Microspheres for protein delivery prepared from amphiphilic multiblock copolymers 2. Modulation of release rate

Journal of Controlled Release

Volumn 67, Issue 2-3, 2000, Pages 249-260

  Bezemer, J M ^a   Radersma, R ^a   Grijpma, D W ^a   Dijkstra, P J ^a   Van Blitterswijk, C A ^a,b   Feijen, J ^a  

^a Poly Chem Biomaterials   (Netherlands)

^b IsoTis BV   (Netherlands)

Author keywords

Block copolymer; Controlled release; Microsphere; Protein; Swelling

Indexed keywords

COPOLYMER; LYSOZYME; MACROGOL; MICROSPHERE; POLYBUTYLENE TEREPHTHALATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG RELEASE; KINETICS; MOLECULAR WEIGHT; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

ALGORITHMS; DIFFUSION; DRUG COMPOUNDING; EMULSIONS; FLUORESCEIN-5-ISOTHIOCYANATE; KINETICS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MOLECULAR WEIGHT; MURAMIDASE; PARTICLE SIZE; POLYESTERS; POLYETHYLENE TEREPHTHALATES; POLYMERS; PROTEINS; SOLVENTS; VEHICLES;

EID: 0034601241     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00212-1     Document Type: Article

References (48)

1. Schwendeman S.P., Costantino H.R., Gupta R.K., Langer R. Peptide, protein, and vaccine delivery from implantable polymeric systems: progress and challenges. Park K. Controlled Drug Delivery, Challenges and Strategies. 1996;229-267 Am. Chem. Soc, Washington, DC.
2. Harland R.S., Peppas N.A. Hydrophilic/hydrophobic, block and graft copolymeric hydrogels: synthesis, characterization, and solute partition and penetration. J. Control. Release. 26:1993;157-174.
3. Bezemer J.M., Grijpma D.W., Dijkstra P.J., van Blitterswijk C.A., Feijen J. A controlled release system for proteins based on poly(ether ester) block-copolymers: polymer network characterization. J. Control. Release. 62:1999;393-405.
4. Liu H.-J., Hsieh C.-T., Hu D.S.-G. Solute diffusion through degradable semicrystalline polyethylene glycol/poly(L-lactide) copolymers. Polym. Bull. 32:1994;463-470.
5. Zhu K.J., Xiangzhou L., Shilin Y. Preparation, characterization and properties of polylactide (PLA)-poly(ethylene glycol) (PEG) copolymers: a potential drug carrier. J. Appl. Polym. Sci. 39:1990;1-9.
6. Penco M., Marcioni S., Ferruti P., D'Antone S., Deghenghi R. Degradation behaviour of block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments. Biomaterials. 17:1996;1583-1590.
7. Bezemer J.M., Radersma R., Grijpma D.W., Dijkstra P.J., Feijen J., van Blitterswijk C.A. Zero-order release of lysozyme from poly(ethylene glycol)/poly(butylene terephthalate) matrices. J. Controlled Release. 64:2000;179-192.
8. Harris J.M. Introduction to biotechnical and biomedical applications of poly(ethylene glycol). Harris J.M. Poly(ethylene glycol) Chemistry, Biotechnical and Biomedical Applications. 1992;1-12 Plenum, New York.
9. Cohn D., Younes H. Biodegradable PEO/PLA block copolymers. J. Biomed. Mater. Res. 22:1988;993-1009.
10. D.J. Casey, P.K. Jarret, L. Rosati, US Patent 4,716,203 (1987).
11. Li Y.-X., Kissel T. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(L-lactic acid), or poly(L-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks. J. Control. Release. 27:1993;247-257.
12. Cerrai P., Tricoli M., Andruzzi F., Paci M., Paci M. Polyether-polyester block copolymers by non-catalysed polymerization of ε-caprolactone with poly(ethylene glycol). Polymer. 30:1989;338-343.
