FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury

Experimental Neurology

Volumn 196, Issue 2, 2005, Pages 390-400

  Casha, S ^b   Yu, W R ^b   Fehlings, M G ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b NONE

Author keywords

Apoptosis; FAS; Neuroprotection; Oligodendrocyte; Spinal cord injury

Indexed keywords

FAS ANTIGEN; MYELIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN FUNCTION; CELL DEATH; CELL SURVIVAL; CLIP; CONTROLLED STUDY; FEMALE; LOCOMOTION; MOUSE; MOUSE MUTANT; NERVE CELL; NERVE FIBER; NERVOUS SYSTEM INJURY; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REACTION TIME; SIGNAL TRANSDUCTION; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; STATISTICAL SIGNIFICANCE; TISSUE CULTURE; WILD TYPE;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; AXONS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; CASPASES; CELL COUNT; DISEASE MODELS, ANIMAL; FEMALE; FUNCTIONAL LATERALITY; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT-SHOCK PROTEINS; IN SITU NICK-END LABELING; INDOLES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUSCLE PROTEINS; PHOSPHOPYRUVATE HYDRATASE; PROPIDIUM; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; STILBAMIDINES; TIME FACTORS;

EID: 27744542561     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.08.020     Document Type: Article

References (51)

1. Y. Abe, T. Yamamoto, Y. Sugiyama, T. Watanabe, N. Saito, H. Kayama, and T. Kumagai Apoptotic cells associated with Wallerian degeneration after experimental spinal cord injury: a possible mechanism of oligodendroglial death J. Neurotrauma 16 1999 945 952
2. D.M. Basso, M.S. Beattie, and J.C. Bresnahan A sensitive and reliable locomotor rating scale for open field testing in rats J. Neurotrauma 12 1995 1 21
3. C. Bjartmar, X. Yin, and B.D. Trapp Axonal pathology in myelin disorders J. Neurocytol. 28 1999 383 395
4. S. Casha, W.R. Yu, and M.G. Fehlings Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and P75 expression following spinal cord injury Neuroscience 103 2001 203 218
5. B.A. Citron, P.M. Arnold, C. Sebastian, F. Qin, S. Malladi, S. Ameenuddin, M.E. Landis, and B.W. Festoff Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death Exp. Neurol. 166 2000 213 226
6. R.S. Clark, P.M. Kochanek, S.C. Watkins, M. Chen, C.E. Dixon, N.A. Seidberg, J. Melick, J.E. Loeffert, P.D. Nathaniel, K.L. Jin, and S.H. Graham Caspase-3 mediated neuronal death after traumatic brain injury in rats J. Neurochem. 74 2000 740 753
7. M.J. Crowe, J.C. Bresnahan, S.L. Shuman, J.N. Masters, and M.S. Beattie Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys Nat. Med. 3 1997 73 76
8. D. Demjen, S. Klussmann, S. Kleber, C. Zuliani, B. Stieltjes, C. Metzger, U.A. Hirt, H. Walczak, W. Falk, M. Essig, L. Edler, P.H. Krammer, and A. Martin-Villalba Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury Nat. Med. 7 2004 7
9. E. Emery, P. Aldana, M.B. Bunge, W. Puckett, A. Srinivasan, R.W. Keane, J. Bethea, and A.D. Levi Apoptosis after traumatic human spinal cord injury J. Neurosurg. 89 1998 911 920
10. R.S. Ghirnikar, Y.L. Lee, and L.F. Eng Chemokine antagonist infusion promotes axonal sparing after spinal cord contusion injury in rat Neurosci. Res. 64 2001 582 589 (Jun 15)
11. F. Gillardon, I. Kiprianova, J. Sandkuhler, K.A. Hossmann, and M. Spranger Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia Neuroscience 93 1999 1219 1222
12. H. Hara, R.M. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimizu-Sasamata, J. Yuan, and M.A. Moskowitz Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage Proc. Natl. Acad. Sci. U. S. A. 94 1997 2007 2012
