Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of α-chymotrypsin: Significance of the "aromatic" nature of the novel ester-type coumarin for strong inhibitory activity

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2579-2585

  Pochet, Lionel ^a   Doucet, Caroline ^b   Schynts, Marc ^a   Thierry, Nicole ^b   Boggetto, Nicole ^b   Pirotte, Bernard ^a   Jiang, Kai Y ^b   Masereel, Bernard ^a   De Tullio, Pascal ^a   Delarge, Jacques ^a   Reboud Ravaux, Michèle ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 (CHLOROMETHYL) 2 OXO 2H 1 BENZOPYRAN 3 CARBOXYLIC ACID; AMIDE; BENZOPYRAN DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHYMOTRYPSIN; CHYMOTRYPSIN INHIBITOR; ESTER DERIVATIVE; LEUKOCYTE ELASTASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; NONHUMAN;

ANIMALS; BENZOPYRANS; CATTLE; CHYMOTRYPSIN; HUMANS; KINETICS; LEUKOCYTE ELASTASE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PANCREATIC ELASTASE; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030014368     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960090b     Document Type: Article

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