6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for specific inhibitors of human leukocyte elastase

Journal of Medicinal Chemistry

Volumn 42, Issue 20, 1999, Pages 4161-4171

  Doucet, Caroline ^a   Pochet, Lionel ^b,c   Thierry, Nicole ^a   Pirotte, Bernard ^b   Delarge, Jacques ^b   Rebound Ravaux, Michèle ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLOROPYRID 3 YL 6 ACETOXYMETHYL 2 OXO 2H 1 BENZOPYRAN 3 CARBOXYLIC ACID; 6 CHLOROPYRID 2 YL 6 CHLOROMETHYL 2 OXO 2H 1 BENZOPYRAN 3 CARBOXYLIC ACID; CHYMOTRYPSIN A; ENZYME INHIBITOR; LEUKOCYTE ELASTASE; THROMBIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFICACY; DRUG INHIBITION; DRUG STRUCTURE; ENZYME INACTIVATION; ENZYME INHIBITION; ESTERIFICATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; ENZYME INHIBITORS; HUMANS; KINETICS; LEUKOCYTE ELASTASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033533761     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990070k     Document Type: Article

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