13. M. Joshi, and M.G. Fehlings Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology J. Neurotrauma 19 2002 175 190
14. M. Joshi, and M.G. Fehlings Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery J. Neurotrauma 19 2002 191 203
15. K. Katoh, T. Ikata, S. Katoh, Y. Hamada, K. Nakauchi, T. Sano, and M. Niwa Induction and its spread of apoptosis in rat spinal cord after mechanical trauma Neurosci. Lett. 216 1996 9 12
16. R.W. Keane, S. Kraydieh, G. Lotocki, J.R. Bethea, S. Krajewski, J.C. Reed, and W.D. Dietrich Apoptotic and anti-apoptotic mechanisms following spinal cord injury J. Neuropathol. Exp. Neurol. 60 2001 422 429
17. G.M. Kim, J. Xu, J. Xu, S.K. Song, P. Yan, G. Ku, X.M. Xu, and C.Y. Hsu Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury J. Neurosci. 21 2001 6617 6625
18. A.V. Krassioukov, A. Ackery, G. Schwartz, Y. Adamchik, Y. Liu, and M.G. Fehlings An in vitro model of neurotrauma in organotypic spinal cord cultures from adult mice Brain Res. Brain Res. Protoc. 10 2002 60 68
19. Y.B. Lee, T.Y. Yune, S.Y. Baik, Y.H. Shin, S. Du, H. Rhim, E.B. Lee, Y.C. Kim, M.L. Shin, G.J. Markelonis, and T.H. Oh Role of tumor necrosis factor-alpha in neuronal and glial apoptosis after spinal cord injury Exp. Neurol. 166 2000 190 195
20. G.L. Li, G. Brodin, M. Farooque, K. Funa, A. Holtz, W.L. Wang, and Y. Olsson Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord J. Neuropathol. Exp. Neurol. 55 1996 280 289
21. G.L. Li, M. Farooque, A. Holtz, and Y. Olsson Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord Acta Neuropathol. (Berl) 98 1999 473 480
22. G.L. Li, M. Farooque, and Y. Olsson Changes of Fas and Fas ligand immunoreactivity after compression trauma to rat spinal cord Acta Neuropathol. (Berl) 100 2000 75 81
23. X. Li, M. Oudega, H.A. Dancausse, and A.D. Levi The effect of methylprednisolone on caspase-3 activation after rat spinal cord transection Restor. Neurol. Neurosci. 17 2000 203 209
24. X.Z. Liu, X.M. Xu, R. Hu, C. Du, S.X. Zhang, J.W. McDonald, H.X. Dong, Y.J. Wu, G.S. Fan, M.F. Jacquin, C.Y. Hsu, and D.W. Choi Neuronal and glial apoptosis after traumatic spinal cord injury J. Neurosci. 17 1997 5395 5406
25. J. Lou, L.G. Lenke, F.J. Ludwig, and M.F. O'Brien Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury Spinal Cord 36 1998 683 690
26. K. Matsushita, Y. Wu, J. Qiu, L. Lang-Lazdunski, L. Hirt, C. Waeber, B.T. Hyman, J. Yuan, and M.A. Moskowitz Fas receptor and neuronal cell death after spinal cord ischemia J. Neurosci. 20 2000 6879 6887
27. Y. Morita-Fujimura, M. Fujimura, M. Kawase, K. Murakami, G.W. Kim, and P.H. Chan Inhibition of interleukin-1beta converting enzyme family proteases (caspases) reduces cold injury-induced brain trauma and DNA fragmentation in mice J. Cereb. Blood Flow Metab. 19 1999 634 642
28. S. Nakahara, K. Yone, T. Sakou, S. Wada, T. Nagamine, T. Niiyama, and H. Ichijo Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis J. Neuropathol. Exp. Neurol. 58 1999 442 450
29. S. Nakatsuru, M. Terada, M. Nishihara, J. Kamogawa, T. Miyazaki, W.M. Qu, K. Morimoto, C. Yazawa, H. Ogasawara, Y. Abe, K. Fukui, G. Ichien, M.R. Ito, S. Mori, Y. Nakamura, and M. Nose Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice Pathol. Int. 49 1999 974 982
30. S.K. Ray, D.C. Matzelle, G.G. Wilford, E.L. Hogan, and N.L. Banik E-64-d prevents both calpain upregulation and apoptosis in the lesion and penumbra following spinal cord injury in rats Brain Res. 867 2000 80 89
31. S.K. Ray, D.D. Matzelle, G.G. Wilford, E.L. Hogan, and N.L. Banik Increased calpain expression is associated with apoptosis in rat spinal cord injury: calpain inhibitor provides neuroprotection Neurochem. Res. 25 2000 1191 1198
