diabetes 40:1574-1579, 1991
55. Eriksson UJ, Wentzel P, Minhas HS, Thornalley PJ: Teratogenicity of 3-deoxyglucosone and diabetic embryopathy. Diabetes 47:1960-1966, 1998
56. Lee AT, Reis D, Eriksson UJ: Hyperglycemia induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo. Diabetes 48:371-376, 1999
57. Phelan SA, Ito M, Loeken MR: Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis. Diabetes 46:1189-1197, 1997