Structure-based design and synthesis of novel thrombin inhibitors based on phosphinic peptide mimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 1957-1962

  Li, Min ^a,b   Lin, Zhaolan ^a   Johnson, Michael E ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; THROMBIN INHIBITOR;

ARTICLE; BLOOD CLOTTING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN DEGRADATION;

ANTITHROMBINS; BINDING SITES; COMPUTER SIMULATION; DIPEPTIDES; DRUG DESIGN; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; PHOSPHINIC ACIDS; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 0033584174     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00319-4     Document Type: Article

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