13. Gilding D.K., Reed A.M. Biodegradable polymers for use in surgery - poly(ethylene oxide) poly(ethylene terephthalate) (PEO/PET) copolymers: 1. Polymer. 20:1979;1454-1458.
14. Bouillot P., Petit A., Dellacherie E. Protein encapsulation in biodegradable amphiphilic microspheres. 1. Polymer synthesis and characterization and microsphere elaboration. J. Appl. Polym. Sci. 68:1998;1695-1702.
15. Youxin L., Volland C., Kissel T. In-vitro degradation and bovine serum albumin release of the ABA triblock copolymers consisting of poly(L(+)lactic acid-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks. J. Control. Release. 32:1994;121-128.
16. Li X., Xiao J., Deng X., Li X., Wang H., Jia W., Zhang W., Men L., Yangm Y., Zheng Z. Preparation of biodegradable polymer microspheres encapsulating protein with micron sizes. J. Appl. Polym. Sci. 66:1997;583-590.
17. Li X., Deng X., Yuan M., Xiong C., Huang Z., Zhang Y., Jia W. Investigation on process parameters involved in preparation of poly-DL-lactide-poly(ethylene glycol) microspheres containing Leptospira interrogans antigens. Int. J. Pharm. 178:1999;245-255.
18. Kissel T., Li Y.X., Volland C., Görich S., Koneberg R. Parenteral protein delivery systems using biodegradable polyester of ABA block structure, containing hydrophobic pol(lactide-co-glycolide) A blocks and hydrophilic poly(ethylene oxide) B blocks. J. Control. Release. 39:1996;315-326.
19. Morlock M., Kissel T., Li Y.X., Koll H., Winter G. Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties. J. Control. Release. 56:1998;105-115.
20. Mader K., Bittner B., Li Y., Wohlauf W., Kissel T. Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly(lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethyleneoxide) B blocks. Pharm. Res. 15:1998;787-793.
21. Shah S.S., Cha Y., Pitt C.G. Poly(glycolic acid-co-DL-lactic acid): diffusion or degradation controlled drug delivery? J. Control. Release. 18:1992;261-270.
22. Couvreur P., Puisieux F. Nano- and microparticles for the delivery of polypeptides and proteins. Adv. Drug Delivery Rev. 10:1993;141-162.
23. Lu W., Park T.G. Protein release from poly(lactic-co-glycolic acid) microspheres: protein stability problems. J. Pharm. Sci. Technol. 49:1995;13-19.
24. Lu W., Park T.G. In vitro release profiles of eristostatin from biodegradable polymeric microspheres: protein aggregation problems. Biotechnol. Prog. 11:1995;224-227.
25. Uchida T., Yagi A., Oda Y., Nakada Y., Goto S. Instability of bovine insulin in poly(lactide-co-glycolide) (PLGA) microspheres. Chem. Pharm. Bull. 44:1996;235-236.
26. Crotts G., Sah H., Park T.G. Adsorption determines in-vitro protein release rate from biodegradable microspheres: quantitative analysis of surface area during degradation. J. Control. Release. 47:1997;101-111.
27. Crotts G., Park T.G. Stability and release of bovine serum albumin encapsulated within poly(lactide-co-glycolide) microparticles. J. Control. Release. 44:1997;123-134.
28. Park T.G., Lee H.Y., Nam Y.S. A new preparation method for protein laoded poly(DL-lactic-co-glycolic acid) microspheres and protein release mechanism study. J. Control. Release. 55:1998;181-191.
29. Bittner B., Morlock M., Koll H., Winter G., Kissel T. Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics. Eur. J. Pharm. Biopharm. 45:1998;295-305.
30. Li S., Garreau, Vert M., Petrova T., Manolova N., Rashkov I. Hydrolytic degradation of poly(oxyethylene)-poly-(ε-caprolactone) multiblock copolymers. J. Appl. Polym. Sci. 68:1998;989-998.
