Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry

Tetrahedron

Volumn 59, Issue 25, 2003, Pages 4557-4561

  Pochet, Lionel ^a   Dieu, Marc ^a   Frédérick, Raphaël ^a   Murray, Ann Marie ^a   Kempen, Isabelle ^b   Pirotte, Bernard ^b   Masereel, Bernard ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Acylenzyme; Alkylenzyme; Chymotrypsin; Coumarin; Enzyme inhibitor; Mass spectrometry; Mechanism; Serine protease

Indexed keywords

ACETIC ACID; CARBONYL DERIVATIVE; CHLORIDE; CHYMOTRYPSIN; COUMARIN DERIVATIVE; LACTONE; SERINE;

ALKYLATION; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 0038173450     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(03)00660-4     Document Type: Article

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