32. N. Saito, T. Yamamoto, T. Watanabe, Y. Abe, and T. Kumagai Implications of p53 protein expression in experimental spinal cord injury J. Neurotrauma 17 2000 173 182
33. M. Sakurai, T. Hayashi, K. Abe, M. Sadahiro, and K. Tabayashi Delayed selective motor neuron death and fas antigen induction after spinal cord ischemia in rabbits Brain Res. 797 1998 23 28
34. M. Sakurai, T. Hayashi, K. Abe, Y. Itoyama, K. Tabayashi, and W.I. Rosenblum Cyclin D1 and Cdk4 protein induction in motor neurons after transient spinal cord ischemia in rabbits Stroke 31 2000 200 207 (Jan.)
35. K. Satake, Y. Matsuyama, M. Kamiya, H. Kawakami, H. Iwata, K. Adachi, and K. Kiuchi Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury Brain Res. Mol. Brain Res. 85 2000 114 122
36. M. Schmidt, N. Lugering, A. Lugering, H.G. Pauels, K. Schulze-Osthoff, W. Domschke, and T. Kucharzik Role of the CD95/CD95 ligand system in glucocorticoid-induced monocyte apoptosis J. Immunol. 166 2001 1344 1351
37. P.A. Schumacher, J.H. Eubanks, and M.G. Fehlings Increased calpain I-mediated proteolysis, and preferential loss of dephosphorylated NF200, following traumatic spinal cord injury Neuroscience 91 1999 733 744
38. P.A. Schumacher, R.G. Siman, and M.G. Fehlings Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury J. Neurochem. 74 2000 1646 1655
39. S.L. Shuman, J.C. Bresnahan, and M.S. Beattie Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats J. Neurosci. Res. 50 1997 798 808
40. R.M. Siegel, F.K. Chan, H.J. Chun, and M.J. Lenardo The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity Nat. Immunol. 1 2000 469 474
41. F. Silvestris, P. Cafforio, M. Tucci, A. Del Prete, and F. Dammacco VEINCTR-N, an immunogenic epitope of Fas (CD95/Apo-I), and soluble Fas enhance T-cell apoptosis in vitro. II. Functional analysis and possible implications in HIV-1 disease Mol. Med. 6 2000 509 526
42. J.E. Springer, R.D. Azbill, and P.E. Knapp Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury Nat. Med. 5 1999 943 946
43. G. Ugolini, C. Raoul, A. Ferri, C. Haenggeli, Y. Yamamoto, D. Salaun, C.E. Henderson, A.C. Kato, B. Pettmann, and A.O. Hueber Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo J. Neurosci. 23 2003 8526 8531
44. S. Vidal, D.H. Kono, and A.N. Theofilopoulos Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice J. Clin. Invest. 101 1998 696 702
45. S. Wada, K. Yone, Y. Ishidou, T. Nagamine, S. Nakahara, T. Niiyama, and T. Sakou Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-d-aspartate receptor antagonist J. Neurosurg. 91 1999 98 104
46. P. Warden, N.I. Bamber, H. Li, A. Esposito, K.A. Ahmad, C.Y. Hsu, and X.M. Xu Delayed glial cell death following wallerian degeneration in white matter tracts after spinal cord dorsal column cordotomy in adult rats Exp. Neurol. 168 2001 213 224
47. A.G. Yakovlev, S.M. Knoblach, L. Fan, G.B. Fox, R. Goodnight, and A.I. Faden Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury J. Neurosci. 17 1997 7415 7424
48. X. Yin, T.O. Crawford, J.W. Griffin, P. Tu, V.M. Lee, C. Li, J. Roder, and B.D. Trapp Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons J. Neurosci. 18 1998 1953 1962
49. C. Yong, P.M. Arnold, M.N. Zoubine, B.A. Citron, I. Watanabe, N.E. Berman, and B.W. Festoff Apoptosis in cellular compartments of rat spinal cord after severe contusion injury J. Neurotrauma 15 1998 459 472
50. O. Yoshino, H. Matsuno, H. Nakamura, K. Yudoh, Y. Abe, T. Sawai, M. Uzuki, S. Yonehara, and T. Kimura The role of Fas-mediated apoptosis after traumatic spinal cord injury Spine 29 2004 1394 1404
51. M. Zurita, J. Vaquero, and I. Zurita Presence and significance of CD-95 (Fas/APO1) expression after spinal cord injury J. Neurosurg. 94 2001 257 264