31. Reed A.M., Gilding D.K. Biodegradable polymers for use in surgery - poly(ethylene oxide) poly(ethylene terephthalate) (PEO/PET) copolymers: 2. In vitro degradation. Polymer. 22:1981;499-504.
32. Bakker D., van Blitterswijk C.A., Hesseling S.C., Koerten H.K., Kuijpers W., Grote J.J. Biocompatibility of a polyether urethane, polypropylene oxide, and a polyether polyester copolymer. A qualitative and quantitative study of three alloplastic tympanic membrane materials in the rat middle ear. J. Biomed. Mater. Res. 24:1990;489-515.
33. Grote J.J., Bakker D., Hesseling S.C., van Blitterswijk C.A. New alloplastic tympanic membrane material. Am. J. Otol. 12:1991;329-335.
34. J.A. van Loon, Thesis, University of Leiden, Leiden, The Netherlands, 1995.
35. Beumer G.J., van Blitterswijk C.A., Bakker D., Ponec M. Cell-seeding and in vitro biocompatibility evaluation of polymeric matrices of PEO/PBT copolymers and PLLA. Biomaterials. 14:1993;598-604.
36. Beumer G.J., van Blitterswijk C.A., Ponec M. Biocompatibility of degradable matrix induced as a skin substitute: an in vivo evaluation. J. Biomed. Mater. Res. 28:1994;545-552.
37. Bakkum E.A., Trimbos J.B., Dalmeijer R.A.J., van Blitterswijk C.A. Preventing postoperative intraperitoneal adhesion formation with Polyactive, a degradable copolymer acting as a barrier. J. Mater. Sci.: Mater. Med. 6:1995;41-45.
38. Radder A.M., Leenders H., van Blitterswijk C.A. Interface reactions to PEO/PBT copolymers: (Polyactive): a study on bone-bonding. J. Biomed. Mater. Res. 28:1994;141-151.
39. Radder A.M., Leenders H., van Blitterswijk C.A. Application of PEO/PBT copolymers for bone replacement. J. Biomed. Mater. Res. 30:1996;341-351.
40. J.M. Bezemer, R. Radersma, D.W. Grijpma, P.J. Dijkstra, J. Feijen, C.A. van Blitterswijk, Microspheres for protein delivery from amphiphilic multiblock copolymers. 1. Influence of preparation techniques on particle characteristics and protein delivery, J. Control. Release (2000) accepted.
41. Crank J. The Mathematics of Diffusion. 2nd Edition :1975;Oxford University Press, New York.
42. Baker R.W., Lonsdale H.K. Controlled release: Mechanisms and rates. Tanquarry A.C., Lacey R.E. Controlled Release of Biologically Active Agents. 1974;15-71 Plenum, New York.
43. Uchida T., Goto S., Foster T.P. Particle size studies for subcutaneous delivery of poly(lactic-co-glycolide) microspheres containing ovalbumin as vaccine formulation. J. Pharm. Pharmacol. 47:1994;556-560.
44. Jalil R., Nixon J.R. Microencapsulation using poly(L-lactic acid) II: Preparative variables affecting microcapsule properties. J. Microencapsulation. 7:1990;25-39.
45. Jeyanthi R., Metha R.C., Thanoo B.C., DeLuca P.P. Effect of processing parameters on the properties of peptide-containing PLGA microspheres. J. Microencapsulation. 14:1997;103-174.
46. Schlicher E.J.A.M., Postma N.S., Zuidema J., Talsma H., Hennink W.E. Preparation and characterisation of poly(D,L-lactic-co-glycolic acid) microspheres containing desferrioxamine. Int. J. Pharm. 153:1997;235-245.
47. McGee J.P., Singh M., Li X.-M., Qiu H., O'Hagan D.T. The encapsulation of a model protein in poly(D,L-lactide-co-glycolide) microparticles of various sizes: an evaluation of process reproducibility. J. Microencapsulation. 14:1997;197-210.
48. Maa Y.-F., Hsu C.C. Effect of primary emulsions on microsphere size and protein-loading in the double emulsion process. J. Microencapsulation. 13:1996;225-241.